Results 141 to 150 of about 39,854 (281)

Effect of NaCl on growth, morphology, and camptothecin accumulation in Camptotheca acuminata seedlings

, 2003
NaCl salt is shown to increase alkaloid accumulation in some plant species, but creates an extensive problem in plant cultivation. The effect of NaCl on Camptotheca acuminata Decaisne growth, morphology, and camptothecin accumulation (concentration and ...
Liu, Zhijun, Zhijun Liu, Li, Zhanhai, Zhanhai Li and   +3 more
core   +1 more source

Antibody Targeting of Camptothecin-Loaded PLGA Nanoparticles to Tumor Cells

, 2008
Antibody targeting of drug substances can improve the efficacy of the active molecule, improving distribution and concentration of the drug at the site of injury/disease.
Fay, Francois, Scott, Christopher J.; id_orcid, Marouf, Waleed M., McCarron, Paul A., Quinn, Derek J., Burden, Roberta E., Olwill, Shane A.   +6 more
core   +1 more source

An unusual dimer of camptothecin-7-aldehyde

, 2004
An intermolecular aldol reaction of 20S-camptothecin-7-aldehyde in the presence of strong bases affords an unusual dimeric compound, the structure and stereochemistry of which was assigned on the basis of NMR analysis and MM2 ...
S. Dallavalle, L. Merlini, L. Musso
core   +1 more source

The impact of camptothecin-encapsulated poly(lactic-co-glycolic acid) nanoparticles on the activity of cytochrome P450 in vitro

, 2019
Hanmei Bao, Qing Zhang, Zhao Yan Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
Yan Z, Bao H, Zhang Q
core  

Semisynthesis of DB-67 and Other Silatecans from Camptothecin by Thiol-Promoted Addition of Silyl Radicals.

, 2003
Thiol- or acid-promoted additions of silyl radicals to camptothecin are reported. At 105 degrees C, mixtures of 7-silyl (favored) and 12-silyl camptothecins are formed alongside substantial amounts of recovered camptothecin.
Curran, Dennis P, Kaskar, Bashir, Blumbergs, Peter, Subramanian, P-K, Du, Wu   +4 more
core   +1 more source

The biosynthesis of camptothecin derivatives by Camptotheca acuminata seedlings

, 2019
10-hydroxycamptothecin and 9-methoxycamptothecin, naturally occurring camptothecin derivatives, are reportedly present in Camptotheca acuminata with a powerful cytotoxic effect and strong antitumor activity.
Ning Zhang (23771), Jianli Liu (1529092), Xiao Bai (2546572), Yahui Wei (797524), Cuiling Wang (359625), Yanni Sun (27928)   +5 more
core   +1 more source

Future-Oriented Nanosystems Composed of Polyamidoamine Dendrimer and Biodegradable Polymers as an Anticancer Drug Carrier for Potential Targeted Treatment

Pharmaceutics
Background/Objectives: Camptothecin (CPT) is a well-known chemical compound recognized for its significant anticancer properties. However, its clinical application remains limited due to challenges related to CPT’s high hydrophobicity and the instability
Katarzyna Strzelecka, Adam Kasiński, Tadeusz Biela, Anita Bocho-Janiszewska, Anna Laskowska, Łukasz Szeleszczuk, Maciej Gawlak, Marcin Sobczak, Ewa Oledzka   +8 more
doaj   +1 more source

Water Soluble Derivatives of Camptothecin/Homocamptothecin

, 2001
Camptothecin and homocamptothecin analogs and derivatives are provided incorporating alkylamine and polyalkylamine ...
Burke, Thomas, Chavan, Ashok J., Wang, Tie-Lin, Demir, Ayhan, Tanyeli, Cihangir, Pommier, Yves   +5 more
core  

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

The direct conversion of strictosamide to pumiloside <i>in planta</i> expands the camptothecin biosynthetic pathway. [PDF]

Synth Syst Biotechnol
Li Y, Wu Z, Chen J, Ruan Q, Yao L, Shao L, Hao X, Kai G.   +7 more
europepmc   +1 more source