Results 1 to 10 of about 18,515 (223)

Production, Bioprocessing and Anti-Proliferative Activity of Camptothecin from Penicillium chrysogenum, “An Endozoic of Marine Sponge, Cliona sp.”, as a Metabolically Stable Camptothecin Producing Isolate

Molecules, 2022
Exploring the metabolic potency of fungi as camptothecin producers raises the hope of their usage as an industrial source of camptothecin, due to their short-life span and the feasibility of metabolic engineering.
Ashraf S. A. El-Sayed, Wafaa H. B. Hassan, Sherouk Hussein Sweilam, Mohammed Hamed Saeed Alqarni, Zeinab I. El Sayed, Mahmoud M. Abdel-Aal, Eman Abdelsalam, Sahar Abdelaziz   +7 more
doaj   +3 more sources

Genomic and transcriptomic analysis of camptothecin producing novel fungal endophyte: Alternaria burnsii NCIM 1409

Scientific Reports, 2023
Camptothecin is an important anticancer alkaloid produced by particular plant species. No suitable synthetic route has been established for camptothecin production yet, imposing a stress on plant-based production systems. Endophytes associated with these
Shakunthala Natarajan, Boas Pucker, Smita Srivastava   +2 more
doaj   +3 more sources

Production and bioprocessing of camptothecin from Aspergillus terreus, an endophyte of Cestrum parqui, restoring their biosynthetic potency by Citrus limonum peel extracts

Microbial Cell Factories, 2023
The metabolic potency of fungi as camptothecin producer elevates their prospective use as an industrial platform for commercial production, however, the loss of camptothecin productivity by fungi with the storage and subculturing are the major obstacle ...
Ashraf S. A. El-Sayed, Nelly M. George, Amira Abou-Elnour, Rasha M. El-Mekkawy, Marwa M. El-Demerdash   +4 more
doaj   +2 more sources

A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis

Nature Communications, 2021
Camptothecin is a monoterpene indole alkaloid with anti-tumor activity. Here, the authors assemble the genome of the camptothecin producing plant Camptotheca acuminata and provide insights into the evolutionary origin of camptothecin biosynthesis by ...
Minghui Kang, Rao Fu, Pingyu Zhang, Shangling Lou, Xuchen Yang, Yang Chen, Tao Ma, Yang Zhang, Zhenxiang Xi, Jianquan Liu   +9 more
doaj   +2 more sources

Screening and selection of camptothecin producing endophytes from Nothapodytes nimmoniana

Scientific Reports, 2021
Endophytic fungi with the ability to produce plant based secondary metabolites are a potential alternative for producing the host plant metabolite and to prevent natural plants from extinction. To isolate a high metabolite yielding endophytic strain from
I. A. H. Khwajah Mohinudeen, Saumya Pandey, Hemalatha Kanniyappan, Vignesh Muthuvijayan, Smita Srivastava   +4 more
doaj   +2 more sources

Sustainable production of camptothecin from an Alternaria sp. isolated from Nothapodytes nimmoniana

Scientific Reports, 2021
Camptothecin the third most in demand alkaloid, is commercially extracted in India from the endangered plant, Nothapodytes nimmoniana. Endophytes, the microorganisms that reside within plants, are reported to have the ability to produce host–plant ...
I. A. H. Khwajah Mohinudeen, Rahul Kanumuri, K. N. Soujanya, R. Uma Shaanker, Suresh Kumar Rayala, Smita Srivastava   +5 more
doaj   +2 more sources

Characterization of camptothecin by analytical methods and determination of anticancer potential against prostate cancer

Future Journal of Pharmaceutical Sciences, 2021
Background Objective of present research work is to develop and validate cost-effective analytical tool for determination of camptothecin (CPT) and determine its anticancer potential against prostate cancer LNCaP cell lines.
Sunil T. Galatage, Rahul Trivedi, Durgacharan A. Bhagwat   +2 more
doaj   +2 more sources

Discovering and harnessing oxidative enzymes for chemoenzymatic synthesis and diversification of anticancer camptothecin analogues

Communications Chemistry, 2021
Camptothecin derivatives are precursors of potent anticancer agents, but their biosynthesis remains largely unknown. Here two cytochrome P450 monooxygenases are shown to regiospecifically oxidize camptothecin, yielding 10- and 11- hydroxylated ...
Tuan-Anh M. Nguyen, Trinh-Don Nguyen, Yuen Yee Leung, Matthew McConnachie, Oleg Sannikov, Zhicheng Xia, Thu-Thuy T. Dang   +6 more
doaj   +2 more sources

Molecular Docking and Pharmacological In Silico Evaluation of Camptothecin and Related Ligands as Promising HER2-Targeted Therapies for Breast Cancer

Current Issues in Molecular Biology
Breast cancer is one of the leading causes of cancer-related mortality in women worldwide, highlighting the importance of effective therapies. This study evaluates the interaction between camptothecin, a potent anticancer agent, and two key receptors ...
Elmer Joel Millan-Casarrubias, Yunia Verónica García-Tejeda, Claudia Haydée González-De la Rosa, Lucero Ruiz-Mazón, Yazmín Mariela Hernández-Rodríguez, Oscar Eduardo Cigarroa-Mayorga   +5 more
doaj   +2 more sources

Total Synthesis, Mechanism of Action, and Antitumor Efficacy of Camptothecin and Some of its Analogues

Anti-Cancer Agents in Medicinal Chemistry, 2022
Over the past 55 years of research, various experimental methods have been developed for the total synthesis of the anticancer camptothecin, a potent antitumor antibiotic, and its numerous active derivatives.
Valeriy Bacherikov
exaly   +2 more sources