Results 61 to 70 of about 39,854 (281)

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

A theoretical study on camptothecin–AM1 treatment

, 2001
Camptothecin (irinotecan), a new cytotoxic agent having antitumor activity and especially used in the treatment of advanced colorectal cancers is considered for AM1-RBF type semiempirical quantum chemical treatment together with some analogs of ...
Lemi Türker, Türker, Burhan Lemi, Turker, L   +2 more
core   +1 more source

Research progress in structural modification of Camptothecins

生物医学转化
Camptothecin and its derivatives are alkaloids with broad-spectrum anti-tumor activities and have significant inhibitory effect on malignant tumors. Its derivatives such as irinotecan and topotecan have been on market over 20 years.
Sun Shulei, Liu Xinxin, Hu Zhiwei, Wang Ziming   +3 more
doaj   +1 more source

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Distribution of camptothecin biosynthetic intermediates and identification the rate-limiting step of camptothecin biosynthesis

, 2019
Two key biosynthetic intermediates (pumiloside and strictosamide) of camptothecin were isolated. A high performance liquid chromatography-ultraviolet (HPLC-UV) method was developed to determine four main alkaloid compounds (pumiloside, strictosamide ...
Ning Zhang (23771), Jianli Liu (1529092), Yahui Wei (797524), Cuiling Wang (359625), Yanni Sun (27928)   +4 more
core   +1 more source

Droplet microfluidics: Enabling the tailored fabrication of hydrogel particles

Droplet, EarlyView.
Droplet microfluidics enables precise, versatile fabrication of hydrogel particles with controlled size, composition, and structure. This review summarizes fundamental principles, engineering strategies, and emerging applications, providing a framework for advancing microfluidic hydrogel technologies.
Zhongqiao Gan, Xu Hou
wiley   +1 more source

Preparation and characterization of multimodal hybrid organic and inorganic nanocrystals of camptothecin and gold

Acta Pharmaceutica Sinica B, 2019
We demonstrate a novel inorganic-organic crystalline nanoconstruct, where gold atoms were imbedded in the crystal lattices as defects of camptothecin nanocrystals, suggesting its potential use as simultaneous agents for cancer therapy and bioimaging. The
Christin P. Hollis, Alan K. Dozier, Barbara L. Knutson, Tonglei Li   +3 more
doaj   +1 more source

Discovering and harnessing camptothecin hydroxylase enzymes in Camptotheca acuminata for chemoenzymatic synthesis of anticancer camptothecin derivatives

, 2021
Since the 1990s, topotecan and irinotecan, two camptothecin derivatives, have been widely used as anticancer drugs owing to their phenomenal topoisomerase-I inhibitory activity.
Nguyen, Minh Tuan Anh
core  

Ultrasound Triggered Conversion of Porphyrin/Camptothecin-Fluoroxyuridine Triad Microbubbles into Nanoparticles Overcomes Multidrug Resistance in Colorectal Cancer.

ACS Nano, 2018
Multidrug resistance remains one of the main obstacles to efficient chemotherapy of colorectal cancer. Herein, an efficient combination therapeutic strategy is proposed based on porphyrin/camptothecin-floxuridine triad microbubbles (PCF-MBs) with high ...
Min Chen, X. Liang, Chuang Gao, Ranran Zhao, Nisi Zhang, Shumin Wang, Wen Chen, Bo Zhao, Jinrui Wang, Z. Dai   +9 more
semanticscholar   +1 more source

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

Macromolecular Rapid Communications, EarlyView.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source