Results 51 to 60 of about 59,836 (250)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Iridium-Catalyzed Cyclization of Isoxazolines and Alkenes: Divergent Access to Pyrrolidines, Pyrroles, and Carbazoles

, 2016
A heterogeneous iridium-complex-catalyzed N–O-cleaving rearrangement/cyclization of 2,3-dihydroisoxazoles with alkenes has been developed. It provides divergent access to multiple substituted pyrrolidines, pyrroles, and carbazoles.
Zu-Feng Xiao (1457725), Xiao-Shan Ning (1457722), Ting-Hui Ding (3238431), Yan-Biao Kang (1433758), Sheng-Wei Mao (3238428), Zaher Shah (3238425)   +5 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Iridium-Catalyzed Reductive Nucleophilic Addition to Secondary Amides

, 2018
An iridium-catalyzed reductive nucleophilic addition to secondary amides is reported. After the iridium-catalyzed reduction, the resulting imines can undergo the Strecker reaction, the Mannich reaction, allylation, and [3 + 2]-cycloaddition.
Yoshito Takahashi (4675366), Takaaki Sato (1573465), Yoshito Takahashi, Takaaki Sato, Noritaka Chida, Risa Yoshii (5729264), Noritaka Chida (1617391), Risa Yoshii   +7 more
core   +1 more source

Stereotactic body radiotherapy (SBRT) as a treatment for localized prostate cancer: a retrospective analysis

Radiation Oncology
Background External beam radiotherapy (EBRT) is a standard treatment for localized prostate cancer, with recent advancements favoring a reduced number of treatment sessions.
Brecht De Cooman, Tibaut Debacker, Thomas Adams, Guy Lamberts, Bart De Troyer, Marc Claessens, Geert De Kerf, Carole Mercier, Piet Dirix, Piet Ost   +9 more
doaj   +1 more source

Multi-institutional generalizability of a plan complexity machine learning model for predicting pre-treatment quality assurance results in radiotherapy

Physics and Imaging in Radiation Oncology
Background and purpose: Treatment plans in radiotherapy are subject to measurement-based pre-treatment verifications. In this study, plan complexity metrics (PCMs) were calculated per beam and used as input features to develop a predictive model. The aim
Michaël Claessens, Geert De Kerf, Verdi Vanreusel, Isabelle Mollaert, Victor Hernandez, Jordi Saez, Núria Jornet, Dirk Verellen   +7 more
doaj   +1 more source

Nano-metal diborides-supported anode catalyst with strongly coupled TaOx/IrO2 catalytic layer for low-iridium-loading proton exchange membrane electrolyzer

Nature Communications, 2023
The sluggish kinetics of oxygen evolution reaction (OER) and high iridium loading in catalyst coated membrane (CCM) are the key challenges for practical proton exchange membrane water electrolyzer (PEMWE).
Yuannan Wang, Mingcheng Zhang, Zhenye Kang, Lei Shi, Yucheng Shen, Boyuan Tian, Yongcun Zou, Hui Chen, Xiaoxin Zou   +8 more
doaj   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Iridium-Catalyzed Asymmetric Transfer Hydrogenation of Alkynyl Ketones Using Sodium Formate and Ethanol as Hydrogen Sources

, 2018
A green and efficient iridium-catalyzed asymmetric transfer hydrogenation of alkynyl ketones to chiral propargylic alcohols has been developed. By using sodium formate and ethanol as hydrogen sources, a series of alkynyl ketones were hydrogenated by ...
Jian-Hua Xie, Wei-Peng Liu (2327986), Qi-Lin Zhou, Yang-Ming Zhang (1792741), Ming-Lei Yuan (2733058), Ming-Lei Yuan, Qi-Lin Zhou (1434034), Yang-Ming Zhang, Jian-Hua Xie (1434019), Wei-Peng Liu   +9 more
core   +1 more source

Iridium-Catalyzed Intramolecular β‑C–H Alkenylation of Ketones with Alkynes via a Hydride-Transfer Approach

, 2022
Direct functionalization of carbonyl β C–H bonds without using directing groups has not been a trivial task, and it is even more challenging to realize the corresponding atom-economical transformations with common alkenes or alkynes as the coupling ...
Bo Zhou (15092), Shuang Deng (3435830), Xiaotian Qi (1425286), Yin Xu (159474), Guangbin Dong (1288614)   +4 more
core   +1 more source