Results 11 to 20 of about 39,854 (281)
Molecules, 2022 Exploring the metabolic potency of fungi as camptothecin producers raises the hope of their usage as an industrial source of camptothecin, due to their short-life span and the feasibility of metabolic engineering.
Ashraf S. A. El-Sayed +7 more
doaj +3 more sources
Scientific Reports, 2023 Camptothecin is an important anticancer alkaloid produced by particular plant species. No suitable synthetic route has been established for camptothecin production yet, imposing a stress on plant-based production systems. Endophytes associated with these
Shakunthala Natarajan +2 more
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Microbial Cell Factories, 2023 The metabolic potency of fungi as camptothecin producer elevates their prospective use as an industrial platform for commercial production, however, the loss of camptothecin productivity by fungi with the storage and subculturing are the major obstacle ...
Ashraf S. A. El-Sayed +4 more
doaj +2 more sources
Safe approaches for camptothecin delivery: Structural analogues and nanomedicines [PDF]
Journal of Controlled Release, 2017 Twenty‐(S)‐camptothecin is a strongly cytotoxic molecule with excellent antitumor activity over a wide spectrum of human cancers. However, the direct formulation is limited by its poor water solubility, low plasmatic stability and severe toxicity, which ...
Pablo Botella, Eva Rivero-Buceta
exaly +3 more sources
Nature Communications, 2021 Camptothecin is a monoterpene indole alkaloid with anti-tumor activity. Here, the authors assemble the genome of the camptothecin producing plant Camptotheca acuminata and provide insights into the evolutionary origin of camptothecin biosynthesis by ...
Minghui Kang +9 more
doaj +2 more sources
Sustainable production of camptothecin from an Alternaria sp. isolated from Nothapodytes nimmoniana
Scientific Reports, 2021 Camptothecin the third most in demand alkaloid, is commercially extracted in India from the endangered plant, Nothapodytes nimmoniana. Endophytes, the microorganisms that reside within plants, are reported to have the ability to produce host–plant ...
I. A. H. Khwajah Mohinudeen +5 more
doaj +2 more sources
Communications Chemistry, 2021 Camptothecin derivatives are precursors of potent anticancer agents, but their biosynthesis remains largely unknown. Here two cytochrome P450 monooxygenases are shown to regiospecifically oxidize camptothecin, yielding 10- and 11- hydroxylated ...
Tuan-Anh M. Nguyen +6 more
doaj +2 more sources
Design and characterization of camptothecin gel for treatment of epidermoid carcinoma
Future Journal of Pharmaceutical Sciences, 2020 Background The objective of present research work is to design and characterize camptothecin gel using Carbopol-934 for the treatment of epidermoid carcinoma.
Sunil T. Galatage +6 more
doaj +2 more sources
PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system [PDF]
Beilstein Journal of Nanotechnology, 2014 Camptothecin (CPT; (S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione) is a highly cytotoxic natural alkaloid that has not yet found use as chemotherapeutic agent due to its poor water-solubility and chemical ...
Paula M. Castillo +4 more
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Journal of Integrative Plant Biology, 2023 Camptothecin is one of the most commonly used anticancer drugs worldwide, yet the downstream biosynthetic route from strictosidine to camptothecin has remained unclear for more than half a century.
Tong Zhang +7 more
semanticscholar +1 more source