Results 51 to 60 of about 5,743 (138)

Deconvolution of bulk blood eQTL effects into immune cell subpopulations

BMC Bioinformatics, 2020
Background Expression quantitative trait loci (eQTL) studies are used to interpret the function of disease-associated genetic risk factors. To date, most eQTL analyses have been conducted in bulk tissues, such as whole blood and tissue biopsies, which ...
Raúl Aguirre-Gamboa, Niek de Klein, Jennifer di Tommaso, Annique Claringbould, Monique GP van der Wijst, Dylan de Vries, Harm Brugge, Roy Oelen, Urmo Võsa, Maria M. Zorro, Xiaojin Chu, Olivier B. Bakker, Zuzanna Borek, Isis Ricaño-Ponce, Patrick Deelen, Cheng-Jiang Xu, Morris Swertz, Iris Jonkers, Sebo Withoff, Irma Joosten, Serena Sanna, Vinod Kumar, Hans J. P. M. Koenen, Leo A. B. Joosten, Mihai G. Netea, Cisca Wijmenga, BIOS Consortium, Lude Franke, Yang Li   +28 more
doaj   +1 more source

Characterization of retinal pigment epithelium layer in healthy and diseased retinas with high‐resolution adaptive optics transscleral flood illumination imaging

Acta Ophthalmologica, Volume 104, Issue 3, Page e277-e291, May 2026.
Abstract Purpose The retinal pigment epithelium (RPE) is critical in the pathophysiology of retinal diseases, such as age‐related macular degeneration. Adaptive optics transscleral flood illumination (AO‐TFI) offers rapid, detailed morphometric characterization of the RPE layer.
Leila Sara Eppenberger, Safa Mohanna, Sohrab Ferdowsi, Sonja Simon‐Zoula, Oliver Pfäffli, Christoph Amstutz, Lucas M. Bachmann, Michael A. Thiel, Martin K. Schmid   +8 more
wiley   +1 more source

Development of an international Core Outcome Set (COS) for best care for the dying person: study protocol

BMC Palliative Care, 2020
Background In contrast to typical measures employed to assess outcomes in healthcare such as mortality or recovery rates, it is difficult to define which specific outcomes of care are the most important in caring for dying individuals.
Sofia C. Zambrano, Dagny Faksvåg Haugen, Agnes van der Heide, Vilma A. Tripodoro, John Ellershaw, Carl Johan Fürst, Raymond Voltz, Stephen Mason, María L. Daud, Gustavo De Simone, Kerstin Kremeike, Svandis Iris Halfdanardottir, Valgerdur Sigurdardottir, Jeremy Johnson, Simon Allan, Haroon Hafeez, Catarina Simões, Katrin Ruth Sigurdardottir, Birgit H. Rasmussen, Paula Williamson, Steffen Eychmüller, in collaboration with the iLIVE consortium   +21 more
doaj   +1 more source

Do adults with cardiovascular disease risk show meaningful reactivity to physical activity measurement? Coordinated analysis across six studies

British Journal of Health Psychology, Volume 31, Issue 2, May 2026.
Abstract Objectives To estimate the extent of physical activity (PA) measurement reactivity among adults ages 40–60 with risk factors for cardiovascular disease (CVD), to inform best practices for addressing reactivity in PA research and intervention.
Danielle Arigo, Kiri Baga, Amanda L. Folk, Gabrielle M. Salvatore, Iris Bercovitz, Ria Singh, Laura M. König, Meghan L. Butryn, Jacqueline A. Mogle   +8 more
wiley   +1 more source

Remote Text‐Supplemented Audiobook Intervention Supports Children's Explicit and Incidental Vocabulary Learning

Developmental Science, Volume 29, Issue 3, May 2026.
ABSTRACT Vocabulary knowledge is foundational to educational success, but significant gaps exist between students with reading disabilities or those from disadvantaged backgrounds and their peers. These gaps have cascading effects, as children with lower vocabulary knowledge are less likely to acquire new words through independent reading and are less ...
Halie A. Olson, Ola Ozernov‐Palchik, Xochitl M. Arechiga, John D. E. Gabrieli   +3 more
wiley   +1 more source

