Results 31 to 40 of about 60,229 (263)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Polypyrimidine tract binding protein-1 (PTB1) is a determinant of the tissue and host tropism of a human rhinovirus/poliovirus chimera PV1(RIPO). [PDF]

PLoS ONE, 2013
The internal ribosomal entry site (IRES) of picornavirus genomes serves as the nucleation site of a highly structured ribonucleoprotein complex essential to the binding of the 40S ribosomal subunit and initiation of viral protein translation.
Nusrat Jahan, Eckard Wimmer, Steffen Mueller   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Violencias machistas y exclusión residencial: barreras a la intervención desde la experiencia profesional en Illes Balears

Cuadernos de Trabajo Social
La exclusión residencial en la experiencia de las mujeres ha sido una realidad invisibilizada donde se identifican mayores índices de violencia, a pesar de ello en la comunidad de Illes Balears no existen servicios específicos que atiendan a este perfil
Isabel Nadal-Amengual, Paloma Martín Martín, Clara Ferragut Moranta, Sara Bouza Bañobre   +3 more
doaj   +1 more source

Resurrection of a Viral Internal Ribosome Entry Site from a 700 Year Old Ancient Northwest Territories Cripavirus

Viruses, 2021
The dicistrovirus intergenic region internal ribosome entry site (IGR IRES) uses an unprecedented, streamlined mechanism whereby the IRES adopts a triple-pseudoknot (PK) structure to directly bind to the conserved core of the ribosome and drive ...
Xinying Wang, Marli Vlok, Stephane Flibotte, Eric Jan   +3 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Giardiavirus internal ribosome entry site has an apparently unique mechanism of initiating translation.

PLoS ONE, 2009
Giardiavirus (GLV) utilizes an internal ribosome entry site (IRES) for translation initiation in the early branching eukaryote Giardia lamblia. Unlike most of the viral IRESs among higher eukaryotes, which localize primarily within the 5'-untranslated ...
Srinivas Garlapati, Ching C Wang
doaj   +1 more source

Tutorial on Reasoning for IR & IR for Reasoning

Information retrieval has long focused on ranking documents by semantic relatedness. Yet many real-world information needs demand more: enforcement of logical constraints, multi-step inference, and synthesis of multiple pieces of evidence. Addressing these requirements is, at its core, a problem of reasoning.
Hoveyda, M., Eustratiadis, P., Vries, A.P. de, Rijke, M. de   +3 more
openaire   +3 more sources

Interdiffusion in the Ir-Rich Solid Solutions of Ir-Pt, Ir-Rh, and Ir-Re Binary Alloys [PDF]

Journal of Phase Equilibria and Diffusion, 2011
Interdiffusivity in the Ir-rich solid solutions of Ir-X (X = Pt, Rh and Re) binary alloys was investigated in the temperature range of 2073-2373 K. The interdiffusion coefficients within the solute concentration range up to 10 at.% were evaluated through conventional diffusion-couple experiments.
Sekido, Nobuaki, Hoshino, Akinori, Fukuzaki, Masahiro, Maruko, Tomohiro, Yamabe-Mitarai, Yoko   +4 more
openaire   +1 more source