Results 61 to 70 of about 18,515 (223)
Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy
Phytotherapy Research, EarlyView.This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi +9 more
wiley +1 more source
Poly(amidoamine) Dendrimer/Camptothecin Complex: From Synthesis to In Vitro Cancer Cell Line Studies
Molecules, 2023 Camptothecin (CPT), an alkaloid with potent anticancer activity, is still not used in clinical practice due to its high hydrophobicity, toxicity, and poor active-form stability.
Ewa Oledzka +7 more
doaj +1 more source
White light emitting molecular logic gates
Smart Molecules, EarlyView.White light emitting smart molecules with Boolean logic computing ability are surveyed. Abstract White light emitting (WLE) materials are of considerable interest with commercial and societal applications in video displays and lighting devices. A characteristic property of WLE materials is the luminescence profile spanning from 380 to 700 nm.
Davide Benedetto Tiz +2 more
wiley +1 more source
A theoretical study on camptothecin–AM1 treatment
, 2001 Camptothecin (irinotecan), a new cytotoxic agent having antitumor activity and especially used in the treatment of advanced colorectal cancers is considered for AM1-RBF type semiempirical quantum chemical treatment together with some analogs of ...
Lemi Türker +2 more
core +1 more source
Cell Reports, 2016 During transcription and DNA replication, the DNA template is overwound ahead of RNA and DNA polymerases and relaxed by DNA topoisomerases. Inhibitors of topoisomerases are potent anti-cancer agents.
Cyril Ribeyre +6 more
doaj +1 more source
Smart Molecules, EarlyView.A novel chemosensing platform based on a molecular rotor architecture is established for specific, dynamic detection of lysosomal viscosity. The platform allows real‐time tracking of lysosomal viscosity fluctuations induced by various chemotherapeutic agents, highlighting its significant potential as a powerful tool for early cancer diagnostics and ...
Haoyang Song +6 more
wiley +1 more source
Regioselective synthesis of camptothecin
, 1994 A convergent synthesis of (±)camptothecin is ...
AV Rama Rao +5 more
core +1 more source
Research progress in structural modification of Camptothecins
生物医学转化Camptothecin and its derivatives are alkaloids with broad-spectrum anti-tumor activities and have significant inhibitory effect on malignant tumors. Its derivatives such as irinotecan and topotecan have been on market over 20 years.
Sun Shulei +3 more
doaj +1 more source
Molecules, 2023 The antitumor drug topotecan (TPT) is a potent inhibitor of topoisomerase I, triggering DNA breaks lethal for proliferating cancer cells. The mechanism is common to camptothecins SN38 (the active metabolite of irinotecan) and belotecan (BLT).
Christian Bailly, Gérard Vergoten
doaj +1 more source
Smart Molecules, EarlyView.Nonthermal ultrasound transforms acoustic energy into diverse therapeutic bioeffects through cavitation, mechanical stimulation, and physicochemical activation. This review discusses how acoustic parameters, biological mechanisms, and responsive materials interact to influence nonthermal ultrasound‐enabled cancer therapies. Mechanism‐guided engineering
Liu Wang +5 more
wiley +1 more source