Results 81 to 90 of about 18,515 (223)

Generation of the Camptothecin Scaffold by a Flavin‐Catalyzed Photooxidative Skeletal Reorganization

Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.
The biosynthetic pathway of the anticancer drug precursor camptothecin involves an enigmatic skeletal reorganization from a 6/5/6 tetrahydro‐β‐carboline to a 6/6/5 pyrroloquinoline ring system. Here, we show that this transformation can be achieved by photooxidation with flavin cofactors, such as flavin mononucleotide (FMN) as catalysts.
Shenyu Liu, Zeliang Zhang, Benedikt Seligmann, Van Hung Bui, Tuan‐Anh Minh Nguyen, Thu‐Thuy T. Dang, Jakob Franke   +6 more
wiley   +2 more sources

Synthesis and Antitumor Activity of KFF Peptide-Drug Conjugates [PDF]

BIO Web of Conferences
In this article, to potentiate the antitumor efficacy of KFF, we designed a KFF-based peptide– drug conjugate. A KFF-camptothecin conjugate (KF-1) was synthesized via solid-phase synthesis, and its antitumor activity and mechanism were evaluated in HeLa ...
Xu Zi, Fang Changbo, Du Shanshan
doaj   +1 more source

Human APOBEC3G suppresses homologous recombination and LIG4‐independent end joining in DNA double‐strand break repair

The FEBS Journal, EarlyView.
Chromosomal DNA double‐strand breaks (DSBs) are repaired by homologous recombination and nonhomologous end joining (NHEJ). Recent work has additionally established theta‐mediated end‐joining (TMEJ) as a mechanism for DSB joining. Cells lacking NHEJ and TMEJ can repair DSBs in a homology‐dependent manner.
Shinta Saito, Miori Murayama, Usaki Arai, Sekifumi Akatsu, Ami Yamamoto, Misaki Kadoguchi, Noritaka Adachi   +6 more
wiley   +1 more source

The trimeric Shu complex in C. elegans is an ATPase that remodels RAD51 filaments in the homologous recombination‐associated DNA damage response

The FEBS Journal, EarlyView.
The C. elegans Shu complex (RFS‐1/RIP‐1/SWS‐1) is a DNA‐dependent ATPase that regulates RAD‐51 filaments during homologous recombination. The trimer preferentially binds 5′‐exposed DNA, remodels RAD‐51 filaments via ATP hydrolysis, and stabilizes filaments through ATP binding.
Sam Siu Hang Chu, Guangxin Xing, Kichang Paik, Anton Gartner, Hong Ling   +4 more
wiley   +1 more source

Avian Eggshell Evolutionary Adaptations Inform Biomimetic Strategies for Next‑Generation Precision Cancer Theranostics

Advanced Oncology, Volume 1, Issue 1, December 2026.
ABSTRACT The avian eggshell is a sophisticated, multi‐functional biocomposite and, more importantly, an autonomous life‐support system evolved to safeguard embryonic development across dynamic and hostile environments. Discussing eggshell‐inspired biomaterials beyond simple structural imitation, this review translates these evolutionary survival ...
Zhiqiang Liu, Sida Ling, Mengqi Zhao, Chunyan Zhu, Yaoye Zhou, Hengquan Hou, Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Zuyong Wang, Swee Hin Teoh   +11 more
wiley   +1 more source

Table_1_Antiviral and Virucidal Activities of Camptothecin on Fowl Adenovirus Serotype 4 by Blocking Virus Replication.docx

, 2022
Fowl adenovirus serotype 4 (FAdV-4) caused hepatitis–hydropericardium syndrome in poultry and caused huge economic losses to the poultry industry. At present, antiviral drugs have not been reported to be effective against this virus, and new treatment ...
Lei Yin (300551), Xiaomiao Hu (12414613), Xuehuai Shen (12414607), Xiaocheng Pan (5471537), Ruihong Zhao (414073), Kezong Qi (5010956), Danjun Zhang (12414616), Jieru Wang (179734), Yin Dai (12414610), Guijun Wang (1687741), Dongdong Yin (10914503), Hongyan Hou (482201)   +11 more
core   +1 more source

Ultrasound Triggered Conversion of Porphyrin/Camptothecin-Fluoroxyuridine Triad Microbubbles into Nanoparticles Overcomes Multidrug Resistance in Colorectal Cancer.

ACS Nano, 2018
Multidrug resistance remains one of the main obstacles to efficient chemotherapy of colorectal cancer. Herein, an efficient combination therapeutic strategy is proposed based on porphyrin/camptothecin-floxuridine triad microbubbles (PCF-MBs) with high ...
Min Chen, Xiao-Long Liang, Chuang Gao, Ran-Ran Zhao, Ni-Si Zhang, Shu-Min Wang, Wen Chen, Bo Zhao, Jin-Rui Wang, Z. Dai   +9 more
semanticscholar   +1 more source

The evolving role of immunotherapy in ovarian cancer

Cancer, Volume 132, Issue 18, 15 September 2026.
Abstract Ovarian cancer remains a major cause of gynecologic cancer mortality; and, although immune checkpoint inhibitors have transformed treatment in other solid tumors, their activity in ovarian cancer has been limited by tumor heterogeneity, an immunosuppressive tumor microenvironment, and the lack of robust predictive biomarkers.
Ana Carolina Veneziani, Laura Venegas, Amit M. Oza   +2 more
wiley   +1 more source

Preparação, caracterização e avaliação da eficácia terapêutica de microesferas de camptotecina preparadas a partir da poli-£-caprolactona [PDF]

, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia.A camptotecina é um fármaco que apresenta uma considerável atividade antitumoral cujo mecanismo de ação envolve a ...
Dora, Cristiana Lima
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, Volume 20, Issue 9, Page 2296-2322, September 2026.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source