Results 11 to 20 of about 18,515 (223)
Genome-wide transcriptional effects of the anti-cancer agent camptothecin. [PDF]
PLoS ONE, 2013 The anti-cancer drug camptothecin inhibits replication and transcription by trapping DNA topoisomerase I (Top1) covalently to DNA in a "cleavable complex".
Artur Veloso +9 more
doaj +2 more sources
Evaluation of two models for human topoisomerase I interaction with dsDNA and camptothecin derivatives. [PDF]
PLoS ONE, 2011 Human topoisomerase I (Top1) relaxes supercoiled DNA during cell division. Camptothecin stabilizes Top1/dsDNA covalent complexes which ultimately results in cell death, and this makes Top1 an anti-cancer target.
Gary S Laco
doaj +2 more sources
Design and characterization of camptothecin gel for treatment of epidermoid carcinoma
Future Journal of Pharmaceutical Sciences, 2020 Background The objective of present research work is to design and characterize camptothecin gel using Carbopol-934 for the treatment of epidermoid carcinoma.
Sunil T. Galatage +6 more
doaj +2 more sources
PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system [PDF]
Beilstein Journal of Nanotechnology, 2014 Camptothecin (CPT; (S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione) is a highly cytotoxic natural alkaloid that has not yet found use as chemotherapeutic agent due to its poor water-solubility and chemical ...
Paula M. Castillo +4 more
doaj +3 more sources
Preprint: Actions of camptothecin derivatives on larvae and adults of the arboviral vector Aedes aegypti [PDF]
, 2021 Mosquito-borne viruses including dengue, Zika and Chikungunya viruses as well as parasites such as malaria and Onchocerca volvulus endanger health and economic security around the globe and emerging mosquito-borne pathogens have pandemic potential ...
Lycett, G. +8 more
core +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Fowl adenovirus serotype 4 (FAdV-4) caused hepatitis–hydropericardium syndrome in poultry and caused huge economic losses to the poultry industry. At present, antiviral drugs have not been reported to be effective against this virus, and new treatment ...
Dongdong Yin +11 more
doaj +1 more source
Nature Nanotechnology, 2021 Despite the enormous therapeutic potential of immune checkpoint blockade (ICB), it benefits only a small subset of patients. Some chemotherapeutics can switch ‘immune-cold’ tumours to ‘immune-hot’ to synergize with ICB.
Zhiren Wang +7 more
semanticscholar +1 more source
Nature Communications, 2021 Plant genomes remain highly fragmented and are often characterized by hundreds to thousands of assembly gaps. Here, we report chromosome-level reference and phased genome assembly of Ophiorrhiza pumila, a camptothecin-producing medicinal plant, through ...
A. Rai +18 more
semanticscholar +1 more source
Glutathione‐Responsive Nanoparticles of Camptothecin Prodrug for Cancer Therapy
Advancement of science, 2022 Camptothecin (CPT) is a potent chemotherapeutic agent for various cancers, but the broader application of CPT is still hindered by its poor bioavailability and systemic toxicity.
Ling-Pu Zhang +9 more
semanticscholar +1 more source
Horticulture Research, 2022 Camptothecin is a chemotherapeutic drug widely used to treat various cancers. Ophiorrhiza pumila is an ideal plant model for the study of camptothecin production, with various advantages for studying camptothecin biosynthesis and regulation.
Can Wang +6 more
semanticscholar +1 more source