Results 71 to 80 of about 39,854 (281)

Chromatin determinants impart camptothecin sensitivity

, 2017
Camptothecin-induced locking of topoisomerase 1 on DNA generates a physical barrier to replication fork progression and creates topological stress. By allowing replisome rotation, absence of the Tof1/Csm3 complex promotes the conversion of impending ...

core   +1 more source

Table_1_Antiviral and Virucidal Activities of Camptothecin on Fowl Adenovirus Serotype 4 by Blocking Virus Replication.docx

, 2022
Fowl adenovirus serotype 4 (FAdV-4) caused hepatitis–hydropericardium syndrome in poultry and caused huge economic losses to the poultry industry. At present, antiviral drugs have not been reported to be effective against this virus, and new treatment ...
Lei Yin (300551), Xiaomiao Hu (12414613), Xuehuai Shen (12414607), Xiaocheng Pan (5471537), Ruihong Zhao (414073), Kezong Qi (5010956), Danjun Zhang (12414616), Jieru Wang (179734), Yin Dai (12414610), Guijun Wang (1687741), Dongdong Yin (10914503), Hongyan Hou (482201)   +11 more
core   +1 more source

Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIP_L, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines

Molecular Cancer, 2009
Background An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with ...
Fossan Kjell O, Skavland Jørn, Wergeland Line, Hagland Hanne R, Dimba Elizabeth AO, Bredholt Therese, Tronstad Karl J, Johannessen Anne C, Vintermyr Olav K, Gjertsen Bjørn T   +9 more
doaj   +1 more source

Natural Products as Modulators of ABC Transporters in Breast Cancer

Phytotherapy Research, EarlyView.
ABSTRACT Breast cancer remains a significant global health challenge, with high incidence and mortality rates despite advancements in early detection and treatment. Multidrug resistance (MDR), particularly in aggressive subtypes like triple‐negative breast cancer (TNBC), continues to hinder effective therapy.
Yoganishalini Sagadevan, Reyhaneh Farghadani, Ammu K. Radhakrishnan   +2 more
wiley   +1 more source

Synthesis and Antitumor Activity of KFF Peptide-Drug Conjugates [PDF]

BIO Web of Conferences
In this article, to potentiate the antitumor efficacy of KFF, we designed a KFF-based peptide– drug conjugate. A KFF-camptothecin conjugate (KF-1) was synthesized via solid-phase synthesis, and its antitumor activity and mechanism were evaluated in HeLa ...
Xu Zi, Fang Changbo, Du Shanshan
doaj   +1 more source

A general and green approach of pH‐sensitive ZIF‐67 for encapsulating active substances

Smart Molecules, EarlyView.
Zeolitic imidazolate framework‐67 (ZIF‐67) was successfully synthesized in deionized water for 2 h in this work; meanwhile, various active substances could be encapsulated in one‐pot with the same process, resulting in high loading rates. The study delved into the growth mechanism, morphological difference and loading capacity.
Xinyi Sun, Yan Qi, Xinhao Che, Lulu Zhou, Yuxin Li, Lei Zhang, Jing Hu   +6 more
wiley   +1 more source

Design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug

Drug Delivery, 2021
A novel tumor-targeted glutathione responsive Glycosylated-Camptothecin nanosupramolecular prodrug (CPT-GL NSp) was designed and fabricated via a disulfide bond. The effects of glycoligand with different polarities on solubility, self-assembly, stability,
Wenhua Li, Zhong Chen, Xiaoying Liu, Mingming Lian, Haisheng Peng, Changmei Zhang   +5 more
doaj   +1 more source

White light emitting molecular logic gates

Smart Molecules, EarlyView.
White light emitting smart molecules with Boolean logic computing ability are surveyed. Abstract White light emitting (WLE) materials are of considerable interest with commercial and societal applications in video displays and lighting devices. A characteristic property of WLE materials is the luminescence profile spanning from 380 to 700 nm.
Davide Benedetto Tiz, Massimo Catania, David C. Magri   +2 more
wiley   +1 more source

Synthesis of (+)-camptothecin [PDF]

Arkivoc, 2005
A synthesis of optically pure camptothecin was achieved in 4 steps from previously reported aldehyde employing Sharpless asymmetric dihydroxylation as the key step.
Subhash P. Chavan, M. S. Venkatraman
openaire   +1 more source

A lysosome‐targeted ultra‐sensitive viscosity probe for monitoring viscosity alterations during chemotherapy

Smart Molecules, EarlyView.
A novel chemosensing platform based on a molecular rotor architecture is established for specific, dynamic detection of lysosomal viscosity. The platform allows real‐time tracking of lysosomal viscosity fluctuations induced by various chemotherapeutic agents, highlighting its significant potential as a powerful tool for early cancer diagnostics and ...
Haoyang Song, Hui Bian, Lei Liu, Gahyeon Park, Bingqing Sun, Qiongzheng Hu, Juyoung Yoon   +6 more
wiley   +1 more source