Results 81 to 90 of about 39,854 (281)
Excited state tautomerization of camptothecin in aqueous solution
, 1996 The effect of pH on the absorption and fluorescence spectral characteristics of 20(S)-camptothecin was studied in aqueous solution. In alkaline solution, the lactone ring of camptothecin hydrolyzes to produce camptothecin carboxylate.
Isiah M. Warner +3 more
core +1 more source
Current Issues in Molecular BiologyBreast cancer is one of the leading causes of cancer-related mortality in women worldwide, highlighting the importance of effective therapies. This study evaluates the interaction between camptothecin, a potent anticancer agent, and two key receptors ...
Elmer Joel Millan-Casarrubias +5 more
doaj +1 more source
Pharmaceutics, 2020 The blood–brain barrier (BBB) hinders the brain delivery of many anticancer drugs. In pediatric patients, diffuse intrinsic pontine glioma (DIPG) represents the main cause of brain cancer mortality lacking effective drug therapy.
Catarina Chaves +8 more
doaj +1 more source
Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges
The Chemical Record, EarlyView.Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley +1 more source
Camptothecin paradoxically increases bioluminescence and luciferase expression.
, 2014 (A) Effects of camptothecin and 5-azacytidine on bioluminescence of MPC GL-9 cells compared to survival measured by Absorbance in XTT assay at 1 week. (B) corresponding immunoblot from the same experiment showing increased levels of firefly luciferase ...
Alessio Giubellino (283359) +5 more
core +1 more source
Camptothecin Induces PD-L1 and Immunomodulatory Cytokines in Colon Cancer Cells
Medicines, 2019 Background: Immunotherapy has changed the options for the treatment of various cancer types, but not colon cancer. Current checkpoint blockade approaches are ineffective in a large proportion of colon cancer cases, necessitating studies to elucidate its ...
Deepa Bedi +3 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Background and purpose Nano‐formulated chemotherapeutics prolong systemic availability of drugs and can reduce systemic toxicity, but their accumulation in solid tumours is often limited and unpredictable. Broadly applicable strategies to selectively enhance tumour delivery are lacking.
Annabel Kitowski +13 more
wiley +1 more source
PharmaceuticsCamptothecin-class compounds are anticancer active ingredients extracted from the Chinese unique medicinal plant, Camptotheca acuminata. They have been widely applied in the treatment of various cancers due to their high efficacy and broad-spectrum anti ...
Mingliang Su +8 more
doaj +1 more source
KU80 suppresses endonuclease G activity to preserve genomic integrity
The FEBS Journal, EarlyView.Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan +8 more
wiley +1 more source
Cytotoxic Effects of Fascaplysin against Small Cell Lung Cancer Cell Lines
Marine Drugs, 2014 Fascaplysin, the natural product of a marine sponge, exhibits anticancer activity against a broad range of tumor cells, presumably through interaction with DNA, and/or as a highly selective cyclin-dependent kinase 4 (CDK4) inhibitor.
Gerhard Hamilton
doaj +1 more source