Results 11 to 20 of about 78,348 (310)

A bicistronic viral genome uses a compact type IV IRES near its 3′ end to express a transmembrane protein [PDF]

Cell Reports
Summary: Hepatitis C virus (HCV) and many other RNA viruses contain a type IV internal ribosome entry site (IRES) in their 5′ untranslated region (UTR). These IRES RNAs interact directly with the ribosome, enabling cap-independent translation initiation.
Madeline E. Sherlock, Katherine E. Segar, Jeffrey S. Kieft   +2 more
doaj   +2 more sources

Functional Analysis of the Halastavi árva Virus (HalV) Internal Ribosome Entry Site [PDF]

Viruses
Viral internal ribosome entry sites (IRESs) are specialized RNA structures that facilitate cap-independent translation as a strategy to usurp the host translational machinery.
Subash Chapagain, Lauren F. Woodburn, Natalie C. J. Strynadka, Eric Jan   +3 more
doaj   +2 more sources

Enhancing Circular RNA Translation Efficiency Through Dual Internal Ribosome Entry Sites [PDF]

Biology
Circular RNA (circRNA) has emerged as a promising vector for drug delivery because, unlike linear mRNA, it does not require costly chemical modifications and offers greater stability and sustained expression in cells.
Yawen Sun, Yimin Zhang, Weijie Chen, Ting Chen, Yunlong Zhang, Shanyu Zhang, Changrui Lu   +6 more
doaj   +2 more sources

Insights into Structural and Mechanistic Features of Viral IRES Elements

Frontiers in Microbiology, 2018
Internal ribosome entry site (IRES) elements are cis-acting RNA regions that promote internal initiation of protein synthesis using cap-independent mechanisms.
Encarnacion Martínez-Salas, Rosario Francisco-Velilla, Javier Fernandez-Chamorro   +2 more
exaly   +3 more sources

Comparison of the Regulatory Effects of Host Factors on Viral Internal Ribosomal Entry Sites [PDF]

Veterinary Sciences
Host factors play critical roles in viral IRES-mediated translation by modulating the efficiency and specificity of viral protein synthesis. In this study, we used small interfering RNA (siRNA) treatment to silence and plasmid-based expression to ...
Rupaly Akhter, Kazi Anowar Hossain, Bouchra Kitab, Mohammad Enamul Hoque Kayesh, Kyoko Tsukiyama-Kohara   +4 more
doaj   +2 more sources

Life cycle assessment of advanced building materials towards NZEBs [PDF]

E3S Web of Conferences, 2022
Buildings are responsible for 40% of energy consumption annually in Europe, along with the respective greenhouse gas emissions. To mitigate these impacts, intensive research is ongoing in the sector of the Nearly Zero-Energy Buildings (NZEBs).
Antypa Despoina, Vlysidis Anestis, Gkika Anastasia, Petrakli Foteini, Kraft Robert, Böhm Robert, Eckert Kathrin Marina, Smirnova Irina, Suchorzewski Jan, Koumoulos Elias   +9 more
doaj   +1 more source

Ferritin Iron Responsive Elements (IREs) mRNA Interacts with eIF4G and Activates In Vitro Translation

Frontiers in Bioscience-Elite, 2022
Background: Eukaryotic initiation factor (eIF) 4G plays an important role in assembling the initiation complex required for ribosome binding to mRNA and promote translation.
Mateen A. Khan
doaj   +1 more source

On the Relation Between Active Network Length and Catchment Discharge

Geophysical Research Letters, 2022
The ever‐changing hydroclimatic conditions of the landscape induce ceaseless variations in the wet channel length (L) and the streamflow (Q) of a catchment.
Nicola Durighetto, Gianluca Botter
doaj   +1 more source

Intensive Agriculture as Climate Change Adaptation? Economic and Environmental Tradeoffs in Securing Rural Livelihoods in Tanzanian River Basins

Frontiers in Environmental Science, 2021
Tanzania is one of the East African countries most vulnerable to climate change impacts. Droughts and floods in 2015–16 had devastating effects on food production, crop failures and livestock deaths reaching record levels.
Idil Ires, Idil Ires
doaj   +1 more source

A novel Bcr-Abl–mTOR–eIF4A axis regulates IRES-mediated translation of LEF-1 [PDF]

Open Biology, 2014
Internal ribosome entry sites (IRESs) in cellular mRNAs direct expression of growth-promoting factors through an alternative translation mechanism that has yet to be fully defined.
Becky Pinjou Tsai, Judith Jimenez, Sharon Lim, Kerry D. Fitzgerald, Min Zhang, Charles T. H. Chuah, Haley Axelrod, Luke Nelson, S. Tiong Ong, Bert L. Semler, Marian L. Waterman   +10 more
doaj   +1 more source