Results 111 to 120 of about 42,673 (234)

Biosynthetically‐Inspired Oxidative Cleavage Platform Enables Rapid Access to Diverse and Architecturally Complex Chemotypes From Indole Alkaloids

ChemistryEurope, Volume 4, Issue 4, April 2026.
We report a biosynthesis‐inspired ring distortion approach that involves oxidative ring cleavage, ring rearrangement, and ring expansion reactions from a diverse collection of indole alkaloids and derivatives. This chemical synthesis approach led to the synthesis of >25 distinct chemotypes from 14 indole alkaloids.
Derek A. Leas, Eli S. Levit, Alexis A. Bragg, Taylor A. Gerrein, Khalil A. Abboud, Pingrong Wei, Lukasz M. Dobrzycki, Robert W. Huigens III   +7 more
wiley   +1 more source

In Silico Study of Camptothecin-Based Pro-Drugs Binding to Human Carboxylesterase 2

Biomolecules
Pro-drugs, which ideally release their active compound only at the site of action, i.e., in a cancer cell, are a promising approach towards an increased specificity and hence reduced side effects in chemotherapy.
Frank Beierlein, Anselm H. C. Horn, Heinrich Sticht, Andriy Mokhir, Petra Imhof   +4 more
doaj   +1 more source

Novel insights into extracellular vesicles: An update on biomolecules, immunomodulation and clinical strategies in skin melanoma

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Extracellular vesicles mediate melanoma progression by transferring biomolecules (proteins, nucleic acids) that reshape the tumour microenvironment, promote immune evasion and drive metastasis. They also serve as diagnostic biomarkers and engineered therapeutic carriers for targeted therapy.
Junshu Li, Wencheng Zhou, Ying Cen, Yong Qing   +3 more
wiley   +1 more source

Nanoparticles in microdroplets: Recent advances in microfluidic generators for producing functional microbeads

Droplet, Volume 5, Issue 2, April 2026.
Functional hybrid microbeads with electrical, magnetic, and/or optical responsiveness have emerged as versatile platforms for biotechnology. This review highlights recent advances in microfluidic technologies for producing such microbeads, with a focus on incorporating functional nanoparticles in microdroplet systems.
  Bayinqiaoge, Chengchen Zhang, Shi‐Yang Tang   +2 more
wiley   +1 more source

Patent Disclosure and R&D Competition in Pharmaceuticals. [PDF]

The prominent role played by patents within the pharmaceutical domain is unquestionable. In this paper we take an unusual perspective and focus on a relatively neglected implication of patents: the effect of patent-induced information disclosure (of both
Fabio Pammolli, Laura Magazzini, Maria Alessandra Rossi, Massimo Riccaboni   +3 more
core   +3 more sources

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B

Scientific Reports
Temperature is a vital environmental factor affecting organisms’ survival as they determine the mechanisms to tolerate rapid temperature changes. We demonstrate an experimental system for screening chemicals that affect cold tolerance in Caenorhabditis ...
Misaki Okahata, Natsumi Sawada, Kenji Nakao, Akane Ohta, Atsushi Kuhara   +4 more
doaj   +1 more source

Tumor Organoid and Microenvironment Cocultures: Implications for Basic and Translational Cancer Research

MedComm, Volume 7, Issue 4, April 2026.
Organoid technology has attracted significant attention in cancer research. By incorporating tumor organoids with elements of the tumor microenvironment in coculture systems, researchers have gained powerful new tools to unravel the complex interplay that influences tumor progression and therapeutic outcomes.
Jiajun Yang, Chunliang Cheng, Wenqin Luo, Xingfeng He, Yaqi Li, Xiang Hu, Sanjun Cai, Hai Zou, Shaobo Mo, Junjie Peng   +9 more
wiley   +1 more source

Research advances in the applications of mitochondria‐targeted cyanine dyes in imaging

VIEW, Volume 7, Issue 2, April 2026.
Near‐infrared (NIR) fluorescence imaging, a novel non‐invasive diagnostic tool, plays a crucial role in the imaging and monitoring of solid tumors. At its core are NIR fluorescent dyes, which are widely utilized due to their ability to minimize tissue autofluorescence interference, thereby significantly enhancing the signal‐to‐noise ratio (SNR) and ...
Hongye Liao, Jingyu Deng, Qin Li, Tong Xia, Xun Yang, Simei Yang, Changzhen Sun, Xia Xiong, Li Liu   +8 more
wiley   +1 more source

IAP Antagonists Selectively Eliminate Therapy‐Induced Senescent Cancer Cells via TNFα‐Independent Apoptosis

Cancer Science, Volume 117, Issue 4, Page 1043-1056, April 2026.
Upon chemotherapy, a subset of cancer cells enters a senescent state, referred to as TIS. When IAP antagonists are administered, TIS cells are selectively eliminated through TNFα‐independent apoptosis. TNFα secreted by TIS cancer cells may also act in a paracrine manner to enhance extrinsic apoptosis in neighboring non‐senescent cancer cells.
Hiroaki Ochiiwa, Takeshi Wakasa, Yuki Kataoka, Koji Ando, Eiji Oki, Yoshihiko Maehara, Makoto Iimori, Hiroyuki Kitao   +7 more
wiley   +1 more source