Results 101 to 110 of about 18,515 (223)
Advanced Science, Volume 13, Issue 52, 18 September 2026.This review redefines radiotherapy‐triggered drug delivery systems through structural disassembly and molecular actuation, proposing a translation‐oriented framework for dose‐correlated activation to advance clinically integrated precision oncology. ABSTRACT Radiotherapy‐triggered drug delivery systems (RDDS) promise to integrate the spatial precision ...
Jianv Jiang +3 more
wiley +1 more source
Cytotoxic Effects of Fascaplysin against Small Cell Lung Cancer Cell Lines
Marine Drugs, 2014 Fascaplysin, the natural product of a marine sponge, exhibits anticancer activity against a broad range of tumor cells, presumably through interaction with DNA, and/or as a highly selective cyclin-dependent kinase 4 (CDK4) inhibitor.
Gerhard Hamilton
doaj +1 more source
Effect of camptothecin reversal on RNA synthesis.
, 2013 (A), Aggregate view of RNA synthesis of genes larger than 100 kb in normal human fibroblasts with the genes aligned by transcriptional start sites (TSS).
Benjamin Biewen (476021) +9 more
core +1 more source
Molecules, 2019 Cell-penetrating peptide [WR]5 has been previously shown to be an efficient molecular transporter for various hydrophilic and hydrophobic molecules. The peptide was synthesized using Fmoc/tBu solid-phase chemistry, and one arginine was replaced with one ...
Naglaa Salem El-Sayed +5 more
doaj +1 more source
Mathematical models characterising the kinetics and dynamics of topotecan to account for drug resistance mechanisms [PDF]
This thesis describes the use of mathematical modelling in studying the kinetics and dynamics of the anti-cancer agent topotecan (TPT), a semi-synthetic derivative of the natural extract camptothecin (CPT), which has been found to act as an inhibitor ...
Atari, M. I. (Mohammed Isam)
core
Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates
ACS Medicinal Chemistry Letters, 2019 Antibody–drug conjugates (ADCs) that incorporate the exatecan derivative DXd in their payload are showing promising clinical results in solid tumor indications. The payload has an F-ring that also contains a second chiral center, both of which complicate
Wei Li +17 more
semanticscholar +1 more source
BMEMat, Volume 4, Issue 3, September 2026.We constructed a Pt‐TiO2 mesoporous nanocarrier to co‐deliver phlorizin for HCC synergistic sonodynamic‐chemoimmunotherapy. This nanoplatform targets DDX5 to remodel tumor metabolism, triggers mitochondrial damage, suppresses tumor proliferation, and elicits potent anti‐tumor immune responses by activating T cells and boosting immune cytokines in mice.
Kairui Liu +13 more
wiley +1 more source
International Journal of Molecular Sciences, 2019 The plant Ophiorrhiza pumila produces camptothecin (CPT), a kind of terpene indole alkaloid (TIAs) that has been widely used in treatment of cancer. Tryptophan-arginine-lysine-tyrosine (WRKY) transcription factors have been reported to play important ...
Can Wang +7 more
semanticscholar +1 more source
Reactive Oxygen Species in Breast Cancer: From Redox Dysregulation to ROS‐Responsive Therapeutics
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT Breast cancer is the most frequently diagnosed malignancy among women worldwide, with 2.3 million new cases and approximately 670,000 deaths reported in 2022 alone. Despite advances in therapy, metastasis and acquired drug resistance remain major clinical challenges.
Marija Nikolovska +5 more
wiley +1 more source
Water Soluble Derivatives of Camptothecin/Homocamptothecin [PDF]
, 2001 Camptothecin and homocamptothecin analogs and derivatives are provided incorporating alkylamine and polyalkylamine ...
Burke, Thomas +5 more
core +1 more source