Results 51 to 60 of about 4,586 (139)

Irisin is more strongly associated with leisure-time physical activity than resistin and high-density lipoprotein cholesterol are

Journal of Exercise Science & Fitness, 2022
Background/Objectives: Irisin is a myokine with a potential role in cardiometabolic diseases, but previous studies have described inconsistencies between serum irisin and physical activity (PA).
María del Cristo Rodríguez-Pérez, Titta Katariina Kontro, Delia Almeida González, Beatriz Gómez Álvarez, Itahisa Marcelino Rodríguez, y Antonio Cabrera de León   +5 more
doaj   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Circulating Irisin Is Reduced in Male Patients with Type 1 and Type 2 Myotonic Dystrophies

Frontiers in Endocrinology, 2017
ContextMyotonic dystrophies (DM) are dominantly inherited muscle disorders characterized by myotonia, muscle weakness, and wasting. The reasons for sarcopenia in DMs are uncleared and multiple factors are involved. Irisin, a positive hormone regulator of
Elena Dozio, Elena Passeri, Rosanna Cardani, Stefano Benedini, Carmen Aresta, Rea Valaperta, Massimiliano Corsi Romanelli, Massimiliano Corsi Romanelli, Giovanni Meola, Giovanni Meola, Valeria Sansone, Valeria Sansone, Sabrina Corbetta, Sabrina Corbetta   +13 more
doaj   +1 more source

Schisandrin C Targets PPARγ to Induce Ferroptosis in Colorectal Cancer Cells and Promote M1 Macrophage Polarization

Phytotherapy Research, EarlyView.
Schisandrin C: A Dual Anti‐Colorectal Cancer Strategy Targeting PPARγ. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer mortality, necessitating novel therapeutic strategies. Schisandrin C (SinC), a bioactive lignan from Schisandra chinensis, exhibits diverse pharmacological activities, but its anti‐CRC mechanisms are poorly ...
Xiao Wei, Hong‐Ping Wen, Jian‐Bo Song, Jin‐Fang Xu, Hong‐Rui Guo   +4 more
wiley   +1 more source

Supervised Short-term High-intensity Training on Plasma Irisin Concentrations in Type 2 Diabetic Patients.

, 2019
Irisin is a myokine involved in adipocyte transformation. Its main beneficial effects arise from increased energy expenditure. Irisin production is particularly stimulated by physical exercise.
Schobersberger, Wolfgang, Grander, Wilhelm, Melmer, Andreas, Dünnwald, Tobias, Gatterer, Hannes, Salzmann, Karin, Ebenbichler, Christoph, Burtscher, Martin   +7 more
core   +1 more source

Irisin ameliorates bone loss in ovariectomized mice

, 2020
Purpose: This study aimed to evaluate the effects of irisin on bones of ovariectomized (OVX) mice, to explore a possible treatment for postmenopausal osteoporosis.
Y. Luo (1398985), C. C. Xu (8746737), S. Li (1624891), Y. Nie (4696801), R. Zeng (8746731), X. Qiao (8746728), X. Shen (1439452), R. A (8746734), Y. Ma (6554882), M. Yang (1857409), L. Xu (2475667), R. Cheng (2844356)   +11 more
core   +1 more source

Irisin/FNDC5: A participant in camel metabolism [PDF]

, 2021
ArticleThe quantification, localization, production, function, and regulation of irisin/FNDC5 in camel species have not been previously studied. The objective of this study was to detect the irisin content in Arabian camel blood and tissues and study the
Kirat, Doaa, 23823, 9412, Moustafa, Amira, MIYASHO, Taku, 23821, Hamada, Mohamed, 23822, 6518, 宮庄, 拓   +9 more
core   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

Irisin: 'fat' or artefact

, 2015
Soon after the discovery of the muscle-derived factor irisin, a great controversy arose in the literature regarding certain inconsistencies in the regulation of the fibronectin type III domain containing 5 protein (FNDC5/irisin) after exercise, as well ...
Crujeiras Martínez, Ana Belén, Casanueva Freijo, Felipe, Pardo Pérez, María   +2 more
core   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source