Results 71 to 80 of about 4,586 (139)

Is Irisin Anticancer Agent?

, 2018
Irisin is a protein, which is encoded by the FNDC5 gene. Irisin secreted as a hormone secret via Fibronectin type III domain-containing protein 5. Irisin is always provide beneficial effect of exercise on cellular metabolism as well as obesity and ...
Işıl Yıldırım
core   +1 more source

Acute and lifelong exercise modulate the tumorigenic potential of human lung cancer cells and their susceptibility to cisplatin

Experimental Physiology, EarlyView.
Abstract The association between higher levels of physical activity and lower cancer risk and mortality is well established. However, a causal link is yet to be proven. Recent studies showed a decrease in the proliferation rates of cultured human cancer cells when the human serum used to stimulate them was conditioned by acute exercise. Here, we tested
Carlos M. Soares, João P. Moura, Leonardo M. R. Ferreira, Ana Pedrosa, Pedro Filipe, Luís Rama, Ana M. Teixeira, Ana M. Urbano   +7 more
wiley   +1 more source

Effects of hr-irisin on cell growth.

, 2015
A: SDS-PAGE and western blotting analysis of human irisin expressed in HEK 293 cells (hr-irisin). The culture medium of irisin transfected cells was harvested for analysis.
Avi Kandel (787302), Westley H. Reeves (74330), Yousong Ding (787304), Shiwu Li (460656), Yimu Lai (787303), Li-Jun Yang (368261), Hai Wang (310051), Tran D. N. Tran (787298), Haoyang Zhuang (787300), Yuan Zhang (41832), Henrique Cheng (751499), Peilan Zhang (787301), Chao Xie (524756), Dongqi Tang (136130), Eva Vertes George (787299)   +14 more
core   +1 more source

Study on changes in serum irisin level in free-flap transplantation and the correlation of serum irisin level with flap blood flow

Heliyon
Background and aims: The beneficial effect of myokine irisin on ischemia-reperfusion of skin flaps has been rarely reported in clinical studies. This study was designed to determine whether irisin plays a protective role in flap transplantation and ...
Xianyao Tao, Xiaoyun Pan, Gang Zhao, Yongjun Rui   +3 more
doaj   +1 more source

The association of circulating irisin with metabolic risk factors in Chinese adults: a cross-sectional community-based study

BMC Endocrine Disorders, 2019
Background Irisin is a myokine that leads to increased energy expenditure by stimulating the browning of white adipose tissue. We aimed to investigate the association of serum irisin levels with metabolic parameters in middle aged Chinese population ...
Lizhi Tang, Yuzhen Tong, Fang Zhang, Guilin Chen, Yun Cong Zhang, John Jobin, Nanwei Tong   +6 more
doaj   +1 more source

Role of Triceps Muscle Fiber‐Specific Myokines in Pancreatic β‐Cell Protection: Implications for Type 2 Diabetes: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Type 2 diabetes (T2D) is a major global health challenge, primarily driven by insulin resistance and progressive β‐cell dysfunction aggravated by chronic low‐grade inflammation. Skeletal muscle has emerged as a pivotal endocrine organ through the secretion of myokines, which exert systemic metabolic and immunomodulatory ...
Christian Tague, Dujardin Makeda, Hermann Yokolo, Joshua Ekouo   +3 more
wiley   +1 more source

Skeletal Muscle–Derived Extracellular Vesicles During Eccentric and Concentric Exercise Promote Muscle Regeneration After Injury

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Skeletal muscle injuries significantly impair mobility and function, yet effective therapeutic interventions remain limited. Both eccentric exercise (EE) and concentric exercise (CE) promote muscle repair, but the underlying mechanisms are not fully understood.
Yining Zhou, Xiaoyan Shao, Pan Zhang, Jiaquan Lin, Xiang Chen, Xueying An, Zhuoying Jiang, Haosheng Wang, Depeng Fang, Yansi Xian, Bin Liu, Tao Shen, Ying Chen, Keran Li, Hongpeng Liu, Ying Li, Qing Jiang, Baosheng Guo   +17 more
wiley   +1 more source

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

Association of Serum Irisin With Severity and Prognosis in Patients With Coronavirus Disease 2019: A Prospective Cohort Study [PDF]

Xinli Zhang,1,2,* Wennan Wang,1,3,* Ye Li,2 Xiaoning Liu,2 Liangzhu Zhang,2 Zhenyu Cheng,1,4 Mingyan Liu,1,4 Yu Wang,1,4 Lin Fu,1,4 Jin Yang1,4,5 1Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Anhui ...
Liu X, Li Y, Yang J, Liu M, Zhang X, Wang W, Fu L, Zhang L, Wang Y, Cheng Z   +9 more
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Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source