Results 21 to 30 of about 18,515 (223)
Safe approaches for camptothecin delivery: Structural analogues and nanomedicines
Journal of Controlled Release, 2017 Pablo Botella Asuncion
exaly +2 more sources
CFS-1686 causes cell cycle arrest at intra-S phase by interference of interaction of topoisomerase 1 with DNA. [PDF]
PLoS ONE, 2014 CFS-1686 (chemical name (E)-N-(2-(diethylamino)ethyl)-4-(2-(2-(5-nitrofuran-2-yl)vinyl)quinolin-4-ylamino)benzamide) inhibits cell proliferation and triggers late apoptosis in prostate cancer cell lines.
Ru-Wei Lin +11 more
doaj +1 more source
Microbiology Spectrum, 2023 Attenuating the expression of fungal camptothecin biosynthetic genes with subculturing is the challenge that halts their further implementation. The camptothecin productivity of the subcultured Aspergillus terreus has been restored upon addition of Ficus
Amgad M. Rady +9 more
doaj +1 more source
Nature Biomedical Engineering, 2020 Tumours with an immunosuppressive microenvironment respond poorly to therapy. Activation of the stimulator of interferon genes (STING) pathway can enhance intratumoural immune activation, but STING agonists are associated with high toxicity and degrade ...
Fei-Hu Wang +10 more
semanticscholar +1 more source
Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I. [PDF]
PLoS ONE, 2014 The CD44+ and CD44- subpopulations of the colorectal cancer cell line Caco2 were analyzed separately for their sensitivities to the antitumor drug camptothecin. CD44+ cells were less sensitive to camptothecin than CD44- cells.
Amit Roy +9 more
doaj +1 more source
Docking and QSAR Studies of Camptothecin Derivatives as Inhibitor of DNA Topoisomerase-I [PDF]
, 2011 Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme Topoisomerase-I (Topo-I) and has shown remarkable anticancer activity in preliminary clinical trials. The major limitation is its low solubility and high adverse reaction.
Feroz Khan +5 more
core +1 more source
Horticulture Research, 2021 The limited bioavailability of plant-derived natural products with anticancer activity poses major challenges to the pharmaceutical industry. An example of this is camptothecin, a monoterpene indole alkaloid with potent anticancer activity that is ...
Xiaolong Hao +9 more
semanticscholar +1 more source
Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila
BMC Biology, 2021 The anticancer drug camptothecin (CPT), first isolated from Camptotheca acuminata, was subsequently discovered in unrelated plants, including Ophiorrhiza pumila. Unlike known monoterpene indole alkaloids, CPT in C. acuminata is biosynthesized via the key
Mengquan Yang +8 more
semanticscholar +1 more source
A Practical Six-Step Synthesis of (S)-Camptothecin
, 2016 An asymmetric synthesis of (S)-camptothecin (1) has been accomplished in six steps starting from two commercially available ...
Daniel L. Comins (222088) +1 more
core +2 more sources
Advances on the camptothecin biosynthesis
上海师范大学学报. 自然科学版, 2018 Camptothecin is an indole alkaloid with anticancer activity extracted from woodyplant Camptotheca acuminata.The extremely low annual production of camptothecin makes it very expensive,so increasing the yield of camptothecin is an urgent problem to be ...
XU Ziyan +3 more
doaj +1 more source