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Progress and Challenges in the Biology of FNDC5 and Irisin [PDF]

Endocrine Reviews, 2021
In 2002, a transmembrane protein—now known as FNDC5—was discovered and shown to be expressed in skeletal muscle, heart, and brain. It was virtually ignored for 10 years, until a study in 2012 proposed that, in response to exercise, the ectodomain of ...
Steffen Maak, Frode Norheim, Christian A Drevon   +2 more
exaly   +6 more sources

Exercise-Induced FNDC5/Irisin Ameliorates Cognitive Impairment in Aged Mice, Associated with Antioxidant and Neurotrophic Responses [PDF]

Antioxidants
Aging contributes to neurodegeneration, predominantly characterized by increased oxidative stress, which leads to neurodegenerative changes and cognitive decline. This cognitive impairment is often associated with neuroinflammation, oxidative stress, and
Jae Min Lee, Tae Hyeok Sim, So Hee Kim, You Jung Choi, Joo Hee Lee, Seung Geun Yeo, Youn-Jung Kim   +6 more
doaj   +3 more sources

FNDC5/irisin-enriched sEVs conjugated with bone-targeting aptamer alleviate osteoporosis: a potential alternative to exercise [PDF]

Journal of Nanobiotechnology
Exercise maintains bone health and produces protective effects on bone loss. In this study, we investigated the potential protective effects of circulating small extracellular vesicles (sEVs) generated under endurance exercise training (Exe-sEVs) on ...
Min-Zhi Mao, Ming-Hui Zheng, Bei Guo, Ya-Li Ling, Xiao Lin, Fu-Xing-Zi Li, Su-Kang Shan, De-Xing Dai, Lei Qiu, Xue-Yang Cai, Ya Ding, Ying-Ying Gu, Qi-Rong Deng, Zhi-Ang Zhou, Li-Min Lei, Cheng Tao, Rong-Rong Cui, Feng Wu, Fei Zhang, Bo Wu, Le-Le Liao, Chang-Ming Tan, Xiao-Bo Liao, Ling-Qing Yuan, Feng Xu   +24 more
doaj   +3 more sources

Identification of candidate nsSNPs of the human FNDC5 gene and their structural and functional consequences using in silico analysis

Scientific Reports
Fibronectin type-III domain containing protein-5 (FNDC5), predominantly expressed in skeletal muscles, encodes FNDC5 transmembrane-protein. A segment of this protein is cleaved and secreted into blood as irisin, which promotes browning of white adipose ...
Sadaf Majeed, Hira Moin, Maaz Waseem, Zoya Khalid, Sumra Wajid Abbasi, Kashaf Rasool   +5 more
doaj   +2 more sources

FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms

Redox Biology
Cardiotoxicity remains a major limiting factor in the clinical implementation of anthracycline chemotherapy. Though the etiology of doxorubicin-dependent heart damage has yet to be fully elucidated, the ability of doxorubicin to damage DNA and trigger ...
Manish Kumar, Abhishek Singh Sengar, Anushree Lye, Pranesh Kumar, Sukhes Mukherjee, Dinesh Kumar, Priyadip Das, Suvro Chatterjee, Adele Stewart, Biswanath Maity   +9 more
doaj   +2 more sources

FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control

Cell Death and Disease
Mitochondrial dysfunction and oxidative stress are important mechanisms for secondary injury after traumatic brain injury (TBI), which result in progressive pathophysiological exacerbation.
Yufeng Ge, Xun Wu, Yaning Cai, Qing Hu, Jin Wang, Shenghao Zhang, Baocheng Zhao, Wenxing Cui, Yang Wu, Qiang Wang, Tian Feng, Haixiao Liu, Yan Qu, Shunnan Ge   +13 more
doaj   +2 more sources

Fndc5 modification optimizes the therapeutic effect of rat MSCs on sepsis-induced ALI/ARDS via activating the PI3K/AKT signaling pathway [PDF]

Stem Cell Research & Therapy
Background Acute lung injury/Acute respiratory distress syndrome (ALI/ARDS) is a life-threatening inflammatory lung disorder characterized by high mortality rates and a lack of effective treatment options.
Yuling Luo, Minhua Li, Shan Lin, Zheng Gong, Sumei Wang, Ziqing Zhou, Shiyue Li   +6 more
doaj   +2 more sources

Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review [version 2; referees: 2 approved] [PDF]

F1000Research, 2017
Background: Exercise may activate a brown adipose-like phenotype in white adipose tissue. The aim of this systematic review was to identify the effects of physical activity on the link between peroxisome proliferator-activated receptor gamma coactivator ...
Petros C. Dinas, Ian M. Lahart, James A. Timmons, Per-Arne Svensson, Yiannis Koutedakis, Andreas D. Flouris, George S. Metsios   +6 more
doaj   +4 more sources

Impact of Exercise Intensity on Cerebral BDNF Levels: Role of FNDC5/Irisin

International Journal of Molecular Sciences
The positive effects of physical exercise (EX) are well known to be mediated by cerebral BDNF (brain-derived neurotrophic factor), a neurotrophin involved in learning and memory, the expression of which could be induced by circulating irisin, a peptide ...
Aurore Quirie
exaly   +2 more sources

Targeting the PINK1/Parkin-FNDC5 pathway: a novel mechanism of icariin in regulating muscle-bone metabolic coupling in osteosarcopenia [PDF]

Journal of Translational Medicine
Background Osteosarcopenia (OS) significantly elevates fracture risk in the elderly due to concurrent skeletal and muscular metabolic decline. Mitochondrial autophagy dysregulation is a significant mechanism driving myoskeletal metabolic imbalance, and ...
Mengyan Zhao, Fei Yuan, Chaoyang Liu, Tao Guo   +3 more
doaj   +2 more sources