Results 91 to 100 of about 7,212 (245)

Dietary Bioactives and Physical Activity in the Regulation of Hippocampal Neurogenesis and Cognitive Decline

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Exercise and dietary polyphenols enhance hippocampal plasticity and cognitive function via complementary molecular mechanisms. Central pathways include BDNF signaling, inflammation control, and mitochondrial regulation. Although synergy is mainly supported by preclinical data, lifestyle‐based strategies show promise for brain health maintenance ...
Zhenyi Zhao, Sima‐sadat Sabihi
wiley   +1 more source

The effects of resistance training, testosterone and palm (Phoenix dactylifera L.) pollen extract on the expression of FNDC5 and IGF1 genes in brown adipose tissue in male rats [PDF]

مجله علوم پزشکی فیض (پیوسته), 2023
Background and Aim: The use of testosterone enanthate is popular among athletes, especially resistance sports. Considering the side effects of using testosterone enanthate, it seems necessary to find alternative methods.
Ali Arbati, Hasan Matinhomaee, Mohammad Ali Azarbayjani, Saleh Rahmati   +3 more
doaj  

LKB1–AMPK Signaling Pathway in Cardiovascular and Other Diseases

MedComm, Volume 7, Issue 3, March 2026.
The LKB1–AMPK pathway has a central regulatory role in various diseases. Dysfunction of this pathway can lead to pathological processes in cardiovascular diseases (atrial fibrillation, myocardial infarction, myocardial hypertrophy, atherosclerosis), metabolic diseases (diabetes and kidney disease), neurodegenerative diseases (Alzheimer's disease ...
Zhuo Chen, Qin Yang, Guo‐Wei He
wiley   +1 more source

Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF rats [PDF]

Metabolism, 2013
There is debate as to whether fibronectin type III domain containing 5 (FNDC5) and its protein product irisin are therapeutic targets for obesity-associated maladies. Thus, we sought to examine FNDC5 mRNA within skeletal muscle of obese/diabetic-prone Otsuka Long-Evans Tokushima Fatty (OLETF) rats versus lean/healthy Long Evans Tokushima Otsuka (LETO ...
Michael D, Roberts, David S, Bayless, Joseph M, Company, Nathan T, Jenkins, Jaume, Padilla, Thomas E, Childs, Jeffrey S, Martin, Vincent J, Dalbo, Frank W, Booth, R Scott, Rector, M Harold, Laughlin   +10 more
openaire   +2 more sources

Impact of combined ginsenoside‐MC1 and irisin on mitochondrial apoptosis in diabetic rats with hepatic reperfusion injury: Role of AMPK/JNK signalling

Experimental Physiology, Volume 111, Issue 3, Page 751-764, 1 March 2026.
Abstract Hepatic ischaemia–reperfusion (IR) injury is a serious clinical issue, especially in patients with type 2 diabetes mellitus (T2DM). As mitochondria play a critical role in the regulation of IR‐induced liver damage, mitochondria‐targeted treatment is of the utmost significance for improving outcomes.
Jie Lin, Lei Han, Zhigang Ma, Bo Yuan, Yabin Yu   +4 more
wiley   +1 more source

Integrative physiology of skeletal muscle for maintaining cognitive health

The Journal of Physiology, Volume 604, Issue 6, Page 2448-2457, 15 March 2026.
Abstract figure legend Maintenance of brain/cognitive health and function is increasingly appreciated to be a systemic challenge. In particular, skeletal muscle influences the brain through release of myokines in response to contraction, which influence the expression of brain‐derived neurotrophic factor (BDNF) in the brain, a vital player in the ...
Matthew H. Brisendine, Joshua C. Drake
wiley   +1 more source

Irisin/FNDC5--An updated review.

European review for medical and pharmacological sciences, 2016
The irisin, recently identified novel molecule, has been shown to be secreted from fibronectin type III domain containing 5 (FNDC5) of skeletal muscle by an unknown protease. It has been proposed that this molecule plays an important role in converting the white adipose tissue to brown adipose tissue and regulating the energy expenditure.
K, Panati, Y, Suneetha, V R, Narala
openaire   +1 more source

تأثیر دویدن روی نوارگردان با شدت کم بر بیان ژن های PGC-1α، FNDC5 و BDNF درهیپوکامپ موش های صحرایی نر [PDF]

مطالعات کاربردی علوم زیستی در ورزش, 2019
زمینه و هدف: مطالعات پیشین نشان داده­­ اند که عامل نوروتروفیک مشتق شده از مغز (BDNF) در القاء اثرات مفید فعالیت ورزشی بر مغز به ویژه هیپوکامپ نقش بسیار حیاتی دارد.
سید محمد علی عظیمی دخت, رضا قراخانلو, ناصر نقدی, داور خدادادی, علی اصغر زارع زاده مهریزی   +4 more
doaj   +1 more source

Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy [PDF]

, 2017
Exercise induces expression of the myokine irisin, which is known to promote browning of white adipose tissue and has been shown to mediate beneficial effects following exercise. Here we show that irisin induces expression of a number of pro-myogenic and
Ge, Xiaojia, Kambadur, Ravi, McFarlane, Craig, Reza, Musarrat Maisha, Sathiakumar, Durgalakshmi, Sharma, Mridula, Sim, Chu Ming, Subramaniyam, Nathiya   +7 more
core   +3 more sources

FNDC5/irisin ameliorates bone loss of type 1 diabetes by suppressing endoplasmic reticulum stress‑mediated ferroptosis

Journal of Orthopaedic Surgery and Research
Ferroptosis is known to play a crucial role in diabetic osteopathy. However, key genes and molecular mechanisms remain largely unclear. This study aimed to identify a crucial ferroptosis-related differentially expressed gene (FR-DEG) in diabetic ...
Qianqian Dong, Ziqi Han, Mingdong Gao, Limin Tian   +3 more
semanticscholar   +1 more source