Results 101 to 110 of about 39,854 (281)

Enhanced cytotoxic effect of camptothecin nanosponges in anaplastic thyroid cancer cells in vitro and in vivo on orthotopic xenograft tumors

Drug Delivery, 2017
Anaplastic carcinoma of the thyroid (ATC) is a lethal human malignant cancer with median survival of 6 months. To date, no treatment has substantially changed its course, which makes urgent need for the development of novel drugs or novel formulations ...
Casimiro Luca Gigliotti, Benedetta Ferrara, Sergio Occhipinti, Elena Boggio, Giuseppina Barrera, Stefania Pizzimenti, Mirella Giovarelli, Roberto Fantozzi, Annalisa Chiocchetti, Monica Argenziano, Nausicaa Clemente, Francesco Trotta, Caterina Marchiò, Laura Annaratone, Renzo Boldorini, Umberto Dianzani, Roberta Cavalli, Chiara Dianzani   +17 more
doaj   +1 more source

Multi‐Induction Strategies in Crops: Mechanisms, Synergistic Effects, and Sustainable Applications for Enhanced Secondary Metabolite Production

Food Frontiers, Volume 7, Issue 4, July 2026.
This review analyzes single/combined abiotic (light, water, nutrients, hormones) and biotic (microbes, yeast) elicitors regulating signaling, gene expression, and metabolism to boost plant secondary metabolites. It highlights synergistic multielicitor strategies for crop quality and functional foods, while critically addressing current limitations and ...
Yifei Sun, Daoyan Xiao, Xingyue Li, Zhaofei Wang, Maoqin Xia, Chao Song, Hong‐Lei Li   +6 more
wiley   +1 more source

Mathematical models characterising the kinetics and dynamics of topotecan to account for drug resistance mechanisms [PDF]

This thesis describes the use of mathematical modelling in studying the kinetics and dynamics of the anti-cancer agent topotecan (TPT), a semi-synthetic derivative of the natural extract camptothecin (CPT), which has been found to act as an inhibitor ...
Atari, M. I. (Mohammed Isam)
core  

De novo genome assembly of Camptotheca acuminata, a natural source of the anti-cancer compound camptothecin

GigaScience, 2017
Camptotheca acuminata is 1 of a limited number of species that produce camptothecin, a pentacyclic quinoline alkaloid with anti-cancer activity due to its ability to inhibit DNA topoisomerase.
Dongyan Zhao, J. Hamilton, Gina M. Pham, Emily Crisovan, Krystle Wiegert-Rininger, Brieanne Vaillancourt, D. DellaPenna, C. R. Buell   +7 more
semanticscholar   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Preparação, caracterização e avaliação da eficácia terapêutica de microesferas de camptotecina preparadas a partir da poli-£-caprolactona [PDF]

, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia.A camptotecina é um fármaco que apresenta uma considerável atividade antitumoral cujo mecanismo de ação envolve a ...
Dora, Cristiana Lima
core  

Camptothecin accumulation in Camptotheca acuminata seedlings in response to acetylsalicylic acid treatment

, 2004
Camptothecin is an anti-cancer alkaloid. Acetylsalicylic acid (ASA) treatment was evaluated as a potential tool for increasing camptothecin accumulation (concentration and yield) in Camptotheca acuminata.
Liu, Zhijun, Zhijun Liu, Li, Zhanhai, Zhanhai Li   +3 more
core   +1 more source

Camptothecin suppresses NRF2–ARE activity and sensitises hepatocellular carcinoma cells to anticancer drugs

British Journal of Cancer, 2017
Background:Resistance to chemotherapy is a major obstacle in the treatment of human hepatocellular carcinoma (HCC). Despite playing an important role in chemoprevention, nuclear factor erythroid 2-related factor 2 (NRF2) also contributes to chemo- and ...
Feng Chen, Feng Chen, Huihui Wang, Jiayu Zhu, Rui Zhao, Peng Xue, Qiang Zhang, M. Nelson, Weidong Qu, Bo Feng, J. Pi   +10 more
semanticscholar   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, Volume 13, Issue 34, 19 June 2026.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Camptothecin-based nanodrug delivery systems

Cancer Biology and Medicine, 2017
The drug camptothecin has a wide range of antitumor effects in cancers including gastric cancer, rectal and colon cancer, liver cancer, and lung cancer.
Yan Wen, Yingze Wang, Xiaoling Liu, Wei Zhang, Xinhe Xiong, Zhongxiao Han, Xing-jie Liang   +6 more
semanticscholar   +1 more source