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Stability of irinotecan hydrochloride in aqueous solutions
American Journal of Health-System Pharmacy, 2002The stability of irinotecan after reconstitution in several vehicles for i.v. infusion was studied. Irinotecan hydrochloride injection was diluted in phosphate buffer solution (pH 4.0, 6.0, and 7.4), 5% dextrose injection, and 0.9% sodium chloride injection to a final concentration of 20 micrograms/mL.
Robert T Koda
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Simultaneous quantification of Gemcitabine and Irinotecan hydrochloride in rat plasma by using high performance liquid chromatography-diode array detector [PDF]
Journal of Pharmaceutical and Biomedical Analysis, 2018 In this manuscript we aimed at the simultaneous separation and quantification of Gemcitabine and Irinotecan hydrochloride (injected both as single components and in combination) from Sprague Dawley rat plasma by using a validated method obtained through ...
Donato Cosco +2 more
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Biophysical and molecular docking insight into interaction mechanism and thermal stability of human serum albumin isoforms with a semi-synthetic water-soluble camptothecin analog irinotecan hydrochloride [PDF]
Journal of Biomolecular Structure and Dynamics, 2016 In the present work, we have examined the binding parameters, thermodynamics, and stability of human serum albumin (HSA) isoforms at pH 7.4 and 9.0, using spectroscopic, calorimetric, and molecular docking methods in the presence of water-soluble ...
Mohd Ishtikhar +2 more
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Synthesis of CPT‐11 (Irinotecan Hydrochloride Trihydrate) [PDF]
Annals of the New York Academy of Sciences, 1996 S, Sawada, T, Yokokura, T, Miyasaka
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