Results 41 to 50 of about 39,854 (281)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Addition of Ester Enolates to N-Alkyl-2-fluoropyridinium Salts:  Total Synthesis of (±)-20-Deoxycamptothecin and (+)-Camptothecin

, 2016
Several 4-substituted dihydropyridones or 2-pyridones have been prepared by nucleophilic addition of α-(methylsulfanyl)ester enolates to N-alkyl-2-fluoropyridinium salts, followed by acid hydrolysis or oxidation with concomitant hydrolysis, of the ...
M.-Lluïsa Bennasar (2489200), Ester Zulaica (1407790), Cecília Juan (3033360), Yolanda Alonso (3033357), Joan Bosch (129788)   +4 more
core   +1 more source

Camptothecin Regulates Microglia Polarization and Exerts Neuroprotective Effects via Activating AKT/Nrf2/HO-1 and Inhibiting NF-κB Pathways In Vivo and In Vitro

Frontiers in Immunology, 2021
Microglia, the main immune cells in the brain, participate in the innate immune response in the central nervous system (CNS). Studies have shown that microglia can be polarized into pro-inflammatory M1 and anti-inflammatory M2 phenotypes.
Dewei He, Shoupeng Fu, Ang Zhou, Yingchun Su, Xiyu Gao, Yufei Zhang, Bingxu Huang, Jian Du, Dianfeng Liu   +8 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Camptothecin-Loaded Liposomes with α-Melanocyte-Stimulating Hormone Enhance Cytotoxicity Toward and Cellular Uptake by Melanomas: An Application of Nanomedicine on Natural Product

Journal of Traditional and Complementary Medicine, 2013
In this study, we attempted to develop functional liposomes loaded with camptothecin and attached to α-melanocyte-stimulating hormone (α-MSH) to target melanoma cells.
Chih-Hung Lin, Saleh A. Al-Suwayeh, Chih-Feng Hung, Chih-Chieh Chen, Jia-You Fang   +4 more
doaj   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Total Synthesis of Camptothecin

, 2008
Das pentacyclische Alkaloid Camptothecin besitzt eine ausgeprägte Zytotoxizität. Im Rahmen von Struktur-Wirkungs-Untersuchungen konnten als Analoga von Camptothecin die Verbindungen Irinotecan (Camptosar®) und ...
Liu, Deshan
core   +1 more source

Ophiorrhiza, a promising herbaceous source of the anticancer compound camptothecin

, 2020
Camptothecin is an important source for the synthesis of some of the major anti-cancer agents such as irinotecan and topotecan. Traditional source of camptothecin are prominently woody plants such as Camptotheca acuminata Decne.
Krishnan, P N, Varghese, Sibi C, Gopinath, Geethu, Krishnakumar, G, Dintu, K P, Nair, Deepthi S, Satheeshkumar, K, Rameshkumar, K B   +7 more
core   +1 more source

Injectable hyaluronic acid hydrogels encapsulating drug nanocrystals for long‐term treatment of inflammatory arthritis

Bioengineering & Translational Medicine, 2022
Antiproliferative chemotherapeutic agents offer a potential effective treatment for inflammatory arthritis. However, their clinical application is limited by high systemic toxicity, low joint bioavailability as well as formulation challenges.
Yongsheng Gao, Douglas Vogus, Zongmin Zhao, Wei He, Vinu Krishnan, Jayoung Kim, Yujie Shi, Apoorva Sarode, Anvay Ukidve, Samir Mitragotri   +9 more
doaj   +1 more source

Poly(amidoamine) Dendrimer/Camptothecin Complex: From Synthesis to In Vitro Cancer Cell Line Studies

Molecules, 2023
Camptothecin (CPT), an alkaloid with potent anticancer activity, is still not used in clinical practice due to its high hydrophobicity, toxicity, and poor active-form stability.
Ewa Oledzka, Klaudia Paśnik, Izabela Domańska, Monika Zielińska-Pisklak, Urszula Piotrowska, Marcin Sobczak, Łukasz Szeleszczuk, Anna Laskowska   +7 more
doaj   +1 more source