Results 41 to 50 of about 42,673 (234)

PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks [PDF]

, 2020
Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the genome. Here, we identify histone lysine demethylase PHF2 as a novel regulator of the DNA damage response by regulating DNA damage ...
Alonso de la Vega, Ignacio, Attikum, Haico van, Checa Rodríguez, Cintia, Freire, Raimundo, Hernández Fernaud, Juan Ramón, Huertas, Pablo, Paz Cabrera, María Cristina, Rother, Magdalena B, Smits, Veronique A J, Wiegant, Wouter W   +9 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Camptothecin-Loaded Liposomes with α-Melanocyte-Stimulating Hormone Enhance Cytotoxicity Toward and Cellular Uptake by Melanomas: An Application of Nanomedicine on Natural Product

Journal of Traditional and Complementary Medicine, 2013
In this study, we attempted to develop functional liposomes loaded with camptothecin and attached to α-melanocyte-stimulating hormone (α-MSH) to target melanoma cells.
Chih-Hung Lin, Saleh A. Al-Suwayeh, Chih-Feng Hung, Chih-Chieh Chen, Jia-You Fang   +4 more
doaj   +1 more source

Injectable hyaluronic acid hydrogels encapsulating drug nanocrystals for long‐term treatment of inflammatory arthritis

Bioengineering & Translational Medicine, 2022
Antiproliferative chemotherapeutic agents offer a potential effective treatment for inflammatory arthritis. However, their clinical application is limited by high systemic toxicity, low joint bioavailability as well as formulation challenges.
Yongsheng Gao, Douglas Vogus, Zongmin Zhao, Wei He, Vinu Krishnan, Jayoung Kim, Yujie Shi, Apoorva Sarode, Anvay Ukidve, Samir Mitragotri   +9 more
doaj   +1 more source

Poly(amidoamine) Dendrimer/Camptothecin Complex: From Synthesis to In Vitro Cancer Cell Line Studies

Molecules, 2023
Camptothecin (CPT), an alkaloid with potent anticancer activity, is still not used in clinical practice due to its high hydrophobicity, toxicity, and poor active-form stability.
Ewa Oledzka, Klaudia Paśnik, Izabela Domańska, Monika Zielińska-Pisklak, Urszula Piotrowska, Marcin Sobczak, Łukasz Szeleszczuk, Anna Laskowska   +7 more
doaj   +1 more source

Mechanism-based model characterizing bidirectional interaction between PEGylated liposomal CKD-602 (S-CKD602) and monocytes in cancer patients [PDF]

, 2012
S-CKD602 is a PEGylated liposomal formulation of CKD-602, a potent topoisomerase I inhibitor. The objective of this study was to characterize the bidirectional pharmacokinetic-pharmacodynamic (PK-PD) interaction between S-CKD602 and monocytes.
Bang YJ, Belani CP, DM, Edwards RP, Friedl, Maruca LJ, Ramalingam S, Ramanathan RK, Stoller RG, Strychor S, Wu H, Zamboni BA, Zamboni WC   +12 more
core   +2 more sources

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Distinct requirements for the Rad32(Mre¹¹) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA [PDF]

, 2009
For a cancer cell to resist treatment with drugs that trap topoisomerases covalently on the DNA, the topoisomerase must be removed. In this study, we provide evidence that the Schizosaccharomyces pombe Rad32Mre11 nuclease activity is involved in the ...
Akamatsu, Antony M. Carr, Baldwin, Champoux, Connelly, Connelly, Edgar Hartsuiker, El-Khamisy, Farah, Gutz, Hartsuiker, Hopfner, Hopfner, Keeney, Keeney, Krogh, Krogh, Lengsfeld, Limbo, Liu, Malik, Matthew J. Neale, McKee, Miyoshi, Moreau, Neale, Nitiss, Osheroff, Porter, Pouliot, Prinz, Sartori, Shaw, Stracker, Subramanian, Takashima, Tomita, Utsugi, Young   +38 more
core   +2 more sources

Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics

Advanced Science, EarlyView.
 . ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao, Bingyao Bai, Xingqian Ye, Yiliang Lin   +3 more
wiley   +1 more source