Results 21 to 30 of about 4,586 (139)

Determination of Irisin, Body Mass Index, and Other Biochemical Parameters in a Sample of Iraqi Type II Diabetic Patients

Journal of Techniques, 2022
Evidence suggests that Irisin, a peptide hormone, may play a role in lipid metabolism, insulin resistance, and obesity. On the other hand, its role in type 2 diabetic Mellitus [T2DM] in humans is uncertain.
Takwa Al Koloob Ali Chachan, Huda Farhan, Shatha Hamed   +2 more
doaj   +1 more source

Irisin – a myth rather than an exercise-inducible myokine [PDF]

, 2015
The myokine irisin is supposed to be cleaved from a transmembrane precursor, FNDC5 (fibronectin type III domain containing 5), and to mediate beneficial effects of exercise on human metabolism. However, evidence for irisin circulating in blood is largely
Thiede, Bernd, Schering, Lisa, Thomas, Selina, Holen, T, Lee, Sindre, Ohashi, T, Maak, Steffen, Erickson, HP, Norheim, F, Drevon, CA, Maak, S, Brenmoehl, Julia, Norheim, Frode, Albrecht, E, Thomas, S, Brenmoehl, J, Schering, L, Ohashi, Tomoo, Thiede, B, Albrecht, Elke, Holen, Torgeir, Drevon, Christian A., Erickson, Harold P., Lee, S   +23 more
core   +2 more sources

Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis

Frontiers in Pharmacology, 2019
ObjectiveThe aim of this study was to investigate whether the nuclear receptor farnesoid X receptor (FXR) could regulate FNDC5/Irisin expression and the role of Irisin in hyperlipidemia and atherosclerosis in ApoE-/- mice.Methods and ResultsWe treated ...
Hong Li, Hong Li, Jing Shen, Jing Shen, Tong Wu, Tong Wu, Jiangying Kuang, Jiangying Kuang, Qinhui Liu, Shihai Cheng, Shihai Cheng, Shiyun Pu, Shiyun Pu, Lei Chen, Lei Chen, Rui Li, Rui Li, Yanping Li, Yanping Li, Min Zou, Zhiyong Zhang, Wei Jiang, Aijuan Qu, Jinhan He, Jinhan He   +24 more
doaj   +1 more source

Irisin Prevents Disuse-Induced Osteocyte Apoptosis [PDF]

, 2020
Previous results showed that intermittently administered irisin improves bone mass in normal mice and prevents the development of disuse-induced osteoporosis and muscular atrophy in hindlimb-suspended mice, a murine model able to mimic the absence of ...
Lippo L., Brunetti G., Errede M., Colucci S., Grano M. E, Passeri G., Sanesi L., Grano M., Storlino G., Colaianni G., Lippo L. a, Sanesi L   +11 more
core   +1 more source

Habitual physical activity is associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2

, 2015
Irisin, a novel myokine, has been shown to increase following vigorous exercise, with studies suggesting that it mediates some of the beneficial effects of exercise.
Amer, O.E, Alokail, M.S, Rahman, S, Chrousos, G.P, Alfawaz, H, Piya, M.K, Tripathi, G, Al‐Daghri, N.M, Al‐Attas, O.S, McTernan, P.G, Sabico, S.   +10 more
core   +2 more sources

Salivary and serum irisin in healthy adults before and after exercise

European Journal of Translational Myology, 2023
Irisin is an exercise-induced cytokine mainly secreted by myocytes. Circulating level of irisin can increase in response to acute exercise, promoting pleiotropic effects on health.
Sara Missaglia, Ester Tommasini, Paola Vago, Claudio Pecci, Christel Galvani, Andrea Silvestrini, Alvaro Mordente, Daniela Tavian   +7 more
doaj   +1 more source

Maternal inheritance of circulating irisin in humans

, 2014
The recently discovered myokine irisin has been implicated in several observational studies as a potential therapeutic target for obesity-related diseases. However, no information is available as to the heritability of this hormone.
Alnaami, AM, Amer, O.E, Piya, Milan K. (R19111), Vinodson, B., Sabico,S., Chrousos, GP, Al-Daghri, N., Al-Attas, O., Tripathi, G, Al-Attas, Omar S., Amer, O.E., Al-Daghri, Nasser M., Alnaami, A.M, Alnaami, A., McTernan, Philip G., Al-Attas, O.S, Sabico, S, Amer, OE, Piya, Milan K., Tripathi, Gyanendra, Alokail, M.S, McTernan, P. G., Piya, M.K., Alokail, M., Alkharfy, K.M., Al-Daghri, NM, Vinodson, Benjamin, Al-Attas, O.S., Alkharfy, KM, Alkharfy, Khalid M., Al-Daghri, N.M., Chrousos, G.P., Alnaami, A.M., Piya, MK, Alkharfy, K.M, Amer, O., Sabico, Shaun, Chrousos, G., McTernan, PG, Alokail, MS, Amer, Osama E., Alokail, Majed S., Alokail, M.S., McTernan, P., Alkharfy, K., Alnaami, Abdullah M., Tripathi, G., Al-Attas, OS, Piya, M., Yousef, M, Chrousos, George P., Sabico, S., Vinodson, B, Al-Daghri, N.M, McTernan, P.G., Yousef, Mansour, Yousef, M.   +56 more
core   +1 more source

Relationship between Irisin Concentration and Serum Cytokines in Mother and Newborn. [PDF]

PLoS ONE, 2016
Irisin is considered to be a myokine and adipokine that may also participate in reproductive functions, as it increases significantly throughout pregnancy.
Maria Hernandez-Trejo, Gerardo Garcia-Rivas, Alejandro Torres-Quintanilla, Estibalitz Laresgoiti-Servitje   +3 more
doaj   +1 more source

Serum irisin levels in women with polycystic ovary syndrome: a cross-sectional case-control study [PDF]

São Paulo Medical Journal
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine–metabolic disorder. Irisin is an exercise-related myokine involved in energy homeostasis; however, prior studies have reported inconsistent associations between irisin and PCOS ...
Atahan Toyran, Yagmur Minareci, Cavidan Gulerman   +2 more
doaj   +2 more sources

Irisin inhibits pancreatic cancer cell growth via the AMPK-mTOR pathway

Scientific Reports, 2018
Irisin, a recently identified myokine that is released from skeletal muscle following exercise, regulates body weight and influences various metabolic diseases such as obesity and diabetes.
Jiayu Liu, Nannan Song, Yibing Huang, Yuxin Chen   +3 more
doaj   +1 more source