Results 51 to 60 of about 18,190 (273)

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

eLife, 2020
Irisin, a skeletal-muscle secreted myokine, facilitates muscle-bone crosstalk and skeletal remodeling in part by its action on osteoblasts and osteocytes. In this study, we investigated whether irisin directly regulates osteoclasts.
Eben G Estell, Phuong T Le, Yosta Vegting, Hyeonwoo Kim, Christiane Wrann, Mary L Bouxsein, Kenichi Nagano, Roland Baron, Bruce M Spiegelman, Clifford J Rosen   +9 more
doaj   +1 more source

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Irisin inhibits pancreatic cancer cell growth via the AMPK-mTOR pathway

Scientific Reports, 2018
Irisin, a recently identified myokine that is released from skeletal muscle following exercise, regulates body weight and influences various metabolic diseases such as obesity and diabetes.
Jiayu Liu, Nannan Song, Yibing Huang, Yuxin Chen   +3 more
doaj   +1 more source

Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases [PDF]

, 2014
Physical inactivity is a predisposing factor for various disease states including obesity, cardiovascular disease, as well as for certain types of cancer. Regular endurance exercise mediates several beneficial effects such as increased energy expenditure
Handschin, Christoph, Svensson, Kristoffer   +1 more
core   +1 more source

An ultra‐processed food‐based cafeteria diet induces obesity, metabolic dysfunction, and tissue‐specific gene dysregulation in C57BL/6 mice

Animal Models and Experimental Medicine, EarlyView.
This schematic figure illustrates the experimental design and key findings of the study. Forty male C57BL/6 mice were assigned to either a standard diet control group or a cafeteria diet (CAFD) group for 16 weeks. CAFD induces obesity, insulin resistance (HOMA‐IR), hepatic steatosis, and dysregulation of a number of genes in visceral and subcutaneous ...
Guilherme Coutinho Kullmann Duarte, Daisy Crispim, Shiva Cerutti Wittée, Joana Raquel Nunes Lemos, Natalia Emerim Lemos, Mayara Souza de Oliveira, Melissa Daniele Alves, Eloísa Toscan Massignam, Tais Silveira Assmann, Felipe Mateus Pellenz   +9 more
wiley   +1 more source

Irisin – der neue Schlankmacher?

, 2013
Einleitung: Irisin ist ein Hormon, welches vom Muskel infolge von Aktivität ausschüttet wird. Beschrieben ist eine direkte Wirkung auf das Fettgewebe, da Irisin die Transdifferenzierung von weißem zu braunem Fettgewebe stimuliert. Aufgrund dieser Erkenntnis bestand die Frage, ob Irisin[for full text, please go to the a.m. URL]
Schäfer, B, Hemmrich, K, Paul, N, Fehsel, K, Pallua, N   +4 more
openaire   +2 more sources

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Disordered metabolism in mice lacking irisin [PDF]

Scientific Reports, 2020
AbstractIrisin is a product of fibronectin type III domain-containing protein (Fndc5) and is involved in the regulation of adipokine secretion and the differentiation of osteoblasts and osteoclasts. In this study, we aimed to determine whether irisin lacking affects glucose/lipid and bone metabolism.
Luo, Yunyao, Qiao, Xiaoyong, Ma, Yaxian, Deng, Hongxia, Xu, Charles C., Xu, Liangzhi   +5 more
openaire   +2 more sources

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Irisin reduces senile osteoporosis by inducing osteocyte mitophagy through Ampk activation

iScience
Summary: Irisin, an exercise-induced myokine, is known to be able to regulate bone metabolism. However, the underlying mechanisms regarding the effects of irisin on senile osteoporosis have not been fully elucidated. Here, we demonstrated that irisin can
Honghan Li, Deqing Luo, Wei Xie, Wenbin Ye, Jinlong Chen, Paolo Alberton, Mingzhu Zhang, Eryou Feng, Denitsa Docheva, Dasheng Lin   +9 more
doaj   +1 more source