Results 51 to 60 of about 57,500 (285)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Organometallic half-sandwich iridium anticancer complexes [PDF]

, 2011
The low-spin 5d6 IrIII organometallic half-sandwich complexes [(η5-Cpx)Ir(XY)Cl]0/+, Cpx = Cp*, tetramethyl(phenyl)cyclopentadienyl (Cpxph), or tetramethyl(biphenyl)cyclopentadienyl (Cpxbiph), XY = 1,10-phenanthroline (4−6), 2,2′-bipyridine (7−9 ...
Liu, Zhe, Bruijnincx, P.C.A., Brabec, V., Clarkson, Guy J., Sally A. Fletcher, Liu, Z., Vrana, O., Guy J. Clarkson, Fletcher, Sally A., Vrana, Oldrich, Salassa, Luca, Brabec, V. (Viktor), Fletcher, S.A., Kisova, A., Peter J. Sadler, Clarkson, G.J., Pizarro, A.M., Viktor Brabec, Bruijnincx, Pieter C. A., Oldrich Vrana, Sadler, P. J., Pieter C. A. Bruijnincx, Zhe Liu, Salassa, L., Luca Salassa, Habtemariam, A., Inorganic Chemistry and Catalysis, Sub Inorganic Chemistry and Catalysis, Pizarro, Ana M., Sadler, Peter J., Ana M. Pizarro, Kisova, Anna, Habtemariam, Abraha, Abraha Habtemariam, Anna Kisova   +34 more
core   +2 more sources

Quantifying manual editing time in autocontouring via audit log analysis

Physics and Imaging in Radiation Oncology
Background and purpose: Artificial intelligence (AI)-based contouring reduces delineation workload, yet manual corrections remain required. Reliable, scalable quantification of structure-level editing time is needed to evaluate clinical usability beyond ...
Geert De Kerf, Gabriele Balletti, Nina Menten, Michaël Claessens, Thibaut D'homme, Joachim Marichal, Mark J. Gooding, Dirk Verellen   +7 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A Panchromatic Cyclometalated Iridium Dye Based on 2-Thienyl-Perimidine

Molecules, 2022
Though 2-arylperimidines have never been used in iridium(III) chemistry, the present study on structural, electronic and optical properties of N-unsubstituted and N-methylated 2-(2-thienyl)perimidines, supported by DFT/TDDFT calculations, has shown that ...
Paulina Kalle, Marina A. Kiseleva, Sergei V. Tatarin, Daniil E. Smirnov, Alexander Y. Zakharov, Viktor V. Emets, Andrei V. Churakov, Stanislav I. Bezzubov   +7 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Automated evaluation of organ sparing in prostate stereotactic body radiation therapy using dose-gradient metrics

Physics and Imaging in Radiation Oncology
Background and purpose: Traditional dose-volume histogram (DVH) metrics used in radiotherapy plan evaluation lack spatial information and are sensitive to organ volume variations. This study investigated the use of Dose Gradient Curves (DGCs) as a robust,
Geert De Kerf, Michaël Claessens, Thibaut D’homme, Piet Dirix, Piet Ost, Dirk Verellen   +5 more
doaj   +1 more source

Sub-monolayers of iridium electrodeposited on Ti2AlC substrate as catalysts for hydrogen evolution reaction in sulfuric acid solution

Zaštita Materijala, 2020
The hydrogen evolution reaction (HER) was investigated at sub-monolayers of iridium electrodeposited on Ti2AlC substrate. The lowest amount of electrodeposited iridium was 3 close-packed (111) monolayers (3 ML), while the highest one was 22 ML (3, 5, 10,
Vladimir D. Jović, Pajić Mila N. Krstajić   +1 more
doaj   +1 more source

Nano-metal diborides-supported anode catalyst with strongly coupled TaOx/IrO2 catalytic layer for low-iridium-loading proton exchange membrane electrolyzer

Nature Communications, 2023
The sluggish kinetics of oxygen evolution reaction (OER) and high iridium loading in catalyst coated membrane (CCM) are the key challenges for practical proton exchange membrane water electrolyzer (PEMWE).
Yuannan Wang, Mingcheng Zhang, Zhenye Kang, Lei Shi, Yucheng Shen, Boyuan Tian, Yongcun Zou, Hui Chen, Xiaoxin Zou   +8 more
doaj   +1 more source