Results 71 to 80 of about 7,364 (142)

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science
Pulmonary vascular remodeling, which current therapeutic targets fail to alleviate disease severity, plays a key role in pulmonary arterial hypertension (PAH).
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
doaj   +1 more source

Relationship of irisin with disease severity and dopamine uptake in Parkinson's disease patients

NeuroImage: Clinical
Background: This study was designed to investigate the relationship of irisin with the severity of Parkinson’s disease (PD) and dopamine (DOPA) uptake in patients with PD and to understand the role of irisin in PD.
Xiaoxue Shi, Qi Gu, Chang Fu, Jianjun Ma, Dongsheng Li, Jinhua Zheng, Siyuan Chen, Zonghan She, Xuelin Qi, Xue Li, Shaopu Wu, Li Wang   +11 more
doaj   +1 more source

Irisin‐mediated muscle‐renal crosstalk as a protective mechanism against contrast‐induced acute kidney injury via cGAS‐STING signalling inhibition

Clinical and Translational Medicine
Background Contrast‐induced acute kidney injury (CI‐AKI) continues to pose a pressing clinical challenge during invasive cardiovascular procedures due to the limited availability of preventative strategies.
Long Peng, Suhua Li, Qiang Huang, Yuxiang Sun, Juan Sun, Ting Luo, Yanlin Wang, Zhaoyong Hu, Weiyan Lai, Hui Peng   +9 more
doaj   +1 more source

The relationship between serum irisin levels and renal function in patients with type 2 diabetes mellitus [PDF]

Caspian Journal of Internal Medicine
Background: Irisin, a myokine implicated in metabolic hemostasis, have been investigated in relation to type 2 diabetes mellitus (T2DM), yet findings on its serum levels and association with diabetic complications such as nephropathy remain inconsistent.
Robab Beigom Aboutorabi, Golrokh Hariri, Zahra Mazloum Khorasani, Hassan Mehrad-Majd   +3 more
doaj  

Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy

Immunity & Ageing
Background The accumulation of senescent microglia has been highlighted as a critical contributor to the progression of tauopathies. Irisin, a muscle-derived hormone produced by the proteolytic cleavage of Fibronectin-domain III containing 5 (FNDC5 ...
Cailin Wang, Xiufeng Wang, Shangqi Sun, Yanmin Chang, Piaopiao Lian, Hongxiu Guo, Siyi Zheng, Rong Ma, Gang Li   +8 more
doaj   +1 more source

Correction to “The Myokine Irisin Represents an Indirect Pathway Linking Exercise to Hippocampal Subfields Relevant to Alzheimer's Disease and Neurogenesis”

Aging Cell, Volume 25, Issue 6, June 2026.
wiley   +1 more source

Sex specific effects of irisin on the skeleton. [PDF]

Bone Res
Shimonty A, Bonewald LF.
europepmc   +1 more source

The myokine irisin ameliorates the secretory dysfunction of pancreatic β cells in experimental and human type 2 diabetes. [PDF]

Sci Adv
Marrano N, Borrelli A, Biondi G, Rella M, D'Oria R, Genchi VA, Caccioppoli C, Galasso V, Galluzzi G, Roberto L, Signorile A, Vincenti L, Aquilino F, Nano R, Baruzzi F, Moretti A, Lupo LG, Marchetti P, Piemonti L, Cignarelli A, Perrini S, Laviola L, Giorgino F, Natalicchio A.   +23 more
europepmc   +1 more source

Irisin promotes selective changes in hippocampal mitochondrial metabolism in mice. [PDF]

Biochem Biophys Rep
Fonseca AS, Chichierchio MS, Chauvet MG, de Freitas GB, Tosta A, de Lima TF, Formiga-Jr MA, Ribeiro FC, Ferreira ST, De Felice FG, Camacho-Pereira J, Lourenco MV.   +11 more
europepmc   +1 more source

Irisin Signaling Resistance in Myalgic Encephalomyelitis: A Proposed Mechanistic Framework for Post-Exertional Malaise Involving the TSP-1-HSP90α-αvβ5 Axis. [PDF]

Int J Mol Sci
Souma B, Elremaly W, Akoume MY, Elbakry M, Godbout C, Moreau A.   +5 more
europepmc   +1 more source