Results 31 to 40 of about 42,673 (234)

Formation of nanoparticles by cooperative inclusion between (S)-camptothecin-modified dextrans and β-cyclodextrin polymers

Beilstein Journal of Organic Chemistry, 2015
Novel (S)-camptothecin–dextran polymers were obtained by “click” grafting of azide-modified (S)-camptothecin and alkyne-modified dextrans. Two series based on 10 kDa and 70 kDa dextrans were prepared with a degree of substitution of (S)-camptothecin ...
Thorbjørn Terndrup Nielsen, Catherine Amiel, Laurent Duroux, Kim Lambertsen Larsen, Lars Wagner Städe, Reinhard Wimmer, Véronique Wintgens   +6 more
doaj   +1 more source

Design and characterization of camptothecin gel for treatment of epidermoid carcinoma

Future Journal of Pharmaceutical Sciences, 2020
Background The objective of present research work is to design and characterize camptothecin gel using Carbopol-934 for the treatment of epidermoid carcinoma.
Sunil T. Galatage, Aditya S. Hebalkar, Raviraj V. Gote, Omkar R. Mali, Suresh G. Killedar, Durgacharan A. Bhagwat, Vijay M. Kumbhar   +6 more
doaj   +1 more source

Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin is p53-independent

BMC Cell Biology, 2009
Background Deletion or mutation(s) of the survival motor neuron 1 (SMN1) gene causes spinal muscular atrophy (SMA). The SMN protein is known to play a role in RNA metabolism, neurite outgrowth, and cell survival.
Funanage Vicky L, Gómez-Curet Ilsa, Wu Chia-Yen, Scavina Mena, Wang Wenlan   +4 more
doaj   +1 more source

Topoisomerase expression and amplification in solid tumours: Analysis of 24,262 patients. [PDF]

, 2017
BackgroundTopoisomerase I (TOPO1) and topoisomerase IIα (TOP2A) are specific targets of multiple chemotherapy drugs. Increased expression of TOPO1 protein and amplification of the TOP2A gene have been associated with treatment response in colorectal and ...
Arguello, David, Gatalica, Zoran, Heestand, Gregory M, Kurzrock, Razelle, Schwaederle, Maria   +4 more
core   +1 more source

Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells. [PDF]

, 2013
DNA-dependent protein kinase (DNA-PK) has an important role in the repair of DNA damage and regulates the radiation sensitivity of glioblastoma cells. The VCP (valosine-containing protein), a chaperone protein that regulates ubiquitin-dependent protein ...
Cao, L, Fei, X, Jiang, N, Kong, X, Larner, J, Mi, J, Qiu, Y, Shen, Y, Sheng, K, Sun, P   +9 more
core   +1 more source

Supplementary data for the quantum chemical calculation of free radical substitution reaction mechanism of camptothecin

Data in Brief, 2018
This data article contains the truncated view of the transition states for methyl radical attacking camptothecin at the site of 9, 10, 11, 12 and 14 in acidic conditions obtained from quantum computation of Gaussian 09 with B3LYP/6–31+G(d,p) level, also ...
Yujie Dai, Qingyuan Hua, Jun Ling, Chunfu Shao, Cheng Zhong, Xiuli Zhang, Yanying Hu, Liming Zhang, Yaotian Liu   +8 more
doaj   +1 more source

Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release [PDF]

, 2019
In the present work, we demonstrate the preparation of chitosan-based composites as vehicles of the natural occurring multi-drug resveratrol (RES). Such systems are endowed with potential therapeutic effects on inflammatory bowel diseases (IBD), such as ...
Benito Hernández, Elena María, Díaz Blanco, Manuel Jesús, Galbis Fuster, Elsa, Iglesias, N., Lucas Rodríguez, Ricardo, Paz Báñez, María Violante de   +5 more
core   +2 more sources

DNA Topoisomerase 1 Structure-BASED Design, Synthesis, Activity Evaluation and Molecular Simulations Study of New 7-Amide Camptothecin Derivatives Against Spodoptera frugiperda

Frontiers in Chemistry, 2018
Camptothecin and its derivatives (CPTs) have strong toxicity to eukaryotic cells by targeting their DNA topoisomerase 1 (Top1) protein and have been increasingly explored as potential pesticides for plant protection.
Zhiyan Jiang, Zhijun Zhang, Gaofeng Cui, Zhipeng Sun, Gaopeng Song, Yingqian Liu, Guohua Zhong   +6 more
doaj   +1 more source

The cytotoxicity of fatty acid/α-lactalbumin complexes depends on the amount and type of fatty acid [PDF]

, 2013
peer-reviewedComplexes of the milk protein, α-lactalbumin, and the fatty acid, oleic acid, have previously been shown to be cytotoxic. Complexes of α-lactalbumin and five different fatty acids (vaccenic, linoleic, palmitoleic, stearic, and elaidic acid ...
Aits, Andrade, Barbana, Brinkmann, Brinkmann, Budavari, Cury, de Lima, Düringer, Fischer, Gustafsson, Gustafsson, Hallgren, Kehoe, Knyazeva, Kohler, Lima, Liskova, Lišková, Mossberg, Mossberg, Mossberg, Nielsen, Permyakov, Permyakov, Pettersson, Pettersson-Kastberg, Rammer, Spolaore, Svanborg, Svensson, Svensson, Tolin, van Engeland, Vukojevic, Wilhelm   +35 more
core   +1 more source

Camptothecin Regulates Microglia Polarization and Exerts Neuroprotective Effects via Activating AKT/Nrf2/HO-1 and Inhibiting NF-κB Pathways In Vivo and In Vitro

Frontiers in Immunology, 2021
Microglia, the main immune cells in the brain, participate in the innate immune response in the central nervous system (CNS). Studies have shown that microglia can be polarized into pro-inflammatory M1 and anti-inflammatory M2 phenotypes.
Dewei He, Shoupeng Fu, Ang Zhou, Yingchun Su, Xiyu Gao, Yufei Zhang, Bingxu Huang, Jian Du, Dianfeng Liu   +8 more
doaj   +1 more source