Results 51 to 60 of about 7,364 (142)
Seven days of warm‐water immersion enhances resting irisin and BDNF, but not klotho, in older men
Experimental Physiology, EarlyView.Abstract We examined whether seven consecutive days of warm‐water immersion could elevate resting and exercise‐induced levels of brain‐derived neurotrophic factor (BDNF), irisin and klotho in older adults. These biomarkers support cognitive and metabolic health, but their levels decline with age.
Joel M Garrett +6 more
wiley +1 more source
Precision NanomedicineIrisin is a myokine that stimulates browning of white adipocytes and enhances cortical bone mass during physical exercise. However, its short half-life limits its therapeutic potential, making sustained delivery systems desirable for bone tissue ...
Prashant Sadanandan +3 more
doaj +1 more source
Experimental Physiology, EarlyView.Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari +7 more
wiley +1 more source
Biodegradable Natural Polymer‐Based Drug Delivery Systems for Bone Tissue Engineering
Medicinal Research Reviews, Volume 46, Issue 4, Page 966-988, July 2026.ABSTRACT The increasing incidence of bone diseases and injuries, especially among aging populations, has underscored the shortcomings of traditional treatments such as bone grafts and metal implants, which often face complications including immune rejection, mechanical failure, and delayed healing.
Hyejin Jo +4 more
wiley +1 more source
Obesity Reviews, Volume 27, Issue 7, July 2026.ABSTRACT Obesity as a chronic and multifactorial disease requires a multidisciplinary team acting together in a holistic multitarget intervention. Multidisciplinary therapy targeting obesity and its complications includes physical exercise, nutritional, and behavior counseling.
Ana Raimunda Dâmaso +7 more
wiley +1 more source
Brain and Behavior, Volume 16, Issue 6, June 2026.ABSTRACT Purpose This study examined the relationship between body composition and cardiac autonomic nervous system activity in educators. The objective was to explore the associations between body fat mass (BFM) and fat‐free mass (FFM) with different heart rate variability (HRV) indices in a sample of educators and to assess whether FFM moderates the ...
Estela Álvarez‐Gallardo +4 more
wiley +1 more source
Brain and Behavior, Volume 16, Issue 6, June 2026.In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence +14 more
wiley +1 more source
HeliyonBackground and aims: The beneficial effect of myokine irisin on ischemia-reperfusion of skin flaps has been rarely reported in clinical studies. This study was designed to determine whether irisin plays a protective role in flap transplantation and ...
Xianyao Tao +3 more
doaj +1 more source
Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.These findings indicate that urinary exosomal miR‐217 promotes podocyte ferroptosis and DKD progression via suppression of the SIRT1/Nrf2 pathway, suggesting a potential therapeutic target for DKD. Abstract Urinary exosomal microRNAs (miRNAs) mediate intercellular communication in diabetic kidney disease (DKD), a leading contributor to end‐stage renal ...
Xin Du +7 more
wiley +1 more source
International Journal of Endocrinology, 2014 Objectives. Sclerostin, an osteocyte-specific protein, has been found to be related to adiposity and glucose metabolism. Irisin, a myokine, can affect browning of white fat and influence glucose and energy homeostasis.
Theerawut Klangjareonchai +7 more
doaj +1 more source