Results 131 to 140 of about 23,580 (195)
Inhibition of Breast Cancer Cell Proliferation by 9-Hydroxycamptothecin-Loaded Zeolitic Imidazolate Nanoparticles. [PDF]
Oncol ResYang C +5 more
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Actin and myosin dynamics during epithelial remodeling in avian gastrulation
Ieda Y +4 more
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The Lancet, 2003
Supported by detailed understanding of their mechanism of action, and facilitated by chemical manipulations that have amplified their solubility, the camptothecins have advanced to the forefront of several areas of therapeutic and developmental chemotherapy. Additive and synergistic laboratory interactions with other cytotoxic drugs have been exploited
Joseph F, Pizzolato, Leonard B, Saltz
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Supported by detailed understanding of their mechanism of action, and facilitated by chemical manipulations that have amplified their solubility, the camptothecins have advanced to the forefront of several areas of therapeutic and developmental chemotherapy. Additive and synergistic laboratory interactions with other cytotoxic drugs have been exploited
Joseph F, Pizzolato, Leonard B, Saltz
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Drugs, 2002
Camptothecin analogues and derivatives appear to exert their antitumour activity by binding to topoisomerase I and have shown significant activity against a broad range of tumours. In general, camptothecins are not substrates for either the multidrug-resistance P-glycoprotein or the multidrug-resistance-associated protein (MRP).
Hulya, Ulukan, Peter W, Swaan
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Camptothecin analogues and derivatives appear to exert their antitumour activity by binding to topoisomerase I and have shown significant activity against a broad range of tumours. In general, camptothecins are not substrates for either the multidrug-resistance P-glycoprotein or the multidrug-resistance-associated protein (MRP).
Hulya, Ulukan, Peter W, Swaan
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Journal of Medicinal Chemistry, 1975
Several compounds having portions of the camptothecin ring system were prepared. These compounds were screened against L1210 lymphoid leukemia with negative results. Two of the analogs which contained the pyridine and hydroxylactone D and E rings were also screened for inhibition of DNA and RNA syntheses in HeLa cells.
S B, Horwitz +7 more
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Several compounds having portions of the camptothecin ring system were prepared. These compounds were screened against L1210 lymphoid leukemia with negative results. Two of the analogs which contained the pyridine and hydroxylactone D and E rings were also screened for inhibition of DNA and RNA syntheses in HeLa cells.
S B, Horwitz +7 more
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Camptothecin: Current Perspectives
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Craig J, Thomas +2 more
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Mechanisms of Resistance to Camptothecins
Annals of the New York Academy of Sciences, 2000Abstract:Camptothecins are broad‐spectrum anticancer drugs that specifically target DNA topoisomerase I. Although the availability of camptothecins has had a significant impact on cancer therapeutics, de novo or acquired clinical resistance to camptothecins is common.
A, Saleem +3 more
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Pharmaceutical Research, 2002
Camptothecin has shown significant antitumor activity to lung, ovarian, breast, pancreas, and stomach cancers. Camptothecin, however, like a number of other potent anticancer agents such as paclitaxel, is extremely water insoluble. Furthermore, pharmacology studies have determined that prolonged schedules of administration given continuously are ...
A, Hatefi, B, Amsden
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Camptothecin has shown significant antitumor activity to lung, ovarian, breast, pancreas, and stomach cancers. Camptothecin, however, like a number of other potent anticancer agents such as paclitaxel, is extremely water insoluble. Furthermore, pharmacology studies have determined that prolonged schedules of administration given continuously are ...
A, Hatefi, B, Amsden
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Mechanism of Action of Camptothecin
Annals of the New York Academy of Sciences, 2000Abstract:Camptothecin (CPT) class of compounds has been demonstrated to be effective against a broad spectrum of tumors. Their molecular target has been firmly established to be human DNA topoisomerase I (topo I). CPT inhibits topo I by blocking the rejoining step of the cleavage/religation reaction of topo‐I, resulting in accumulation of a covalent ...
Liu, L.F. +5 more
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Clinical pharmacology of camptothecins
Cancer Chemotherapy and Pharmacology, 1998Camptothecins (CPTs) are a unique class of chemotherapeutic agent which inhibit DNA synthesis by inhibiting topoisomerase I activity. Structure-activity studies on the original CPT alkaloid led to the development of the new analogues irinotecan (CPT-11), topotecan, and 9-aminocamptothecin, which have improved water solubility and lower toxicity.
L, Iyer, M J, Ratain
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