Results 31 to 40 of about 18,515 (223)

Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition

Communications Biology, 2022
Non-camptothecin topoisomerase I inhibitor, Genz, shows potent activity against camptothecin-resistant cells through double-strand break induced cytotoxicity.
Masahiro Nishida, Takeshi Terabayashi, Shigeru Matsuoka, Tomoko Okuma, Sawako Adachi, Tadashi Tomo, Masanori Kawano, Kazuhiro Tanaka, Hiroshi Tsumura, Hirofumi Anai, Toshimasa Ishizaki, Yoshihiro Nishida, Katsuhiro Hanada   +12 more
doaj   +1 more source

Synthesis, Experimental and Density Functional Theory (DFT) Studies on Solubility of Camptothecin Derivatives

Molecules, 2018
Two camptothecin derivatives, 10-cyclohexyl-7-methyl-20(S)-camptothecin and 7-methyl-10-morpholino-20(S)-camptothecin, were synthesized and their differences in solubility were investigated using four chosen solvent systems.
Chin-Hung Lai, Chia-Chin Chang, Yi-Lin Weng, Ta-Hsien Chuang   +3 more
doaj   +1 more source

Targeted camptothecin delivery via silicon nanoparticles reduces breast cancer metastasis.

Biomaterials, 2020
In advanced breast cancer (BCa) patients, not the primary tumor, but the development of distant metastases, which occur mainly in the organ bone, and their adverse health effects are responsible for high mortality.
Marietta Landgraf, C. Lahr, Ishdeep Kaur, A. Shafiee, Alvaro Sanchez-Herrero, Phillip W. Janowicz, Akhilandeshwari Ravichandran, Christopher B. Howard, Anna Cifuentes‐Rius, J. McGovern, N. Voelcker, D. Hutmacher   +11 more
semanticscholar   +1 more source

Ophiorrhiza, a promising herbaceous source of the anticancer compound camptothecin [PDF]

, 2020
Camptothecin is an important source for the synthesis of some of the major anti-cancer agents such as irinotecan and topotecan. Traditional source of camptothecin are prominently woody plants such as Camptotheca acuminata Decne.
Krishnan, P N, Varghese, Sibi C, Gopinath, Geethu, Krishnakumar, G, Dintu, K P, Nair, Deepthi S, Satheeshkumar, K, Rameshkumar, K B   +7 more
core   +1 more source

Formation of nanoparticles by cooperative inclusion between (S)-camptothecin-modified dextrans and β-cyclodextrin polymers

Beilstein Journal of Organic Chemistry, 2015
Novel (S)-camptothecin–dextran polymers were obtained by “click” grafting of azide-modified (S)-camptothecin and alkyne-modified dextrans. Two series based on 10 kDa and 70 kDa dextrans were prepared with a degree of substitution of (S)-camptothecin ...
Thorbjørn Terndrup Nielsen, Catherine Amiel, Laurent Duroux, Kim Lambertsen Larsen, Lars Wagner Städe, Reinhard Wimmer, Véronique Wintgens   +6 more
doaj   +1 more source

Enhanced Stability and Bioactivity of Natural Anticancer Topoisomerase I Inhibitors through Cyclodextrin Complexation

Pharmaceutics, 2021
The use of cyclodextrins as drug nano-carrier systems for drug delivery is gaining importance in the pharmaceutical industry due to the interesting pharmacokinetic properties of the resulting inclusion complexes.
Víctor González-Ruiz, Ángel Cores, Olmo Martín-Cámara, Karen Orellana, Víctor Cervera-Carrascón, Patrycja Michalska, Ana I. Olives, Rafael León, M. Antonia Martín, J. Carlos Menéndez   +9 more
doaj   +1 more source

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Journal of Biological Chemistry, 1985
Camptothecin, a cytotoxic drug, is a strong inhibitor of nucleic acid synthesis in mammalian cells and a potent inducer of strand breaks in chromosomal DNA.
Y. Hsiang, R. Hertzberg, S. Hecht, Leroy-Fong Liu   +3 more
semanticscholar   +1 more source

Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin is p53-independent

BMC Cell Biology, 2009
Background Deletion or mutation(s) of the survival motor neuron 1 (SMN1) gene causes spinal muscular atrophy (SMA). The SMN protein is known to play a role in RNA metabolism, neurite outgrowth, and cell survival.
Funanage Vicky L, Gómez-Curet Ilsa, Wu Chia-Yen, Scavina Mena, Wang Wenlan   +4 more
doaj   +1 more source

Biotechnological approaches for the production of camptothecin

Applied Microbiology and Biotechnology
Camptothecin (CPT), an indole alkaloid popular for its anticancer property, is considered the third most promising drug after taxol and famous alkaloids from Vinca for the treatment of cancer in humans.
Akshatha Banadka, Sudheer Wudali Narasimha, V. S. Dandin, P. M. Naik, Amaranatha Vennapusa, Kalpalatha Melmaiee, Ramu S. Vemanna, J. M. Al-Khayri, Muthu Thiruvengadam, Praveen Nagella   +9 more
semanticscholar   +1 more source

Mitochondria-Targeted Delivery of Camptothecin Based on HPMA Copolymer for Metastasis Suppression

Pharmaceutics, 2022
Poor anti-metastasis effects and side-effects remain a challenge for the clinical application of camptothecin (CPT). Mitochondria can be a promising target for the treatment of metastatic tumors due to their vital roles in providing energy supply ...
Xiaoli Yi, Yue Yan, Xinran Shen, Lian Li, Yuan Huang   +4 more
doaj   +1 more source