Results 21 to 30 of about 39,854 (281)

Preprint: Actions of camptothecin derivatives on larvae and adults of the arboviral vector Aedes aegypti [PDF]

, 2021
Mosquito-borne viruses including dengue, Zika and Chikungunya viruses as well as parasites such as malaria and Onchocerca volvulus endanger health and economic security around the globe and emerging mosquito-borne pathogens have pandemic potential ...
Lycett, G., Poulton, B., Partridge, F.A., Lees, R.A., Sattelle, D.B., Poulton, B.C., Lake, M.A.I., Mann, H-J., Lycett, G.J.   +8 more
core   +1 more source

Antiviral and Virucidal Activities of Camptothecin on Fowl Adenovirus Serotype 4 by Blocking Virus Replication

Frontiers in Cellular and Infection Microbiology, 2022
Fowl adenovirus serotype 4 (FAdV-4) caused hepatitis–hydropericardium syndrome in poultry and caused huge economic losses to the poultry industry. At present, antiviral drugs have not been reported to be effective against this virus, and new treatment ...
Dongdong Yin, Lei Yin, Jieru Wang, Xuehuai Shen, Yin Dai, Ruihong Zhao, Xiaomiao Hu, Hongyan Hou, Danjun Zhang, Guijun Wang, Kezong Qi, Xiaocheng Pan   +11 more
doaj   +1 more source

A Practical Six-Step Synthesis of (S)-Camptothecin

, 2016
An asymmetric synthesis of (S)-camptothecin (1) has been accomplished in six steps starting from two commercially available ...
Daniel L. Comins (222088), Jason M. Nolan (3034764)   +1 more
core   +2 more sources

Advances on the camptothecin biosynthesis

上海师范大学学报. 自然科学版, 2018
Camptothecin is an indole alkaloid with anticancer activity extracted from woodyplant Camptotheca acuminata.The extremely low annual production of camptothecin makes it very expensive,so increasing the yield of camptothecin is an urgent problem to be ...
XU Ziyan, PAN Jingxian, QIAN Zhongying, CUI Lijie   +3 more
doaj   +1 more source

Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition

Communications Biology, 2022
Non-camptothecin topoisomerase I inhibitor, Genz, shows potent activity against camptothecin-resistant cells through double-strand break induced cytotoxicity.
Masahiro Nishida, Takeshi Terabayashi, Shigeru Matsuoka, Tomoko Okuma, Sawako Adachi, Tadashi Tomo, Masanori Kawano, Kazuhiro Tanaka, Hiroshi Tsumura, Hirofumi Anai, Toshimasa Ishizaki, Yoshihiro Nishida, Katsuhiro Hanada   +12 more
doaj   +1 more source

Synthesis, Experimental and Density Functional Theory (DFT) Studies on Solubility of Camptothecin Derivatives

Molecules, 2018
Two camptothecin derivatives, 10-cyclohexyl-7-methyl-20(S)-camptothecin and 7-methyl-10-morpholino-20(S)-camptothecin, were synthesized and their differences in solubility were investigated using four chosen solvent systems.
Chin-Hung Lai, Chia-Chin Chang, Yi-Lin Weng, Ta-Hsien Chuang   +3 more
doaj   +1 more source

Targeted camptothecin delivery via silicon nanoparticles reduces breast cancer metastasis.

Biomaterials, 2020
In advanced breast cancer (BCa) patients, not the primary tumor, but the development of distant metastases, which occur mainly in the organ bone, and their adverse health effects are responsible for high mortality.
Marietta Landgraf, C. Lahr, Ishdeep Kaur, A. Shafiee, Alvaro Sanchez-Herrero, Phillip W. Janowicz, Akhilandeshwari Ravichandran, Christopher B. Howard, Anna Cifuentes‐Rius, J. McGovern, N. Voelcker, D. Hutmacher   +11 more
semanticscholar   +1 more source

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Journal of Biological Chemistry, 1985
Camptothecin, a cytotoxic drug, is a strong inhibitor of nucleic acid synthesis in mammalian cells and a potent inducer of strand breaks in chromosomal DNA.
Yaw-Huei Hsiangl, Robert Hertzbergj, Sidney Hechtj, Leroy F. LiuS   +3 more
semanticscholar   +1 more source

Formation of nanoparticles by cooperative inclusion between (S)-camptothecin-modified dextrans and β-cyclodextrin polymers

Beilstein Journal of Organic Chemistry, 2015
Novel (S)-camptothecin–dextran polymers were obtained by “click” grafting of azide-modified (S)-camptothecin and alkyne-modified dextrans. Two series based on 10 kDa and 70 kDa dextrans were prepared with a degree of substitution of (S)-camptothecin ...
Thorbjørn Terndrup Nielsen, Catherine Amiel, Laurent Duroux, Kim Lambertsen Larsen, Lars Wagner Städe, Reinhard Wimmer, Véronique Wintgens   +6 more
doaj   +1 more source

Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin is p53-independent

BMC Cell Biology, 2009
Background Deletion or mutation(s) of the survival motor neuron 1 (SMN1) gene causes spinal muscular atrophy (SMA). The SMN protein is known to play a role in RNA metabolism, neurite outgrowth, and cell survival.
Funanage Vicky L, Gómez-Curet Ilsa, Wu Chia-Yen, Scavina Mena, Wang Wenlan   +4 more
doaj   +1 more source