Results 31 to 40 of about 18,190 (273)

Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer [PDF]

, 2019
Background. Fibronectin type III domain-containing (FNDC) proteins fulfill manifold functions in tissue development and regulation of cellular metabolism.
Adler, Andreas, Aigner, Felix, Becker, Olaf, Biebl, Matthias, Bosma, Madeleen, Pratschke, Johann, Quint, Janina, Spitz, Wolfgang, Stockmann, Martin, Veltzke-Schlieker, Wilfried, Weiss, Sascha, Wizenty, Jonas, Wuensch, Tilo   +12 more
core   +2 more sources

Irisin deficiency disturbs bone metabolism [PDF]

Journal of Cellular Physiology, 2020
Abstract Balancing the process of bone formation and resorption is important in the maintenance of healthy bone. Therefore, the discovery of novel factors that can regulate bone metabolism remains needed. Irisin is a newly identified hormone‐like peptide. Recent studies have reported the involvement of irisin in many physiological and
Xiaofang Zhu, Xiangfen Li, Xiaoxuan Wang, Ting Chen, Fengjuan Tao, Chuanju Liu, Qisheng Tu, Guofang Shen, Jake J. Chen   +8 more
openaire   +2 more sources

Exploring the role of esketamine in alleviating depressive symptoms in mice via the PGC-1α/irisin/ERK1/2 signaling pathway

Scientific Reports, 2023
Esketamine provides an immediate and noticeable antidepressant effect, although the underlying molecular processes are yet unclear. Irisin induced by aerobic exercise has been implicated in the alleviation of depressive symptoms, whether irisin ...
Na Hu, Xuemei Chen, Chengchuan Chen, Xing Liu, Peng Yi, Tianhao Xu, Jing Jia, Jianguo Feng, Chunxiang Zhang, Xiaobin Wang   +9 more
doaj   +1 more source

Irisin treatment improves healing of dystrophic skeletal muscle [PDF]

, 2017
Background: Irisin is an exercise induced myokine that is shown to promote browning of adipose tissue and hence, increase energy expenditure. Furthermore, our unpublished results indicate that Irisin improves myogenic differentiation and induces skeletal
Ge, Xiaojia, Kambadur, Ravi, McFarlane, Craig, Reza, Musarrat Maisha, Sharma, Mridula, Sim, Chu Ming, Subramaniyam, Nathiya   +6 more
core   +2 more sources

Irisin Exerts Inhibitory Effect on Adipogenesis Through Regulation of Wnt Signaling

Frontiers in Physiology, 2019
Irisin is an exercise-induced myokine known to induce adipocyte browning through induction of uncoupling protein 1. Recent studies have reported that irisin is also an adipokine.
Eun Bi Ma, Namood E. Sahar, Moonsup Jeong, Joo Young Huh   +3 more
doaj   +1 more source

Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts. [PDF]

PLoS ONE, 2015
Exercise offers short-term and long-term health benefits, including an increased metabolic rate and energy expenditure in myocardium. The newly-discovered exercise-induced myokine, irisin, stimulates conversion of white into brown adipocytes as well as ...
Chao Xie, Yuan Zhang, Tran D N Tran, Hai Wang, Shiwu Li, Eva Vertes George, Haoyang Zhuang, Peilan Zhang, Avi Kandel, Yimu Lai, Dongqi Tang, Westley H Reeves, Henrique Cheng, Yousong Ding, Li-Jun Yang   +14 more
doaj   +1 more source

FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle [PDF]

, 2016
[Abstract] Irisin is processed from fibronectin type III domain-containing protein 5 (FNDC5). However, a controversy exists concerning irisin origin, regulation and function.
Cordido, Fernando, Juiz-Valiña, Paula, Pena-Bello, Lara, Sangiao-Alvarellos, Susana, Varela-Rodríguez, Bárbara María, Vidal Bretal, Beatriz   +5 more
core   +2 more sources

Serum irisin levels are decreased in patients with sepsis, and exogenous irisin suppresses ferroptosis in the liver of septic mice

Clinical and Translational Medicine, 2020
Background Sepsis remains a major health issue without an effective therapy. Ferroptosis, an iron‐dependent programmed cell death, has been proposed to be related to the pathogenesis of sepsis.
Shasha Wei, Jianbin Bi, Lifei Yang, Jia Zhang, Yafeng Wan, Xue Chen, Yawen Wang, Zheng Wu, Yi Lv, Rongqian Wu   +9 more
doaj   +1 more source

Irisin, Energy Homeostasis and Male Reproduction [PDF]

Frontiers in Physiology, 2021
Irisin is a novel skeletal muscle- and adipose tissue-secreted peptide. It is conventionally regarded as an adipomyokine and is a cleaved fragment of Fibronectin type III domain-containing protein 5 (FNDC5). It is involved in the browning of white adipose tissue, glucose tolerance, and reversing of metabolic disruptions.
Pallav Sengupta, Sulagna Dutta, Ivan Rolland Karkada, Roland Eghoghosoa Akhigbe, Roland Eghoghosoa Akhigbe, Suresh V. Chinni   +5 more
openaire   +3 more sources

Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis

Frontiers in Pharmacology, 2019
ObjectiveThe aim of this study was to investigate whether the nuclear receptor farnesoid X receptor (FXR) could regulate FNDC5/Irisin expression and the role of Irisin in hyperlipidemia and atherosclerosis in ApoE-/- mice.Methods and ResultsWe treated ...
Hong Li, Hong Li, Jing Shen, Jing Shen, Tong Wu, Tong Wu, Jiangying Kuang, Jiangying Kuang, Qinhui Liu, Shihai Cheng, Shihai Cheng, Shiyun Pu, Shiyun Pu, Lei Chen, Lei Chen, Rui Li, Rui Li, Yanping Li, Yanping Li, Min Zou, Zhiyong Zhang, Wei Jiang, Aijuan Qu, Jinhan He, Jinhan He   +24 more
doaj   +1 more source