Results 21 to 30 of about 7,364 (142)

Role of irisin in Chinese patients with hypothyroidism: an interventional study

Journal of International Medical Research, 2019
Objective Irisin is a myokine that greatly affects energy expenditure and systemic metabolism. While thyroid hormone is likely associated with irisin, a direct relationship remains to be fully elucidated.
Ning Yang, Heng Zhang, Xia Gao, Li Miao, Zhi Yao, Yuan Xu, Guang Wang   +6 more
doaj   +1 more source

Circulating irisin levels are positively associated with metabolic risk factors in sedentary subjects. [PDF]

PLoS ONE, 2015
A physically active life-style plays an independent role in the protection against type 2 diabetes and cardiovascular diseases. Irisin, a novel exercise-induced myokine, activates thermogenesis in rodents through increasing beige fat cells abundance ...
María Moreno, José María Moreno-Navarrete, Marta Serrano, Francisco Ortega, Elías Delgado, Cecilia Sanchez-Ragnarsson, Sergio Valdés, Patricia Botas, Wifredo Ricart, José Manuel Fernández-Real   +9 more
doaj   +1 more source

Expression, purification and biological characterisation of recombinant human irisin (12.5 kDa)

Journal of Genetic Engineering and Biotechnology, 2018
Fibronectin type III domain containing 5 (FNDC5) is a transmembrane protein. Upon cleavage, it yields a peptide called irisin that is supposedly bind to an unknown receptor and facilitates browning of white adipose tissue (WAT).
Kalpana Panati, Venkata Ramireddy Narala, Vydyanath R. Narasimha, Madhavi Derangula, Venkat R.R. Arva Tatireddigari, Suneetha Yeguvapalli   +5 more
doaj   +1 more source

Salivary and serum irisin in healthy adults before and after exercise

European Journal of Translational Myology, 2023
Irisin is an exercise-induced cytokine mainly secreted by myocytes. Circulating level of irisin can increase in response to acute exercise, promoting pleiotropic effects on health.
Sara Missaglia, Ester Tommasini, Paola Vago, Claudio Pecci, Christel Galvani, Andrea Silvestrini, Alvaro Mordente, Daniela Tavian   +7 more
doaj   +1 more source

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

eLife, 2020
Irisin, a skeletal-muscle secreted myokine, facilitates muscle-bone crosstalk and skeletal remodeling in part by its action on osteoblasts and osteocytes. In this study, we investigated whether irisin directly regulates osteoclasts.
Eben G Estell, Phuong T Le, Yosta Vegting, Hyeonwoo Kim, Christiane Wrann, Mary L Bouxsein, Kenichi Nagano, Roland Baron, Bruce M Spiegelman, Clifford J Rosen   +9 more
doaj   +1 more source

Determination of Irisin, Body Mass Index, and Other Biochemical Parameters in a Sample of Iraqi Type II Diabetic Patients

Journal of Techniques, 2022
Evidence suggests that Irisin, a peptide hormone, may play a role in lipid metabolism, insulin resistance, and obesity. On the other hand, its role in type 2 diabetic Mellitus [T2DM] in humans is uncertain.
Takwa Al Koloob Ali Chachan, Huda Farhan, Shatha Hamed   +2 more
doaj   +1 more source

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Relationship between Irisin Concentration and Serum Cytokines in Mother and Newborn. [PDF]

PLoS ONE, 2016
Irisin is considered to be a myokine and adipokine that may also participate in reproductive functions, as it increases significantly throughout pregnancy.
Maria Hernandez-Trejo, Gerardo Garcia-Rivas, Alejandro Torres-Quintanilla, Estibalitz Laresgoiti-Servitje   +3 more
doaj   +1 more source

The Effect of Resistance Training and Ursolic Acid on the PI3K‐AKT‐mTOR Pathway in Aged Diabetic Rats: A Comparative Study

AGING MEDICINE, EarlyView.
Resistance training combined with ursolic acid supplementation restores anabolic signaling (PI3K/mTORC1) suppressed by diabetes, helping preserve muscle mass. This strategy may offer a potential therapeutic approach to combat muscle atrophy and support healthy aging in diabetic conditions.
Ashkan Sadeghi, Safoura Alizade, Mohammad Faramarzi, Mostafa Rahimi, Rohit Kumar Thapa   +4 more
wiley   +1 more source

Engineered long-acting Irisin-albumin binding domain fusion protein for enhanced anti-inflammatory efficacy in lipopolysaccharide-induced systemic inflammation

Communications Biology
Irisin is a peptide hormone with notable anti-inflammatory and metabolic regulatory effects but has limited clinical utility due to its extremely short plasma half-life (< 1 h).
Jicun Zhu, Yujie Zhang, Xinwei Wang, Lei Peng, Xiaojia Ma, Zan Qiu, Zirui Kang, Fangyuan Zheng, Xiaoyu Zhang, Mengyuan Song, Jia Du, Yuan Shi, Lie Yu, Chenxi Gu, Jianxiang Shi   +14 more
doaj   +1 more source