Results 31 to 40 of about 4,586 (139)

Expression, purification and biological characterisation of recombinant human irisin (12.5 kDa)

Journal of Genetic Engineering and Biotechnology, 2018
Fibronectin type III domain containing 5 (FNDC5) is a transmembrane protein. Upon cleavage, it yields a peptide called irisin that is supposedly bind to an unknown receptor and facilitates browning of white adipose tissue (WAT).
Kalpana Panati, Venkata Ramireddy Narala, Vydyanath R. Narasimha, Madhavi Derangula, Venkat R.R. Arva Tatireddigari, Suneetha Yeguvapalli   +5 more
doaj   +1 more source

The identification of irisin in human cerebrospinal fluid : influence of adiposity, metabolic markers, and gestational diabetes

, 2014
Peripheral action of irisin improves glucose homeostasis and increases energy expenditure, with no data on a central role of irisin in metabolism. These studies sought to examine 1) presence of irisin in human cerebrospinal fluid (CSF) and banked human ...
Barber, T. M, Saravanan, Ponnusamy, Piya, Milan K. (R19111), Al-Daghri, N, M, Barber, Thomas M., Voyias, P. D, Saravanan, P., Tripathi, G, McTernan, P. G, Al-Daghri, Nasser M., Kumar, S., McTernan, Philip G., Voyias, PD, Sivakumar, Kavitha, Piya, Milan K, Sabico, S, James, S, Piya, Milan K., Tripathi, Gyanendra, James, S., McTernan, P. G., Piya, M.K., Al-Daghri, NM, Vatish, M, Barber, T.M., Al-Daghri, N.M., Harte, A.L., Piya, MK, Saravanan, P, Voyias, Philip D., Voyias, P.D., Sabico, Shaun, McTernan, PG, Barber, TM, Sivakumar, K, Vatish, M., Vatish, Manu, Tripathi, G., James, Sean, Barber, T. M., Harte, AL, Harte, A. L, Sivakumar, K., Harte, Alison L., Kumar, Sudhesh, Sabico, S., Harte, A. L., McTernan, P.G., Kumar, S   +48 more
core   +1 more source

Irisin—A Pancreatic Islet Hormone

, 2022
Irisin is a myokine involved in glucose homeostasis. It is primarily expressed in skeletal muscle, but also in the pancreas. This study aimed to elucidate its presence and role in the islets of Langerhans—i.e., its effect on insulin and glucagon ...
Espes, Daniel,, Espes, Daniel, Carlsson, Per-Ola,, Daniel Espes, Drott, Carl Johan,, Norman, Daniel, Carl Johan Drott, Daniel Norman, Carlsson, Per-Ola, Norman, Daniel,, Drott, Carl Johan, Per-Ola Carlsson   +11 more
core   +1 more source

Pengaruh Irisin pada Pencoklatan Lemak Putih [PDF]

, 2021
Introduction: Irisin is a new myokine that links physical activity to increased metabolic performance and is associated with the browning of white adipose tissue to brown. Objective: To determine the effect of irisin on the browning of white fat. Methods:
Danayati, Natalia
core   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Irisin — the future of ischemic stroke therapy? [PDF]

, 2023
Irisin is a recently discovered hormone, synthesized mainly by the muscles. Expression of irisin and its precursor named FNDC5 was also found in the heart, kidneys, liver, pancreas, adipose tissue, and brain including cortical neurons, hippocampus ...
Przywara, Stanisław; Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, al. Solidarności 8, 20-841 Lublin, Poland, Grześkiewicz, Magda; Student Research Group at the Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, Poland, Drewniak, Hubert; Student Research Group at the Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, Poland, Terlecki, Piotr; Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, al. Solidarności 8, 20-841 Lublin, Poland, Kobak, Joanna Elżbieta; Student Research Group at the Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, Poland   +4 more
core   +1 more source

Role of irisin in Chinese patients with hypothyroidism: an interventional study

Journal of International Medical Research, 2019
Objective Irisin is a myokine that greatly affects energy expenditure and systemic metabolism. While thyroid hormone is likely associated with irisin, a direct relationship remains to be fully elucidated.
Ning Yang, Heng Zhang, Xia Gao, Li Miao, Zhi Yao, Yuan Xu, Guang Wang   +6 more
doaj   +1 more source

Irisin promotes fracture healing by improving osteogenesis and angiogenesis

Journal of Orthopaedic Translation, 2022
Background: Osteogenesis and angiogenesis are important for bone fracture healing. Irisin is a muscle-derived monokine that is associated with bone formation.
Tianyou Kan, Zihao He, Jingke Du, Mingming Xu, Junqi Cui, Xuequan Han, Dake Tong, Hanjun Li, Mengning Yan, Zhifeng Yu   +9 more
doaj   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Engineered long-acting Irisin-albumin binding domain fusion protein for enhanced anti-inflammatory efficacy in lipopolysaccharide-induced systemic inflammation

Communications Biology
Irisin is a peptide hormone with notable anti-inflammatory and metabolic regulatory effects but has limited clinical utility due to its extremely short plasma half-life (< 1 h).
Jicun Zhu, Yujie Zhang, Xinwei Wang, Lei Peng, Xiaojia Ma, Zan Qiu, Zirui Kang, Fangyuan Zheng, Xiaoyu Zhang, Mengyuan Song, Jia Du, Yuan Shi, Lie Yu, Chenxi Gu, Jianxiang Shi   +14 more
doaj   +1 more source