Results 91 to 100 of about 18,190 (273)

Glutathione Decrement Drives Thermogenic Program in Adipose Cells [PDF]

, 2015
Adipose tissue metabolically adapts to external stimuli. We demonstrate that the induction of the thermogenic program in white adipocytes, through cold exposure in mice or in vitro adrenergic stimulation, is accompanied by a decrease in the intracellular
Aquilano, K, Bernardini, S, Cannata, S, Ciriolo, MR, Lettieri Barbato, D, Tatulli, G   +5 more
core   +1 more source

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, EarlyView.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source

Irisin: A myokine with locomotor activity [PDF]

Neuroscience Letters, 2015
The mechanisms underlying alterations in brain functions in response to physical exercise are not fully understood. The present study examined the central effect of irisin, a 112 amino acid polypeptide hormone secreted from the skeletal muscle after exercise, on the locomotion in rats.
Weizhen Zhang, Lin Chang, Chao Zhang, Ruthann Zhang, Ziru Li, Biaoxin Chai, Jiyao Li, Eugene Chen, Michael Mulholland   +8 more
openaire   +2 more sources

Study on changes in serum irisin level in free-flap transplantation and the correlation of serum irisin level with flap blood flow

Heliyon
Background and aims: The beneficial effect of myokine irisin on ischemia-reperfusion of skin flaps has been rarely reported in clinical studies. This study was designed to determine whether irisin plays a protective role in flap transplantation and ...
Xianyao Tao, Xiaoyun Pan, Gang Zhao, Yongjun Rui   +3 more
doaj   +1 more source

Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany [PDF]

, 2014
The 12th Stock Conference addressed body composition and related functions in two extreme situations, obesity and cancer cachexia. The concept of ‘functional body composition’ integrates body components into regulatory systems relating the mass of organs
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core   +2 more sources

Crosstalk between Irisin Levels, Liver Fibrogenesis and Liver Damage in Non-Obese, Non-Diabetic Individuals with Non-Alcoholic Fatty Liver Disease [PDF]

, 2022
Angelo Armandi, Chiara Rosso, Aurora Nicolosi, Gian Paolo Caviglia, Maria Lorena Abate, Antonella Olivero, Daphne D’Amato, Marta Vernero, Melania Gaggini, Giorgio Maria Saracco, Davide Giuseppe Ribaldone, Diana Julie Leeming, Amalia Gastaldelli, Elisabetta Bugianesi   +13 more
openalex   +1 more source

Urinary exosomes aggravate diabetic kidney disease by inducing podocyte ferroptosis via the miR‐217/SIRT1/Nrf2 pathway

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
These findings indicate that urinary exosomal miR‐217 promotes podocyte ferroptosis and DKD progression via suppression of the SIRT1/Nrf2 pathway, suggesting a potential therapeutic target for DKD. Abstract Urinary exosomal microRNAs (miRNAs) mediate intercellular communication in diabetic kidney disease (DKD), a leading contributor to end‐stage renal ...
Xin Du, Yubo Jiang, Hongbin Guo, Haiying Zhang, Shaoqing Wang, Hao Deng, Xinyi Huang, Xiu Li   +7 more
wiley   +1 more source

The Myokine Irisin Represents an Indirect Pathway Linking Exercise to Hippocampal Subfields Relevant to Alzheimer's Disease and Neurogenesis

Aging Cell, Volume 25, Issue 5, May 2026.
We provide the first human evidence that the exercise‐induced myokine irisin mediates the relationship between physical activity and hippocampal volume in older adults, with strongest effects in CA1, CA3 and CA4 subfields. These regions are critical for memory and particularly vulnerable to Alzheimer's disease.
Thomas Pace, Jacob M. Levenstein, Bonnie L. Quigley, Rhys Houston, Ana P. Bouças, Sophie C. Andrews   +5 more
wiley   +1 more source

Age-related changes to lumbosacral spinal cord motoneurons that modulate bladder and bowel functions in male C57BL/6 mice [PDF]

, 2013
Incontinence and sexual dysfunction are often increased in the aged human population. In rats and mice the pattern of micturition and faecal clearance also changes with ageing and is suggestive of bladder and bowel ...
Black, G., Ranson, R. N, Saffrey, M. J., Tsang, H., Zhang, M.   +4 more
core  

Physical activity and cardiovascular prevention: Is healthy urban living a possible reality or utopia? [PDF]

, 2017
Favoring correct lifestyles is the most important measure to contrast cardiovascular diseases and the epidemic of high cardiovascular risk conditions, such as obesity, diabetes, and hypertension.
Buscemi, S., Giordano, C.
core   +1 more source