Results 81 to 90 of about 23,580 (195)

Arabidopsis WSS1A, a DNA‐protein crosslink repair protease, delays leaf senescence in cooperation with SUMO3

The Plant Journal, Volume 127, Issue 4, August 2026.
SUMMARY Leaf senescence, the final stage of leaf development, is regulated by complex interplays of intrinsic genetic programs and environmental cues. Throughout their lifetimes, all living organisms encounter various endogenous and environmental challenges, many of which can cause potentially fatal DNA damage. Among these, DNA‐protein crosslinks (DPCs)
Sanghoon Park, Hyunwoo Oh, Ukcheol Jeong, Jae Ho Lee, Hyeyoung Choi, Hyunsu Park, Jinkwang Kim, Yongmin Kim, Junmin Kwak, Yeong Seon Yoon, Zhonghai Li, Jong‐Chan Lee, Hye Ryun Woo   +12 more
wiley   +1 more source

High-Precision Field- Effect Transistor Biosensor for Analyzing Differential Effects of Anti-Cancer Drugs on Cancerous and Non-Cancerous Cells

Biosensors
A high-precision biosensor technique is introduced, offering the capability to independently evaluate the effects of anti-cancer drugs on both cancerous (RAJI) and non-cancerous (WIL2S) cells.
Can Li, Can Hu, Ling Li, Feng He, Xiaofei Li   +4 more
doaj   +1 more source

The direct conversion of strictosamide to pumiloside <i>in planta</i> expands the camptothecin biosynthetic pathway. [PDF]

Synth Syst Biotechnol
Li Y, Wu Z, Chen J, Ruan Q, Yao L, Shao L, Hao X, Kai G.   +7 more
europepmc   +1 more source

Computational Screening of Microbial Metabolites as Erythropoietin (EPO) Mimetics for the Treatment of Anemia. [PDF]

Biomed Eng Comput Biol
Hasan MN, Shishir MA, Rahman KMM, Islam SBU, Shill MC, Bulbul N, Safa A, Jime JS, Fakruddin M.   +8 more
europepmc   +1 more source

Molecular Determinants of Response and Rational Drug Combinations for Antibody-Drug Conjugates (ADCs) with Topoisomerase I (TOP1) Inhibitor Payloads. [PDF]

J Mol Biol
Pommier Y.
europepmc   +1 more source

Generation of NBS1 knockout in Chinese hamster cells revealed ATR role for radiation and etoposide induced DNA damage in absence of NBS1 proteins. [PDF]

Front Oncol
Badakul G, Maeda J, Kato TA.
europepmc   +1 more source

DIMORPH: an integrated multi-omics resource for camptothecin-producing plants. [PDF]

Mol Hortic
Lou Q, Pu X, Xu W, Gao R, Gao L, Xu Z, Wang Z, Li X, Xin T, Li H, Wang W, Tang D, Xu A, Qi G, Gan Y, Zhang J, Song J.   +16 more
europepmc   +1 more source

In vitro analysis of the anticancer and antimicrobial potentials and phytochemical profiles of leaf extracts from five Vachellia species. [PDF]

Curr Res Toxicol
More GK, Kalu CM, Tchangoue YAN, Tekere M, Msagat TAM, Udeh EL.   +5 more
europepmc   +1 more source

Characterization of Alternaria alternata alternariol monomethyl ether with a potential antiproliferative activity by topoisomerases inhibition; molecular docking and dynamic simulations. [PDF]

Sci Rep
El-Sayed ASA, Aboelez MO, Ezelarab HAA, Ewedah TM, El-Baz AF, Ashraf R, Diab A, Safwat G, Rady AM, El-Mekkawy RM.   +9 more
europepmc   +1 more source

Camptothecin Nanowires Induce the cGAS-STING Pathway to Remold Tumor-Associated Macrophages for Antitumor Immunity. [PDF]

Pharmaceutics
Zhang C, Wu H, Chen X, Yin W, Huang S, Wen D, Song X, Xu X, Zhang C, Tai S.   +9 more
europepmc   +1 more source