Evidence against a beneficial effect of irisin in humans. [PDF]
PLoS ONE, 2013 Brown adipose tissue has gained interest as a potential target to treat obesity and metabolic diseases. Irisin is a newly identified hormone secreted from skeletal muscle enhancing browning of white fat cells, which improves systemic metabolism by ...
Silja Raschke +15 more
doaj +1 more source
Impacto de la vía no canónica de cortisol sobre la expresión de fndc5 en músculo esquelético de trucha arcoíris (Oncorhynchus mykiss) [PDF]
, 2019 Tesis (Ingeniero en Biotecnología)proyecto FONDAP INCAR 15110027 y FONDECYT 1171318Actualmente, Chile tiene un papel importante en la acuicultura mundial, el 70,1% de esta actividad corresponde a salmónidos donde trucha arcoíris (Oncorhynchus mykiss) se
Espinoza González, Carlos Agustín
core
Connecting rules from paired miRNA and mRNA expression data sets of HCV patients to detect both inverse and positive regulatory relationships [PDF]
, 2015 © 2015 Song et al.; licensee BioMed Central Ltd. Background: Intensive research based on the inverse expression relationship has been undertaken to discover the miRNA-mRNA regulatory modules involved in the infection of Hepatitis C virus (HCV), the ...
Li, J, Liu, Q, Liu, T, Song, R
core +3 more sources
Seven days of warm‐water immersion enhances resting irisin and BDNF, but not klotho, in older men
Experimental Physiology, EarlyView.Abstract We examined whether seven consecutive days of warm‐water immersion could elevate resting and exercise‐induced levels of brain‐derived neurotrophic factor (BDNF), irisin and klotho in older adults. These biomarkers support cognitive and metabolic health, but their levels decline with age.
Joel M Garrett +6 more
wiley +1 more source
Skeletal muscle AMPK is essential for the maintenance of FNDC5 expression [PDF]
Physiological Reports, 2015 Fibronectin type III domain-containing protein 5 (FNDC5) expression is controlled by the transcriptional co-activator, peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC1α). FNDC5 expression has been shown to be increased in muscle in response to endurance exercise in some but not all studies, therefore a greater understanding ...
Lally, JSV +5 more
openaire +4 more sources
Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis
Frontiers in Pharmacology, 2019 ObjectiveThe aim of this study was to investigate whether the nuclear receptor farnesoid X receptor (FXR) could regulate FNDC5/Irisin expression and the role of Irisin in hyperlipidemia and atherosclerosis in ApoE-/- mice.Methods and ResultsWe treated ...
Hong Li +24 more
doaj +1 more source
Aging Cell, Volume 25, Issue 5, May 2026.We provide the first human evidence that the exercise‐induced myokine irisin mediates the relationship between physical activity and hippocampal volume in older adults, with strongest effects in CA1, CA3 and CA4 subfields. These regions are critical for memory and particularly vulnerable to Alzheimer's disease.
Thomas Pace +5 more
wiley +1 more source
FNDC5 is produced in the stomach and associated to body composition [PDF]
Scientific Reports, 2016 AbstractThe fibronectin type III domain-containing protein 5 (FNDC5) discovered in 2002 has recently gained attention due to its potential role in protecting against obesity. In rat, no data exist regarding FNDC5 production and regulation in the stomach.
S. Barja-Fernández +9 more
openaire +3 more sources
Cellular Physiology and Biochemistry, 2018 Background/Aims: Fibronectin type III domain-containing protein 5 (FNDC5), also known as irisin, is a myokine secreted from muscle in response to exercise.
Xiu-ying Yang +5 more
doaj +1 more source
The alteration of irisin - brain-derived neurotrophic factor axis parallels severity of distress disorder in bronchial asthma patients [PDF]
, 2017 Distress disorder (a collective term for generalized anxiety disorder and major depressive disorder) is a well-known co-morbidity of bronchial asthma.
Fodor, Andrea +11 more
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