Results 31 to 40 of about 7,212 (245)

GLP-1 Induces the Expression of FNDC5 Derivatives That Execute Lipolytic Actions

Frontiers in Cell and Developmental Biology, 2021
Multiple GLP-1-derived therapeutics are clinically used to treat type 2 diabetes and obesity. However, the underlying mechanism of how these drugs regulate the body weight of obese patients remains incompletely understood.
Hui Li, Hui Li, William Donelan, Fang Wang, Peilan Zhang, Lijun Yang, Yousong Ding, Dongqi Tang, Shiwu Li   +8 more
doaj   +1 more source

Low-intensity pulsed ultrasound triggers a beneficial neuromodulation in dementia mice with chronic cerebral hypoperfusion via activation of hippocampal Fndc5/irisin signaling

Journal of Translational Medicine, 2023
Background Exercise-related signaling Fndc5/irisin expresses in brain and acts as a crucial regulator of cognitive function, but its detailed roles in vascular dementia (VaD) are still unclear.
Degang Song, Xiaomin Chen, Na Zhou, Yi Yuan, Shuo Geng, Cong Zhang, Zhe Zhao, Xingran Wang, Xinran Bao, Xifa Lan, Xiangjian Zhang   +10 more
doaj   +1 more source

FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells

Frontiers in Oncology, 2022
In this study, we aimed to reveal the resistance mechanism of hepatocellular carcinoma (HCC) cells to sorafenib by exploring the effect of FNDC5 on sorafenib-induced ferroptosis in HCC cells.
Huayuan Liu, Lei Zhao, Mengya Wang, Kexin Yang, Zhipeng Jin, Chengjian Zhao, Guangjun Shi   +6 more
doaj   +1 more source

FNDC5 inhibits autophagy of bone marrow mesenchymal stem cells and promotes their survival after transplantation by downregulating Sp1

Cell Death Discovery, 2023
Regenerative therapy based on mesenchymal stem cells (MSCs) has great promise to achieve functional recovery in cerebral infarction patients. However, the survival rate of transplanted MSCs is extremely low because of destructive autophagy caused by the ...
Huan Wei, Shuaiye Liu, Tingting Wang, Yanping Li, Kangmei Liu, Qunying Guo, Ling Li   +6 more
doaj   +1 more source

Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice

Biomolecules, 2021
Irisin is an exercise-induced myokine, suggested to exert beneficial effects on metabolism. However, the studies on the regulation of irisin secretion and the expression of its precursor FNDC5 have shown conflicting data. The discrepancies among previous
Songling Jiang, Lingjuan Piao, Eun Bi Ma, Hunjoo Ha, Joo Young Huh   +4 more
doaj   +1 more source

FNDC5/Irisin: A New Protagonist in Acute Brain Injury [PDF]

Stem Cells and Development, 2020
Acute brain injury (ABI), including stroke and traumatic brain injury, which accounts for a heavy burden of morbidity and mortality, results in a great loss of productive life and serious health problem worldwide. To improve patients' survival and ameliorate their outcome, effective clinical treatment strategies and new therapeutic targets are urgently
Tianqi, Tu, Jianhua, Peng, Yong, Jiang
openaire   +2 more sources

FNDC5/irisin improves the therapeutic efficacy of bone marrow-derived mesenchymal stem cells for myocardial infarction

Stem Cell Research & Therapy, 2020
Background The beneficial functions of bone marrow mesenchymal stem cells (BM-MSCs) decline with decreased cell survival, limiting their therapeutic efficacy for myocardial infarction (MI).
Jingyu Deng, Ning Zhang, Yong Wang, Chao Yang, Yabin Wang, Chao Xin, Jinming Zhao, Zhitao Jin, Feng Cao, Zheng Zhang   +9 more
doaj   +1 more source

Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer [PDF]

, 2019
Background. Fibronectin type III domain-containing (FNDC) proteins fulfill manifold functions in tissue development and regulation of cellular metabolism.
Adler, Andreas, Aigner, Felix, Becker, Olaf, Biebl, Matthias, Bosma, Madeleen, Pratschke, Johann, Quint, Janina, Spitz, Wolfgang, Stockmann, Martin, Veltzke-Schlieker, Wilfried, Weiss, Sascha, Wizenty, Jonas, Wuensch, Tilo   +12 more
core   +2 more sources

Glucocorticoid receptor positively regulates transcription of FNDC5 in the liver [PDF]

Scientific Reports, 2017
AbstractIrisin is secreted by skeletal muscle during exercise and influences energy and metabolic homeostasis. This hormone is a cleaved and secreted fragment of fibronectin type III domain-containing 5 (FNDC5). Elucidation of the FNDC5 gene regulation mechanism is necessary to clarify the function of irisin as a potential therapeutic target in human ...
Kim, Hyoung Kyu, Jeong, Yu Jeong, Song, In-Sung, Noh, Yeon Hee, Seo, Kyo Won, Kim, Min, Han, Jin   +6 more
openaire   +3 more sources

Irisin evokes bradycardia by activating cardiac-projecting neurons of nucleus ambiguus. [PDF]

, 2015
Irisin is a newly identified hormone induced in muscle and adipose tissues by physical activity. This protein and its encoding gene have been identified in the brain; in addition, the precursor for irisin, FNDC5, can cross the blood-brain barrier.
Brailoiu, Eugen, Brailoiu, Gabriela Cristina, Deliu, Elena, Sporici, Romeo A   +3 more
core   +2 more sources