The effect of family-centered care on unplanned emergency room visits, hospital readmissions and intensive care admissions after surgery: a root cause analysis from a prospective multicenter study in the Netherlands

Patient Safety in Surgery
Background Optimizing transitional care by practicing family-centered care might reduce unplanned events for patients who undergo major abdominal cancer surgery. However, it remains unknown whether involving family caregivers in patients’ healthcare also
Sani Marijke Kreca, Iris Sophie Albers, Selma Clazina Wilhelmina Musters, Els Jaqueline Maria Nieveen van Dijkum, Pieter Roel Tuinman, Anne Maria Eskes, on behalf of the ARTIS consortium   +6 more
doaj   +1 more source

MAIT cells are activated during human viral infections

Nature Communications, 2016
Mucosal Associated Invariant T cells have been implicated in response to bacterial pathogens. Here the authors show that in human viral infections, these cells are activated by IL-18 in cooperation with other pro-inflammatory cytokines, producing ...
Bonnie van Wilgenburg, Iris Scherwitzl, Edward C. Hutchinson, Tianqi Leng, Ayako Kurioka, Corinna Kulicke, Catherine de Lara, Suzanne Cole, Sirijitt Vasanawathana, Wannee Limpitikul, Prida Malasit, Duncan Young, Laura Denney, STOP-HCV consortium, Michael D. Moore, Paolo Fabris, Maria Teresa Giordani, Ye Htun Oo, Stephen M. Laidlaw, Lynn B. Dustin, Ling-Pei Ho, Fiona M. Thompson, Narayan Ramamurthy, Juthathip Mongkolsapaya, Christian B. Willberg, Gavin R. Screaton, Paul Klenerman   +26 more
doaj   +1 more source

Reproducibility of cognitive endpoints in clinical trials: lessons from neurofibromatosis type 1

Annals of Clinical and Translational Neurology, 2019
Objective Rapid developments in understanding the molecular mechanisms underlying cognitive deficits in neurodevelopmental disorders have increased expectations for targeted, mechanism‐based treatments.
Jonathan M. Payne, Stephen J. C. Hearps, Karin S. Walsh, Iris Paltin, Belinda Barton, Nicole J. Ullrich, Kristina M. Haebich, David Coghill, Gerard A. Gioia, Alan Cantor, Gary Cutter, James H. Tonsgard, David Viskochil, Celiane Rey‐Casserly, Elizabeth K. Schorry, Joseph D. Ackerson, Laura Klesse, Michael J. Fisher, David H. Gutmann, Tena Rosser, Roger J. Packer, Bruce Korf, Maria T. Acosta, Kathryn N. North, the NF Clinical Trials Consortium   +24 more
doaj   +1 more source

Psychiatrists effect on positive symptom severity and daily functioning during pharmacotherapy for first-episode psychosis patients

Scientific Reports
Clinical outcomes after a first-episode of psychosis (FEP) are heterogeneous. Many patient-related factors such as gender and comorbidity have been studied to predict symptomatic outcomes.
Franciska de Beer, Sanne Koops, Robert A. Schoevers, Wim Veling, Nico van Beveren, Lieuwe de Haan, Nynke Boonstra, Martijn Kikkert, Marieke J. H. Begemann, HAMLETT-OPHELIA Consortium, Joran Lokkerbol, Iris E. C. Sommer   +11 more
doaj   +1 more source

Correction: Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.

PLoS Medicine, 2018
[This corrects the article DOI: 10.1371/journal.pmed.1002487.].
Iris Broce, Celeste M Karch, Natalie Wen, Chun C Fan, Yunpeng Wang, Chin Hong Tan, Naomi Kouri, Owen A Ross, Günter U Höglinger, Ulrich Muller, John Hardy, International FTD-Genomics Consortium, Parastoo Momeni, Christopher P Hess, William P Dillon, Zachary A Miller, Luke W Bonham, Gil D Rabinovici, Howard J Rosen, Gerard D Schellenberg, Andre Franke, Tom H Karlsen, Jan H Veldink, Raffaele Ferrari, Jennifer S Yokoyama, Bruce L Miller, Ole A Andreassen, Anders M Dale, Rahul S Desikan, Leo P Sugrue   +29 more
doaj   +1 more source