Results 91 to 100 of about 18,515 (223)

Advances in Camptothecin-Class Compounds Nanomedicines: A Comprehensive Review of Antitumor Strategies

Pharmaceutics
Camptothecin-class compounds are anticancer active ingredients extracted from the Chinese unique medicinal plant, Camptotheca acuminata. They have been widely applied in the treatment of various cancers due to their high efficacy and broad-spectrum anti ...
Mingliang Su, Zhiwei Liang, Long Chen, Taoyu Wang, Shabatula Aisika, Yanbin Peng, Yonghui Wu, Huahe Zhu, Lixin Wang   +8 more
doaj   +1 more source

Characterization of the Blood–Brain Barrier Integrity and the Brain Transport of SN-38 in an Orthotopic Xenograft Rat Model of Diffuse Intrinsic Pontine Glioma

Pharmaceutics, 2020
The blood–brain barrier (BBB) hinders the brain delivery of many anticancer drugs. In pediatric patients, diffuse intrinsic pontine glioma (DIPG) represents the main cause of brain cancer mortality lacking effective drug therapy.
Catarina Chaves, Xavier Declèves, Meryam Taghi, Marie-Claude Menet, Joelle Lacombe, Pascale Varlet, Nagore G. Olaciregui, Angel M. Carcaboso, Salvatore Cisternino   +8 more
doaj   +1 more source

Bio‐Inspired Biopolymeric Implantable Platform for Localized and Sustained Drug Delivery in Solid Tumor Treatment

Advanced Functional Materials, Volume 36, Issue 73, 10 September 2026.
A bio‐inspired biopolymeric implantable drug delivery platform enables localized and sustained release of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38) in solid tumor treatment. The three‐dimensional (3D) structured crosslinked‐chitosan implants are fabricated via 3D‐printed molds and provide drug release over 3 months, significantly inhibiting tumor growth ...
Mercedes Lozano‐Garcia, Constantine Vogiatzis, Alejandra Planells‐Devesa, Emre Dikici, Caroline Vieira Maluf, Vasudev Vivekanand Nayak, Paulo G. Coelho, Lukasz Witek, Alicia Bilbao, Daniel Bilbao, Prasoon Mohan, Sapna Deo, Sylvia Daunert   +12 more
wiley   +1 more source

Overcoming Photodynamic Therapy Resistance: GSH‐Responsive AIE Photosensitizer‐Hydroxycamptothecin Nanoliposomes for Extrahepatic Cholangiocarcinoma

Advanced Healthcare Materials, Volume 15, Issue 35, 18 September 2026.
A GSH‐responsive AIE nanoplatform (TSH NPs) with RGD‐mediated tumor targeting co‐delivers a photosensitizer (TPA) and HCPT for extrahepatic cholangiocarcinoma. The system synergistically enhances PDT and chemotherapy by suppressing HIF‐1α/VEGF‐driven hypoxic adaptation, effectively overcoming PDT resistance.
Yong Qu, Tao Peng, Yating Zhang, Juanmei Cao, Birong Wang, Chuxing Chai, Zhiyuan Gao, Yiting Xu, Yifan Jin, Yuqing Wang, Zhuoxia Li, Xu Liu, Tianqi Zhao, Yufan Chen, Weimin Lv, Di Lu, Changzheng Huang, Dan Ding, Jinxiang Zhang, Min Li   +19 more
wiley   +1 more source

Camptothecin from Camptotheca acuminate hairy roots

, 2008
Camptothecin (CPT) is an important anticancer and antiviral alkaloid produced by the Chinese native tree Camptotheca acuminate (Nyssaceae) and other species belonging to the families Apocynaceae, Olacaceae, and Rubiaceae.
张卫, 岳向国
core  

Camptothecin paradoxically increases bioluminescence and luciferase expression.

, 2014
(A) Effects of camptothecin and 5-azacytidine on bioluminescence of MPC GL-9 cells compared to survival measured by Absorbance in XTT assay at 1 week. (B) corresponding immunoblot from the same experiment showing increased levels of firefly luciferase ...
Alessio Giubellino (283359), Karel Pacak, G. Gary. Sahagian (587314), James F. Powers (587311), Arthur S. Tischler (147121), Parimal G. Korgaonkar (587312), Stephanie Fliedner (587313)   +5 more
core   +1 more source

Camptothecin Induces PD-L1 and Immunomodulatory Cytokines in Colon Cancer Cells

Medicines, 2019
Background: Immunotherapy has changed the options for the treatment of various cancer types, but not colon cancer. Current checkpoint blockade approaches are ineffective in a large proportion of colon cancer cases, necessitating studies to elucidate its ...
Deepa Bedi, Henry J. Henderson, Upender Manne, Temesgen Samuel   +3 more
doaj   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, Volume 13, Issue 49, 3 September 2026.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Avaliação do potencial de utilização de nanocápsulas poliméricas na melhoria da resposta antimetastática de um alcalóide citotóxico, a camptotecina [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde.
Neckel, Gecioni Loch
core  

Covalently crosslinked organophosphorous derivatives‐chitosan hydrogel as a drug delivery system for oral administration of camptothecin

European journal of pharmaceutics and biopharmaceutics, 2019
Graphical abstract Figure. No Caption available. ABSTRACT Hydrogels are widely studied as drug delivery system. In this work we propose the employment of tetrakis(hydroxymethyl)phosphonium chloride as crosslinking agent to obtain covalent hydrogels based
Mayte Martínez-Martínez, Guillermo Rodríguez-Berna, M. Bermejo, I. González-Álvarez, M. González-Álvarez, V. Merino   +5 more
semanticscholar   +1 more source