Results 121 to 130 of about 39,854 (281)
Biochemical Pharmacology, 2017 Graphical abstract Figure. No Caption available. ABSTRACT Small cell lung cancer (SCLC) is characterized by excellent initial response to chemotherapy and radiation therapy with a majority of the patients showing tumor shrinkage and even remission ...
J. Friedman +12 more
semanticscholar +1 more source
Pathway enrichment for genes following camptothecin treatment and reversal.
, 2013 (A) Pathways represented by genes up-regulated at least 2-fold, and (B) down-regulated at least 2-fold following camptothecin treatment and recovery. Human fibroblasts were treated with 20 µM camptothecin for 45 minutes and incubated for the last 15 min ...
Benjamin Biewen (476021) +9 more
core +1 more source
Scientific ReportsTemperature is a vital environmental factor affecting organisms’ survival as they determine the mechanisms to tolerate rapid temperature changes. We demonstrate an experimental system for screening chemicals that affect cold tolerance in Caenorhabditis ...
Misaki Okahata +4 more
doaj +1 more source
Stimuli‐Responsive Poly(Disulfide)s: A Versatile Platform for Intelligent Drug Delivery Systems
MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.Ring‐opening polymerization based on dynamic disulfide bond exchange is an important method for synthesizing poly(disulfide)s. These polymers possess stimulus‐responsive mechanisms and show broad prospects in intelligent drug delivery. This review systematically discusses the ring‐opening polymerization strategy and research progress of drug delivery ...
Yuechen He +7 more
wiley +1 more source
Epigenetic Regulation in Cardiovascular Diseases: Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 6, June 2026.Environmental and lifestyle exposures reshape the cardiovascular epigenome through coordinated regulation of DNA methylation, histone modifications, noncoding RNAs, and RNA methylation (m6A). These multilayered mechanisms drive enhancer‐centered regulatory network remodeling and epigenomic plasticity in cardiovascular diseases, highlighting emerging ...
Wangzheqi Zhang +7 more
wiley +1 more source
MAPK signaling is involved in camptothecin-induced cell death
, 2002 Camptothecin, a topoisomerase I inhibitor, is a well-known anticancer drug. However, its mechanism has not been well studied in human gastric cancer cell lines. Camptothecin induced apoptotic cell death in human gastric cancer cell line AGS.
Lee, Yun-Sil +9 more
core
Avaliação do potencial de utilização de nanocápsulas poliméricas na melhoria da resposta antimetastática de um alcalóide citotóxico, a camptotecina [PDF]
, 2006 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde.
Neckel, Gecioni Loch
core
Novel cytotoxic 7-iminomethylene and 7-aminomethyl derivatives of camptothecin
, 2001 A series of new 7-iminomethyl derivatives of camptothecin were obtained from camptothecin-7-aldehyde and aromatic, alicyclic and aliphatic amines. Their hydrogenation led to the corresponding amines.
N. Carenini +15 more
core +1 more source
Ribosomal Proteins in Cell Biology and Cancer
MedComm – Oncology, Volume 5, Issue 2, June 2026.The functions of ribosomal proteins (RPs) extend beyond the conventional translation process, as they also regulate gene expression, stress responses, and disease progression. Dysregulation of RPs contributes to the onset and progression of various diseases, including cancer and ribosomopathies, underscoring their dual role as critical disease ...
Ao Zhang +4 more
wiley +1 more source
Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek +3 more
wiley +1 more source