Results 51 to 60 of about 42,673 (234)
Molecules, 2023 The antitumor drug topotecan (TPT) is a potent inhibitor of topoisomerase I, triggering DNA breaks lethal for proliferating cancer cells. The mechanism is common to camptothecins SN38 (the active metabolite of irinotecan) and belotecan (BLT).
Christian Bailly, Gérard Vergoten
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Antiviral Action of Camptothecin [PDF]
Antimicrobial Agents and Chemotherapy, 1972 At a concentration of 10 μ m , camptothecin inhibited vaccinia deoxyribonucleic acid (DNA) synthesis in HeLa cells. Inhibition of viral DNA synthesis was observed when the drug was added before infection or at 1 or 2 hr after infection.
S B, Horwitz, C K, Chang, A P, Grollman
openaire +2 more sources
Dynamics of living cells in a cytomorphological state space. [PDF]
, 2019 Cells are nonequilibrium systems that exchange matter and energy with the environment to sustain their metabolic needs. The nonequilibrium nature of this system presents considerable challenges to developing a general theory describing its behavior ...
Chang, Amy Y, Marshall, Wallace F
core
Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers
Advanced Science, EarlyView.This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu +9 more
wiley +1 more source
Frontiers in Oncology, 2021 Higher oxidant stress capacity could promote invasion and metastasis. A previous study showed hepatocellular carcinoma (HCC) expressed more Nrf2 than para-carcinoma tissue.
Qian Liu +11 more
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DFT studies of camptothecins cytotoxicity III: camptothecin, irinotecan and SN-38
Acta Chimica Slovaca, 2022 AbstractGeometries of camptothecin, irinotecan, SN-38, and of their hypothetical Cu(II) complexes were optimized at the B3LYP/6-311G* level of theory. Their electron structure, evaluated in terms of Mulliken population analysis and Quantum Theory of Atoms-in-Molecule, was subsequently related toin vitrocytotoxicity.
Marek Štekláč, Martin Breza
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TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1 [PDF]
, 2012 The abortive activity of topoisomerases can result in clastogenic and/or lethal DNA damage in which the topoisomerase is covalently linked to the 3'- or 5'-terminus of a DNA strand break. This type of DNA damage is implicated in chromosome translocations
Abhishek Sharma +36 more
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Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles
Advanced NanoBiomed Research, EarlyView.This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
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Cell Reports, 2016 During transcription and DNA replication, the DNA template is overwound ahead of RNA and DNA polymerases and relaxed by DNA topoisomerases. Inhibitors of topoisomerases are potent anti-cancer agents.
Cyril Ribeyre +6 more
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BMEMat, EarlyView.Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu +13 more
wiley +1 more source