Results 1 to 10 of about 39,854 (281)

Evaluation of two models for human topoisomerase I interaction with dsDNA and camptothecin derivatives. [PDF]

PLoS ONE, 2011
Human topoisomerase I (Top1) relaxes supercoiled DNA during cell division. Camptothecin stabilizes Top1/dsDNA covalent complexes which ultimately results in cell death, and this makes Top1 an anti-cancer target.
Gary S Laco
doaj   +2 more sources

Genome-wide transcriptional effects of the anti-cancer agent camptothecin. [PDF]

PLoS ONE, 2013
The anti-cancer drug camptothecin inhibits replication and transcription by trapping DNA topoisomerase I (Top1) covalently to DNA in a "cleavable complex".
Artur Veloso, Benjamin Biewen, Michelle T Paulsen, Nathan Berg, Leonardo Carmo de Andrade Lima, Jayendra Prasad, Karan Bedi, Brian Magnuson, Thomas E Wilson, Mats Ljungman   +9 more
doaj   +2 more sources

Screening and selection of camptothecin producing endophytes from Nothapodytes nimmoniana

Scientific Reports, 2021
Endophytic fungi with the ability to produce plant based secondary metabolites are a potential alternative for producing the host plant metabolite and to prevent natural plants from extinction. To isolate a high metabolite yielding endophytic strain from
I. A. H. Khwajah Mohinudeen, Saumya Pandey, Hemalatha Kanniyappan, Vignesh Muthuvijayan, Smita Srivastava   +4 more
doaj   +1 more source

Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis

Nature Communications, 2021
Plant genomes remain highly fragmented and are often characterized by hundreds to thousands of assembly gaps. Here, we report chromosome-level reference and phased genome assembly of Ophiorrhiza pumila, a camptothecin-producing medicinal plant, through ...
A. Rai, H. Hirakawa, Ryo Nakabayashi, S. Kikuchi, Koki Hayashi, Megha Rai, H. Tsugawa, Taiki Nakaya, Tetsuya Mori, Hideki Nagasaki, Runa Fukushi, Y. Kusuya, Hiroki Takahashi, H. Uchiyama, A. Toyoda, S. Hikosaka, E. Goto, K. Saito, M. Yamazaki   +18 more
semanticscholar   +1 more source

Identification of WRKY transcription factors involved in regulating the biosynthesis of the anti-cancer drug camptothecin in Ophiorrhiza pumila

Horticulture Research, 2022
Camptothecin is a chemotherapeutic drug widely used to treat various cancers. Ophiorrhiza pumila is an ideal plant model for the study of camptothecin production, with various advantages for studying camptothecin biosynthesis and regulation.
Can Wang, Xiaolong Hao, Yao Wang, I. Maoz, Wei Zhou, Zhigang Zhou, Guoying Kai   +6 more
semanticscholar   +1 more source

CFS-1686 causes cell cycle arrest at intra-S phase by interference of interaction of topoisomerase 1 with DNA. [PDF]

PLoS ONE, 2014
CFS-1686 (chemical name (E)-N-(2-(diethylamino)ethyl)-4-(2-(2-(5-nitrofuran-2-yl)vinyl)quinolin-4-ylamino)benzamide) inhibits cell proliferation and triggers late apoptosis in prostate cancer cell lines.
Ru-Wei Lin, Chia-Ning Yang, ShengYu Ku, Cheng-Jung Ho, Shih-Bo Huang, Min-Chi Yang, Hsin-Wen Chang, Chun-Mao Lin, Jaulang Hwang, Yeh-Long Chen, Cherg-Chyi Tzeng, Chihuei Wang   +11 more
doaj   +1 more source

Proteomics and metabolomics analyses of camptothecin-producing Aspergillus terreus reveal the integration of PH domain-containing proteins and peptidylprolyl cis/trans isomerase in restoring the camptothecin biosynthesis

Microbiology Spectrum, 2023
Attenuating the expression of fungal camptothecin biosynthetic genes with subculturing is the challenge that halts their further implementation. The camptothecin productivity of the subcultured Aspergillus terreus has been restored upon addition of Ficus
Amgad M. Rady, Ashraf S. A. El-Sayed, Ashraf F. El-Baz, Ghada G. Abdel-Fattah, Sameh Magdeldin, Eman Ahmed, Aya Osama, Sameh E. Hassanein, Hend Saed, Marwa Yassin   +9 more
doaj   +1 more source

The transcription factor OpWRKY2 positively regulates the biosynthesis of the anticancer drug camptothecin in Ophiorrhiza pumila

Horticulture Research, 2021
The limited bioavailability of plant-derived natural products with anticancer activity poses major challenges to the pharmaceutical industry. An example of this is camptothecin, a monoterpene indole alkaloid with potent anticancer activity that is ...
Xiaolong Hao, Chenhong Xie, Qingyan Ruan, Xi-chen Zhang, Chao Wu, Bing Han, J. Qian, Wei Zhou, Hans-Wilhelm Nützmann, G. Kai   +9 more
semanticscholar   +1 more source

Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I. [PDF]

PLoS ONE, 2014
The CD44+ and CD44- subpopulations of the colorectal cancer cell line Caco2 were analyzed separately for their sensitivities to the antitumor drug camptothecin. CD44+ cells were less sensitive to camptothecin than CD44- cells.
Amit Roy, Cinzia Tesauro, Rikke Frøhlich, Marianne S Hede, Maria J Nielsen, Eigil Kjeldsen, Bjarne Bonven, Magnus Stougaard, Irina Gromova, Birgitta R Knudsen   +9 more
doaj   +1 more source

Characterization of camptothecin by analytical methods and determination of anticancer potential against prostate cancer

Future Journal of Pharmaceutical Sciences, 2021
Background Objective of present research work is to develop and validate cost-effective analytical tool for determination of camptothecin (CPT) and determine its anticancer potential against prostate cancer LNCaP cell lines.
Sunil T. Galatage, Rahul Trivedi, Durgacharan A. Bhagwat   +2 more
doaj   +1 more source