FNDC5/Irisin: Physiology and Pathophysiology [PDF]
Molecules, 2022 A sedentary lifestyle or lack of physical activity increases the risk of different diseases, including obesity, diabetes, heart diseases, certain types of cancers, and some neurological diseases.
Rashid Waseem +9 more
semanticscholar +4 more sources
Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor? [PDF]
Adipocyte, 2013 FNDC5 (fibronectin domain-containing [protein] 5) was initially discovered and characterized by two groups in 2002. In 2011 FNDC5 burst into prominence as the parent of irisin, a small protein containing the fibronectin type III domain.
Erickson, HP
core +4 more sources
FNDC5/irisin is not only a myokine but also an adipokine. [PDF]
PLoS ONE, 2013 Exercise provides clear beneficial effects for the prevention of numerous diseases. However, many of the molecular events responsible for the curative and protective role of exercise remain elusive.
Arturo Roca-Rivada +8 more
doaj +5 more sources
Gene Location, Expression, and Function of FNDC5 in Meishan Pigs [PDF]
Scientific Reports, 2017 Irisin is a new muscular regulatory factor that is generated by the cleavage of its precursor protein fibronectin type III domain-containing protein 5 (FNDC5).
Chunbo Cai +9 more
doaj +3 more sources
The Role of FNDC5/Irisin in Cardiovascular Disease
CellsDisorders of cardiomyocyte metabolism play a crucial role in many cardiovascular diseases, such as myocardial infarction, heart failure and ischemia–reperfusion injury.
Maciej Grzeszczuk +2 more
semanticscholar +4 more sources
FNDC5 and ACOX1 as Biomarkers of Peroxisomal Activity with Contrast Outcomes in Colon Adenocarcinoma. [PDF]
Biol Proced OnlineColorectal cancer progression and immune evasion are closely linked to mitochondrial and peroxisomal metabolic reprogramming, yet the role of peroxisomes remains underexplored.
Hepei Y +7 more
europepmc +2 more sources
CircRNA AFF4 induced by KDM1A promotes osteogenic differentiation through FNDC5/Irisin pathway
Molecular Medicine, 2022 Background Circular RNA (circ) AFF4 was documented to regulate osteogenesis but the underlying mechanism remains to be elucidated. The preliminary study showed that circ_AFF4 may promote osteogenesis via FNDC5/Irisin.
Ansong Liu +8 more
doaj +3 more sources
PGC-1α promotes the survival of newborn neurons within AD hippocampus through activation of the FNDC5/BDNF/TrkB signaling pathway. [PDF]
Front Mol NeurosciBackground The learning and memory impairments observed in Alzheimer’s disease (AD) are strongly associated with impaired neurogenesis in the hippocampal region.
Wang YJ +10 more
europepmc +2 more sources
Potential role of FNDC5 in exercise-induced improvement of cognitive function. [PDF]
J Zhejiang Univ Sci BCognitive dysfunction often occurs in Alzheimer’s disease, Parkinson’s disease, cerebrovascular disease, or other neurodegenerative diseases, and can significantly impact the life quality of patients and create serious social, psychological, and economic
Zhao R, Zhou X, Wang D, Tang H, Ni G.
europepmc +2 more sources
BMAL1/PGC1α4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exercise
Journal of Sport and Health ScienceBackground: Resistance exercise leads to improved muscle function and metabolic homeostasis. Yet how circadian rhythm impacts exercise outcomes and its molecular transduction remains elusive.
Mingwei Guo +36 more
doaj +2 more sources