Results 11 to 20 of about 23,580 (195)

Genome-wide transcriptional effects of the anti-cancer agent camptothecin. [PDF]

PLoS ONE, 2013
The anti-cancer drug camptothecin inhibits replication and transcription by trapping DNA topoisomerase I (Top1) covalently to DNA in a "cleavable complex".
Artur Veloso, Benjamin Biewen, Michelle T Paulsen, Nathan Berg, Leonardo Carmo de Andrade Lima, Jayendra Prasad, Karan Bedi, Brian Magnuson, Thomas E Wilson, Mats Ljungman   +9 more
doaj   +1 more source

Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I. [PDF]

PLoS ONE, 2014
The CD44+ and CD44- subpopulations of the colorectal cancer cell line Caco2 were analyzed separately for their sensitivities to the antitumor drug camptothecin. CD44+ cells were less sensitive to camptothecin than CD44- cells.
Amit Roy, Cinzia Tesauro, Rikke Frøhlich, Marianne S Hede, Maria J Nielsen, Eigil Kjeldsen, Bjarne Bonven, Magnus Stougaard, Irina Gromova, Birgitta R Knudsen   +9 more
doaj   +1 more source

Characterization of camptothecin by analytical methods and determination of anticancer potential against prostate cancer

Future Journal of Pharmaceutical Sciences, 2021
Background Objective of present research work is to develop and validate cost-effective analytical tool for determination of camptothecin (CPT) and determine its anticancer potential against prostate cancer LNCaP cell lines.
Sunil T. Galatage, Rahul Trivedi, Durgacharan A. Bhagwat   +2 more
doaj   +1 more source

Advances on the camptothecin biosynthesis

上海师范大学学报. 自然科学版, 2018
Camptothecin is an indole alkaloid with anticancer activity extracted from woodyplant Camptotheca acuminata.The extremely low annual production of camptothecin makes it very expensive,so increasing the yield of camptothecin is an urgent problem to be ...
XU Ziyan, PAN Jingxian, QIAN Zhongying, CUI Lijie   +3 more
doaj   +1 more source

Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition

Communications Biology, 2022
Non-camptothecin topoisomerase I inhibitor, Genz, shows potent activity against camptothecin-resistant cells through double-strand break induced cytotoxicity.
Masahiro Nishida, Takeshi Terabayashi, Shigeru Matsuoka, Tomoko Okuma, Sawako Adachi, Tadashi Tomo, Masanori Kawano, Kazuhiro Tanaka, Hiroshi Tsumura, Hirofumi Anai, Toshimasa Ishizaki, Yoshihiro Nishida, Katsuhiro Hanada   +12 more
doaj   +1 more source

Synthesis, Experimental and Density Functional Theory (DFT) Studies on Solubility of Camptothecin Derivatives

Molecules, 2018
Two camptothecin derivatives, 10-cyclohexyl-7-methyl-20(S)-camptothecin and 7-methyl-10-morpholino-20(S)-camptothecin, were synthesized and their differences in solubility were investigated using four chosen solvent systems.
Chin-Hung Lai, Chia-Chin Chang, Yi-Lin Weng, Ta-Hsien Chuang   +3 more
doaj   +1 more source

Discovering and harnessing oxidative enzymes for chemoenzymatic synthesis and diversification of anticancer camptothecin analogues

Communications Chemistry, 2021
Camptothecin derivatives are precursors of potent anticancer agents, but their biosynthesis remains largely unknown. Here two cytochrome P450 monooxygenases are shown to regiospecifically oxidize camptothecin, yielding 10- and 11- hydroxylated ...
Tuan-Anh M. Nguyen, Trinh-Don Nguyen, Yuen Yee Leung, Matthew McConnachie, Oleg Sannikov, Zhicheng Xia, Thu-Thuy T. Dang   +6 more
doaj   +1 more source

Formation of nanoparticles by cooperative inclusion between (S)-camptothecin-modified dextrans and β-cyclodextrin polymers

Beilstein Journal of Organic Chemistry, 2015
Novel (S)-camptothecin–dextran polymers were obtained by “click” grafting of azide-modified (S)-camptothecin and alkyne-modified dextrans. Two series based on 10 kDa and 70 kDa dextrans were prepared with a degree of substitution of (S)-camptothecin ...
Thorbjørn Terndrup Nielsen, Catherine Amiel, Laurent Duroux, Kim Lambertsen Larsen, Lars Wagner Städe, Reinhard Wimmer, Véronique Wintgens   +6 more
doaj   +1 more source

Design and characterization of camptothecin gel for treatment of epidermoid carcinoma

Future Journal of Pharmaceutical Sciences, 2020
Background The objective of present research work is to design and characterize camptothecin gel using Carbopol-934 for the treatment of epidermoid carcinoma.
Sunil T. Galatage, Aditya S. Hebalkar, Raviraj V. Gote, Omkar R. Mali, Suresh G. Killedar, Durgacharan A. Bhagwat, Vijay M. Kumbhar   +6 more
doaj   +1 more source

Enhanced Stability and Bioactivity of Natural Anticancer Topoisomerase I Inhibitors through Cyclodextrin Complexation

Pharmaceutics, 2021
The use of cyclodextrins as drug nano-carrier systems for drug delivery is gaining importance in the pharmaceutical industry due to the interesting pharmacokinetic properties of the resulting inclusion complexes.
Víctor González-Ruiz, Ángel Cores, Olmo Martín-Cámara, Karen Orellana, Víctor Cervera-Carrascón, Patrycja Michalska, Ana I. Olives, Rafael León, M. Antonia Martín, J. Carlos Menéndez   +9 more
doaj   +1 more source