Results 111 to 120 of about 19,243 (300)
Aging Cell, EarlyView.Exercise improved PD pathology and memory by reducing microglial inflammation, apoptosis, and the formation of the NLRP3 inflammasome via irisin signaling. Irisin administration partially replicated the beneficial effects of exercise on PD pathology.
Renqing Zhao +5 more
wiley +1 more source
Journal of Human Reproductive Sciences, 2021 Context: Irisin, a new myokine, has been found to be a biological marker of insulin resistance (IR). There is conflicting evidence on serum irisin level in adult women with polycystic ovarian syndrome (PCOS), and data are lacking in adolescents with PCOS.
Bhawina Sharan +3 more
doaj +1 more source
Laser-scanning cytometry can quantify human adipocyte browning and proves effectiveness of irisin [PDF]
, 2015 Laser-scanning cytometry is presented as a tool allowing population scale analysis of ex vivo human brown adipogenic differentiation. It combines texture analysis and detection of Ucp1 protein content in single brown adipocytes of mixed cell populations ...
Bacso, Zsolt +5 more
core +1 more source
Oxidative Medicine and Cellular Longevity, 2022 Iron‐dependent lipid peroxidation causes ferroptosis. This study was aimed at verifying that irisin postconditioning can inhibit ferroptosis and minimize lung ischemia/reperfusion (I/R) damage via activating the Nrf2/HO‐1 signal axis.
Yun Wang +5 more
semanticscholar +1 more source
Sirt3 Rescues Porphyromonas gingivalis‐Impaired Cementogenesis via SOD2 Deacetylation
Cell Proliferation, EarlyView.Sirt3 deacetylated SOD2 via K68 to orchestrate P.g.‐impaired cementogenesis. Reestablishment of the Sirt3/SOD2 axis by honokiol reduced SOD2 acetylation and facilitated cementogenesis. ABSTRACT The keystone pathogen Porphyromonas gingivalis (P.g.) is responsible for cementum resorption in periodontitis; however, the mechanism involved in it remains ...
Xin Huang +6 more
wiley +1 more source
Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo
eLife, 2020 Irisin, a skeletal-muscle secreted myokine, facilitates muscle-bone crosstalk and skeletal remodeling in part by its action on osteoblasts and osteocytes. In this study, we investigated whether irisin directly regulates osteoclasts.
Eben G Estell +9 more
doaj +1 more source
FNDC5/irisin, a molecular target for boosting reward-related learning and motivation [PDF]
, 2018 K
Gesztelyi, Rudolf +4 more
core +1 more source
Exercise Delays Brain Ageing Through Muscle‐Brain Crosstalk
Cell Proliferation, EarlyView.This graphical abstract illustrates the reciprocal crosstalk between the brain and peripheral organs, highlighting the profound impact of exercise on brain health through systemic interactions. It underscores how exercise influences the brain via signals from various organs and, conversely, how the brain modulates functions of peripheral organs.
Shirin Pourteymour +3 more
wiley +1 more source
Reproductive Biology and Endocrinology, 2021 Background Infertility is a common complication in obese men. Oxidative stress and testicular apoptosis play critical roles in obesity-induced spermatogenesis dysfunction.
Yang Mu +3 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2023 Adaptive neuroplasticity is a pivotal mechanism for healthy brain development and maintenance, as well as its restoration in disease- and age-associated decline. Management of mental disorders such as attention deficit hyperactivity disorder (ADHD) needs
Alhasan Abdulghani +4 more
semanticscholar +1 more source