Results 31 to 40 of about 39,854 (281)

Mitochondria-Targeted Delivery of Camptothecin Based on HPMA Copolymer for Metastasis Suppression

Pharmaceutics, 2022
Poor anti-metastasis effects and side-effects remain a challenge for the clinical application of camptothecin (CPT). Mitochondria can be a promising target for the treatment of metastatic tumors due to their vital roles in providing energy supply ...
Xiaoli Yi, Yue Yan, Xinran Shen, Lian Li, Yuan Huang   +4 more
doaj   +1 more source

Antiviral Action of Camptothecin [PDF]

Antimicrobial Agents and Chemotherapy, 1972
At a concentration of 10 μ m , camptothecin inhibited vaccinia deoxyribonucleic acid (DNA) synthesis in HeLa cells. Inhibition of viral DNA synthesis was observed when the drug was added before infection or at 1 or 2 hr after infection.
S B, Horwitz, C K, Chang, A P, Grollman
openaire   +2 more sources

Camptothecin Delivery via Tumor-Derived Exosome for Radiosensitization by Cell Cycle Regulation on Patient-Derived Xenograft Mice

Frontiers in Bioengineering and Biotechnology, 2022
Purpose: While radiotherapy remains the leading clinical treatment for many tumors, its efficacy can be significantly hampered by the insensitivity of cells in the S phase of the cell cycle to such irradiation.Methods: Here, we designed a highly targeted
Yiling Yang, Shiqi Ren, Wenpeng Huang, Jiahan Dong, Jiancheng Guo, Jie Zhao, Yonggao Zhang   +6 more
doaj   +1 more source

Biotechnological approaches for the production of camptothecin

Applied Microbiology and Biotechnology
Camptothecin (CPT), an indole alkaloid popular for its anticancer property, is considered the third most promising drug after taxol and famous alkaloids from Vinca for the treatment of cancer in humans.
Akshatha Banadka, Sudheer Wudali Narasimha, V. S. Dandin, P. M. Naik, A. Vennapusa, Kalpalatha Melmaiee, Ramu S. Vemanna, J. M. Al-Khayri, Muthu Thiruvengadam, Praveen Nagella   +9 more
semanticscholar   +1 more source

Docking and QSAR Studies of Camptothecin Derivatives as Inhibitor of DNA Topoisomerase-I

, 2011
Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme Topoisomerase-I (Topo-I) and has shown remarkable anticancer activity in preliminary clinical trials. The major limitation is its low solubility and high adverse reaction.
Feroz Khan, Feroz Khan, Santosh Srivastava, Dharmendra K. Yadav, Santosh K. Srivastava, Dharmendra Yadav   +5 more
core   +1 more source

Supplementary data for the quantum chemical calculation of free radical substitution reaction mechanism of camptothecin

Data in Brief, 2018
This data article contains the truncated view of the transition states for methyl radical attacking camptothecin at the site of 9, 10, 11, 12 and 14 in acidic conditions obtained from quantum computation of Gaussian 09 with B3LYP/6–31+G(d,p) level, also ...
Yujie Dai, Qingyuan Hua, Jun Ling, Chunfu Shao, Cheng Zhong, Xiuli Zhang, Yanying Hu, Liming Zhang, Yaotian Liu   +8 more
doaj   +1 more source

The role of single strand break repair pathways in cellular responses to camptothecin induced DNA damage.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020
Efficient DNA repair is critical for cell survival following exposure to DNA topoisomerase I (Top1) inhibitors camptothecin, a nature product from which the common chemotherapeutic drugs irinotecan and topotecan are derived.
Chao Mei, L. Lei, Li-Ming Tan, Xiao-jing Xu, Bai‐mei He, Chao Luo, Jiye Yin, Xi Li, Wei Zhang, Honghao Zhou, Zhaoqian Liu   +10 more
semanticscholar   +1 more source

DNA Topoisomerase 1 Structure-BASED Design, Synthesis, Activity Evaluation and Molecular Simulations Study of New 7-Amide Camptothecin Derivatives Against Spodoptera frugiperda

Frontiers in Chemistry, 2018
Camptothecin and its derivatives (CPTs) have strong toxicity to eukaryotic cells by targeting their DNA topoisomerase 1 (Top1) protein and have been increasingly explored as potential pesticides for plant protection.
Zhiyan Jiang, Zhijun Zhang, Gaofeng Cui, Zhipeng Sun, Gaopeng Song, Yingqian Liu, Guohua Zhong   +6 more
doaj   +1 more source

Synthesis and in Vivo Antitumor Activity of Poly(l-glutamic acid) Conjugates of 20(S)-Camptothecin

, 2016
Poly-α-(l-glutamic acid) (PG) conjugates of 20(S)-camptothecin (1, CPT) displayed improved aqueous solubility compared to CPT, were stable in aqueous solution at neutral pH, and were potent antitumor agents in vivo. Evaluation of PG molecular weight, CPT
Peter Klein (463828), Brian Baker (2361553), Jack W. Singer (3014436), John Tulinsky (3014442), Peter de Vries (3014430), Rama Bhatt (3014433), Garland Bellamy (3014439)   +6 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source