Results 51 to 60 of about 19,638 (210)

Building a Robust Investigator‐Initiated Platform: The I‐CARE Experience

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Investigator‐initiated studies that include information collected by patients are rising, but limited data is available on patient and investigator experience in this setting. The I‐CARE cohort included patients with inflammatory bowel disease (IBD) monthly collecting clinical information in 15 countries for up to 6 years.
Julien Kirchgesner   +906 more
wiley   +1 more source

Sudden unexpected death in epilepsy (SUDEP): Risk management of pediatric patients with epilepsy

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in people with epilepsy with an incidence of 1:1000. The primary risk factors for SUDEP are generalized or focal to bilateral tonic–clonic seizures. Preventive measures like nighttime monitoring devices and resuscitation training address modifiable risk factors.
Laura Lutz   +3 more
wiley   +1 more source

High Fidelity System Modeling for High Quality Image Reconstruction in Clinical CT [PDF]

open access: yes, 2014
Today, while many researchers focus on the improvement of the regularization term in IR algorithms, they pay less concern to the improvement of the fidelity term.
Brady, Tom   +6 more
core   +2 more sources

Postenucleation adjuvant chemotherapy with vincristine, etoposide, and carboplatin for the treatment of high-risk retinoblastoma. [PDF]

open access: yes, 2011
BACKGROUND: Analysis of 52 eyes with high-risk retinoblastoma managed with postenucleation adjuvant chemotherapy using vincristine sulfate, etoposide phosphate, and carboplatin showed no evidence of systemic metastasis in any case during a mean (range ...
Eagle, Ralph C   +5 more
core   +2 more sources

Molecular–clinical characteristics and treatment outcomes in 163 metastatic colorectal neuroendocrine carcinomas with a comparison to colorectal adenocarcinomas

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Colorectal neuroendocrine carcinoma (CR‐NEC) is a rare digestive neuroendocrine neoplasm that frequently exhibits an adenocarcinoma component. Nonetheless, the underlying biology of CR‐NEC remains poorly understood. This study examined molecular and clinical features and palliative chemotherapy outcomes of metastatic CR‐NEC, with comparison
Siren Morken   +20 more
wiley   +1 more source

A Novel murine model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression [PDF]

open access: yes, 2015
The introduction of highly selective ABL-tyrosine kinase inhibitors (TKIs) has revolutionized therapy for chronic myeloid leukemia (CML). However, TKIs are only efficacious in the chronic phase of the disease and effective therapies for TKI-refractory ...
Abdel-Wahab   +118 more
core   +3 more sources

Tolerability and efficacy of chemosaturation in combination with systemic therapy for metastatic uveal melanoma

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Uveal melanoma is the most common primary intraocular cancer in adults, and up to half of patients develop metastatic disease, predominantly in the liver, where prognosis remains poor despite promising treatment options. In this study, the authors evaluated the safety and efficacy of administering systemic therapy within 40 days of liver ...
Patrick Kasteleiner   +4 more
wiley   +1 more source

Association Between Colorectal Cancer Screening and Survival in Patients Older Than 70 Years: Results of A National Multicenter Retrospective Study

open access: yesJournal of Surgical Oncology, EarlyView.
ABSTRACT Background Colorectal cancer screening mainly targets a population between 50 and 70 years of age; however, it is inconsistently implemented in people over 70. The aim of this study was to analyze the association between colorectal cancer (CRC) screening, postoperative mortality, and perioperative and oncologic outcomes in a large population ...
Matteo Rottoli   +499 more
wiley   +1 more source

Uveítis en el complejo felino leucemia-linfosarcoma (Fellc) [PDF]

open access: yes, 1989
Se exponen dos modelos de uveítis en el Fellc, una relacionada con la viremia y otra debida a la infiltración tumoral. El carácter de inflamación granulornatosa, no aporta datos clínicos patognomónicas para la diferencia de otras uveítis sistémicas.We ...
Cascales, Mª J.   +4 more
core  

Expression and prognostic value of putative cancer stem cell markers CD117 and CD15 in choroidal and ciliary body melanoma [PDF]

open access: yes, 2015
AIMS: The aim of the present study was to immunohistochemically investigate the expression and prognostic significance of putative cancer stem cell markers CD117 (c-kit), CD34, CD20 and CD15 in a cohort of patients with primary choroidal and ciliary ...
Dotlić, Snježana   +5 more
core   +1 more source

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