Results 31 to 40 of about 7,364 (142)

Irisin inhibits pancreatic cancer cell growth via the AMPK-mTOR pathway

Scientific Reports, 2018
Irisin, a recently identified myokine that is released from skeletal muscle following exercise, regulates body weight and influences various metabolic diseases such as obesity and diabetes.
Jiayu Liu, Nannan Song, Yibing Huang, Yuxin Chen   +3 more
doaj   +1 more source

Serum irisin levels and its association with blood glucose and insulin indices in diagnosing insulin resistance in adolescents with polycystic ovarian syndrome

Journal of Human Reproductive Sciences, 2021
Context: Irisin, a new myokine, has been found to be a biological marker of insulin resistance (IR). There is conflicting evidence on serum irisin level in adult women with polycystic ovarian syndrome (PCOS), and data are lacking in adolescents with PCOS.
Bhawina Sharan, Haritha Sagili, Sadish Kumar Kamalanathan, Subitha Lakshminarayanan   +3 more
doaj   +1 more source

Biomarkers of Sarcopenia: Current Status and Future Perspectives

AGING MEDICINE, EarlyView.
In this review, we summarize the various biomarkers discovered in recent years, including biochemical, imaging, and physical testing markers. We analyze their advantages and disadvantages and propose potential ways to improve the diagnostic accuracy of biomarkers, as well as future research directions.
Bijin Luo, Wenhan Li, Yi Zhang, Mengchen Liu, Kemeng Zhang, Sui Huang, Ping He   +6 more
wiley   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Serum Irisin level is associated with fall risk, muscle strength, and cortical porosity in postmenopausal women

Frontiers in Endocrinology, 2023
BackgroundIrisin plays a role in bone-muscle crosstalk, but the relationship between the serum irisin level and bone microarchitecture remains unknown.ObjectiveThis study aimed to investigate the relationships between serum irisin level and fall risk ...
Hanting Liang, Wenting Qi, Ruizhi Jiajue, Yue Chi, Wei Liu, Ou Wang, Mei Li, Xiaoping Xing, Wei Yu, Yan Jiang, Weibo Xia   +10 more
doaj   +1 more source

The impact of exercise on cognitive function and brain health across the lifespan: A systematic review

Ibrain, EarlyView.
This systematic review of 37 studies demonstrates that aerobic, resistance, and combined exercise enhance cognitive function and brain health across all ages. Exercise promotes neuroplasticity, upregulates brain‐derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF), and mitigates age‐related cognitive decline, establishing ...
Issam AbuQeis, Abeer Teeti, Amro Titi
wiley   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Irisin reduces senile osteoporosis by inducing osteocyte mitophagy through Ampk activation

iScience
Summary: Irisin, an exercise-induced myokine, is known to be able to regulate bone metabolism. However, the underlying mechanisms regarding the effects of irisin on senile osteoporosis have not been fully elucidated. Here, we demonstrated that irisin can
Honghan Li, Deqing Luo, Wei Xie, Wenbin Ye, Jinlong Chen, Paolo Alberton, Mingzhu Zhang, Eryou Feng, Denitsa Docheva, Dasheng Lin   +9 more
doaj   +1 more source

Mechanical Stimulation Protects Against Chondrocyte Pyroptosis Through Irisin-Induced Suppression of PI3K/Akt/NF-κB Signal Pathway in Osteoarthritis

Frontiers in Cell and Developmental Biology, 2022
Irisin, a myokine secreted by muscle during physical exercise, is known to have biological activities in different cell types. Chondrocyte inflammation and pyroptosis have been shown to play important roles in osteoarthritis (OA).
Shuangshuo Jia, Yue Yang, Yishu Bai, Yingliang Wei, He Zhang, Yicheng Tian, Jiabao Liu, Lunhao Bai   +7 more
doaj   +1 more source

Exercise, exerkines, and muscle–brain crosstalk in Parkinson's disease

Neuroprotection, EarlyView.
Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor and non‐motor symptoms, driven by dopaminergic loss and α‐synuclein accumulation. Beyond neurodegeneration, growing evidence highlights skeletal muscle health as a key determinant of prognosis, with sarcopenia and frailty contributing to greater disability, fall ...
Salomón Páez‐García, Edgar Alvarado, Alejandro Cuevas, Laura Valverde, Eduardo Salinas, Kevin O'Hara‐Veintimilla, María Cruz Rodríguez‐Oroz, Miguel Germán Borda   +7 more
wiley   +1 more source