Results 91 to 100 of about 39,854 (281)

Transcription Factor OpWRKY3 Is Involved in the Development and Biosynthesis of Camptothecin and Its Precursors in Ophiorrhiza pumila Hairy Roots

International Journal of Molecular Sciences, 2019
The plant Ophiorrhiza pumila produces camptothecin (CPT), a kind of terpene indole alkaloid (TIAs) that has been widely used in treatment of cancer. Tryptophan-arginine-lysine-tyrosine (WRKY) transcription factors have been reported to play important ...
Can Wang, Chao Wu, Yao Wang, Chenhong Xie, M. Shi, S. Nile, Zhigang Zhou, G. Kai   +7 more
semanticscholar   +1 more source

Transcriptional Regulation of the Novel Theacrine Synthase Gene CsTcS2 by the CsTINY–CsWRKY33 Module Underpins Theacrine Biosynthesis in Camellia sinensis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Theacrine (1,3,7,9‐tetramethyluric acid) is a purine alkaloid detected in multiple wild and specialised tea germplasms (Camellia sinensis) from South China, including Kucha. However, the molecular mechanisms governing its biosynthesis remain poorly understood. Here, we identify CsTcS2 as a novel theacrine synthase in tea plant.
Ting Wu, Lihua Zhu, Chenyu Shao, Siyi Xie, Na Li, Xinyu Li, Fang Wang, Lvwen Peng, Huiying Jin, Fanghuizi Shang, Jianan Huang, Zhonghua Liu, Na Tian, Shuoqian Liu   +13 more
wiley   +1 more source

Camptothecin from Camptotheca acuminate hairy roots

, 2008
Camptothecin (CPT) is an important anticancer and antiviral alkaloid produced by the Chinese native tree Camptotheca acuminate (Nyssaceae) and other species belonging to the families Apocynaceae, Olacaceae, and Rubiaceae.
张卫, 岳向国
core  

Immunogenic camptothesome nanovesicles comprising sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy

Nature Nanotechnology, 2021
Zhiren Wang, Nicholas Little, Jiawei Chen, Kevin Tyler Lambesis, Kimberly T. Le, Weiguo Han, A. Scott, Jianqin Lu   +7 more
semanticscholar   +1 more source

Cell‐Specific Expression and Cellular Compartmental Regulation in Camptothecin Biosynthesis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant secondary metabolites such as monoterpenoid indole alkaloids (MIAs) show tightly regulated biosynthesis and accumulation in specific organelles of distinct cell types. However, the cell‐specific expression patterns of anticancer MIA camptothecin biosynthetic genes in Ophiorrhiza pumila and the regulatory mechanisms of camptothecin ...
Xiaolong Hao, Yinkai Yang, Tiantian Chen, Xiaoxuan Fan, Yiqing Peng, Qingyan Ruan, Qin Zhou, Fanghao Liu, Jiayi He, Yongpeng Li, Yue Feng, Jiyan Qi, Guoyin Kai   +12 more
wiley   +1 more source

Synthesis and Antiproliferative Activities of Conjugates of Paclitaxel and Camptothecin with a Cyclic Cell-Penetrating Peptide

Molecules, 2019
Cell-penetrating peptide [WR]5 has been previously shown to be an efficient molecular transporter for various hydrophilic and hydrophobic molecules. The peptide was synthesized using Fmoc/tBu solid-phase chemistry, and one arginine was replaced with one ...
Naglaa Salem El-Sayed, Amir Nasrolahi Shirazi, Muhammad Imran Sajid, Shang Eun Park, Keykavous Parang, Rakesh Kumar Tiwari   +5 more
doaj   +1 more source

Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates

ACS Medicinal Chemistry Letters, 2019
Antibody–drug conjugates (ADCs) that incorporate the exatecan derivative DXd in their payload are showing promising clinical results in solid tumor indications. The payload has an F-ring that also contains a second chiral center, both of which complicate
Wei Li, Karen H. Veale, Qifeng Qiu, K. Sinkevicius, E. K. Maloney, Juliet A. Costoplus, J. Lau, Helen Evans, Y. Setiady, O. Ab, Stephen M. Abbott, Jenny Lee, Somsinee Wisitpitthaya, Anna Skaletskaya, Lintao Wang, T. Keating, R. Chari, Wayne C. Widdison   +17 more
semanticscholar   +1 more source

RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation

Photochemistry and Photobiology, EarlyView.
UV radiation and other compounds generate DNA adducts that block transcription and induce cell death if not removed by the nucleotide excision repair system. In this work, we used a small‐scale pharmacological screen to discover that inhibition of the recombinase RAD51 sensitized nonreplicating quiescent keratinocytes to both UVR and other agents that ...
Saman Khan, Angitha Nair, M. Alexandra Carpenter, Michael G. Kemp   +3 more
wiley   +1 more source

Effect of camptothecin reversal on RNA synthesis.

, 2013
(A), Aggregate view of RNA synthesis of genes larger than 100 kb in normal human fibroblasts with the genes aligned by transcriptional start sites (TSS).
Benjamin Biewen (476021), Nathan Berg (476023), Artur Veloso (476020), Jayendra Prasad (29161), Brian Magnuson (476026), Karan Bedi (476025), Mats Ljungman (36206), Thomas E. Wilson (134623), Michelle T. Paulsen (476022), Leonardo Carmo de Andrade Lima (476024)   +9 more
core   +1 more source

Systemic anti‐cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy

International Journal of Cancer, Volume 159, Issue 2, Page 460-466, 15 July 2026.
What's new? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Cassie Higgins, Lynn R. Gauthier, Blair H. Smith, Lesley Colvin   +3 more
wiley   +1 more source