Results 31 to 40 of about 78,348 (310)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Is the “IR Coincidence” Just That?

open access: yesThe Astrophysical Journal, 2005
Previous work by Motch et al. suggested that in the low/hard state of GX 339-4 the soft X-ray power law extrapolated backward in energy agrees with the IR flux level. Corbel & Fender later showed that the typical hard-state radio power law extrapolated forward in energy meets the backward-extrapolated X-ray power law at an IR spectral break, which ...
Nowak, M.   +5 more
openaire   +3 more sources

Interdiffusion in the Ir-Rich Solid Solutions of Ir-Pt, Ir-Rh, and Ir-Re Binary Alloys [PDF]

open access: yesJournal of Phase Equilibria and Diffusion, 2011
Interdiffusivity in the Ir-rich solid solutions of Ir-X (X = Pt, Rh and Re) binary alloys was investigated in the temperature range of 2073-2373 K. The interdiffusion coefficients within the solute concentration range up to 10 at.% were evaluated through conventional diffusion-couple experiments.
Sekido, Nobuaki   +4 more
openaire   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

¿Desde lejos no se ve? Conectando territorios a partir de las relaciones visuales entre el arte rupestre de Los Llanos de La Rioja y el Noroeste argentino

open access: yesRelaciones de la Sociedad Argentina de Antropología, 2023
En la década de 1940 Salvador Canals Frau propuso que las sociedades prehispánicas que habitaron el área de Los Llanos riojanos habrían permanecido aisladas de otras poblaciones vecinas, generando una cultura material, una lengua y una identidad propias.
Ezequiel Gilardenghi   +4 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Polypyrimidine tract binding protein-1 (PTB1) is a determinant of the tissue and host tropism of a human rhinovirus/poliovirus chimera PV1(RIPO). [PDF]

open access: yesPLoS ONE, 2013
The internal ribosomal entry site (IRES) of picornavirus genomes serves as the nucleation site of a highly structured ribonucleoprotein complex essential to the binding of the 40S ribosomal subunit and initiation of viral protein translation.
Nusrat Jahan   +2 more
doaj   +1 more source

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