Results 51 to 60 of about 7,212 (245)

Prepontine non-giant neurons drive flexible escape behavior in zebrafish [PDF]

, 2019
Many species execute ballistic escape reactions to avoid imminent danger. Despite fast reaction times, responses are often highly regulated, reflecting a trade-off between costly motor actions and perceived threat level.
Bergeron, S., Briggman, K., Burgess, H., Marquart, G., Tabor, K.   +4 more
core   +2 more sources

Increased FNDC5/Irisin expression in human hepatocellular carcinoma

Peptides, 2017
The fibronectin type III domain containing 5 (FNDC5)/Irisin, a novel energy-regulating hormone, is associated with lipid and carbohydrate metabolism. It is produced in low amounts by normal hepatic tissue, while in human hepatocellular carcinoma (HCC), in which aberrant de novo lipogenesis (DNL) occurs, the hepatic expression of FNDC5/Irisin is still ...
Gaggini M, Cabiati M, Del Turco S, Navarra T, De Simone P, Filipponi F, Del Ry S, Gastaldelli A, Basta G   +8 more
openaire   +4 more sources

FNDC5 attenuates obesity-induced cardiac hypertrophy by inactivating JAK2/STAT3-associated inflammation and oxidative stress

Journal of Translational Medicine, 2019
Background Chronic low-grade inflammation and oxidative stress play important roles in the development of obesity-induced cardiac hypertrophy. Here, we investigated the role of Fibronectin type III domain containing 5 (FNDC5) in cardiac inflammation and ...
Zhi Geng, Wen-Yong Fan, Bing Zhou, Chao Ye, Ying Tong, Ye-Bo Zhou, Xiao-Qing Xiong   +6 more
doaj   +1 more source

Lack of Association Between FNDC5 Gene Polymorphisms, Serum Irisin Levels and Allergic Rhinitis

Acta Medica Alanya, 2023
Aim: Allergic rhinitis (AR) is an inflammatory nasal mucosa disease caused by type 1 immunoglobulin E-mediated reactions to allergen exposure. Irisin is a hormone released by skeletal muscles in response to exercise.
Hüseyin Günizi, Durkadın Demir Ekşi
doaj   +1 more source

Exosomes secreted by FNDC5-BMMSCs protect myocardial infarction by anti-inflammation and macrophage polarization via NF-κB signaling pathway and Nrf2/HO-1 axis

Stem Cell Research & Therapy, 2021
Background Exosomes are considered a substitute for stem cell-based therapy for myocardial infarction (MI). FNDC5, a transmembrane protein located in the cytoplasm, plays a crucial role in inflammation diseases and MI repair.
Hongjuan Ning, Haixu Chen, Jingyu Deng, Chun Xiao, Moyan Xu, Lina Shan, Chao Yang, Zheng Zhang   +7 more
doaj   +1 more source

Correlation between the muscle, blood and heart level of Irisin in exercise-trained rats with Nano selenium supplementation: A rat model of COPD [PDF]

Journal of Exercise & Organ Cross Talk, 2023
The aim of this study was to considering the correlation between the muscle fibronectin type III domain-containing protein 5 (FNDC5), blood and heart level of Irisin in exercise-trained rats with Nano selenium supplementation after intraperitoneal ...
Zohreh Fathi, Javad Raouf Sarshoori, Mohammad Reza Masjedi, Shadmehr Mirdar   +3 more
doaj   +1 more source

Irisin treatment improves healing of dystrophic skeletal muscle [PDF]

, 2017
Background: Irisin is an exercise induced myokine that is shown to promote browning of adipose tissue and hence, increase energy expenditure. Furthermore, our unpublished results indicate that Irisin improves myogenic differentiation and induces skeletal
Ge, Xiaojia, Kambadur, Ravi, McFarlane, Craig, Reza, Musarrat Maisha, Sharma, Mridula, Sim, Chu Ming, Subramaniyam, Nathiya   +6 more
core   +2 more sources

Effects of the FNDC5/Irisin on Elderly Dementia and Cognitive Impairment

Frontiers in Aging Neuroscience, 2022
Population aging is an inevitable problem nowadays, and the elderly are going through a lot of geriatric symptoms, especially cognitive impairment. Irisin, an exercise-stimulating cleaved product from transmembrane fibronectin type III domain-containing protein 5 (FNDC5), has been linked with favorable effects on many metabolic diseases.
Jin Peng, Jinhui Wu
openaire   +3 more sources

Exerkine FNDC5/irisin‐enriched exosomes promote proliferation and inhibit ferroptosis of osteoblasts through interaction with Caveolin‐1

Aging Cell
Postmenopausal osteoporosis is a prevalent metabolic bone disorder characterized by a decrease in bone mineral density and deterioration of bone microstructure. Despite the high prevalence of this disease, no effective treatment for osteoporosis has been
Lin Tao, Jinpeng Wang, Ke Wang, Qichang Liu, Hongyang Li, Site Xu, Chunjian Gu, Yue Zhu   +7 more
semanticscholar   +1 more source

Exercise-induced myokine FNDC5/irisin functions in cardiovascular protection and intracerebral retrieval of synaptic plasticity

Cell & Bioscience, 2019
Physical exercise is well known to benefit human health at every age. However, the exact mechanism through which physical exercise improves health remains unknown.
Xin Zhou, MengMeng Xu, Joseph L. Bryant, Jianjie Ma, Xuehong Xu   +4 more
doaj   +1 more source