Results 1 to 10 of about 7,364 (142)

Role of Irisin in Myocardial Infarction, Heart Failure, and Cardiac Hypertrophy

Cells, 2021
Irisin is a myokine derived from the cleavage of fibronectin type III domain-containing 5. Irisin regulates mitochondrial energy, glucose metabolism, fatty acid oxidation, and fat browning.
Chao-Yung Wang
exaly   +3 more sources

Serum irisin levels are decreased in patients with sepsis, and exogenous irisin suppresses ferroptosis in the liver of septic mice

Clinical and Translational Medicine, 2020
Background Sepsis remains a major health issue without an effective therapy. Ferroptosis, an iron‐dependent programmed cell death, has been proposed to be related to the pathogenesis of sepsis.
Jianbin Bi, Lifei Yang, Jia Zhang
exaly   +2 more sources

Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress

Redox Biology, 2019
Current management of liver ischemia-reperfusion (I/R) injury is mainly based on supportive care and no specific treatment is available. Irisin, a recently identified hormone, plays pivotal roles in energy expenditure and oxidative metabolism; however ...
Jianbin Bi, Jia Zhang, Yifan Ren
exaly   +3 more sources

Relationship between serum irisin level, all-cause mortality, and cardiovascular mortality in peritoneal dialysis patients

Kidney & Blood Pressure Research, 2023
Introduction: This study aimed to investigate the prospective role of serum irisin-a novel adipo-myokine-in all-cause mortality and cardiovascular (CV) mortality in patients on peritoneal dialysis (PD).
Sijia Zhou, Wen Tang, Xiaoxiao Wang, Qingfeng Han, Qiong Bai, Aihua Zhang   +5 more
doaj   +1 more source

The optimal therapeutic irisin dose intervention in animal model: A systematic review [PDF]

Veterinary World, 2020
Background and Aim: Irisin, a novel myocyte-secreted hormone, was proposed to mediate some of the beneficial effects of exercise such as browning of adipocytes, thermogenesis, and metabolic homeostasis.
Foad Alzoughool, Mohammad Borhan Al-Zghoul, Saad Al-Nassan, Lo'ai Alanagreh, Dana Mufleh, Manar Atoum   +5 more
doaj   +1 more source

Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis

Frontiers in Cell and Developmental Biology, 2021
To investigate the effects and mechanisms of irisin, a newly discovered myokine, in cartilage development, osteoarthritis (OA) pathophysiology and its therapeutic potential for treating OA we applied the following five strategical analyses using (1 ...
Xiangfen Li, Xiangfen Li, Xiaofang Zhu, Hongle Wu, Hongle Wu, Thomas E. Van Dyke, Thomas E. Van Dyke, Xiaoyang Xu, Elise F. Morgan, Wenyu Fu, Wenyu Fu, Chuanju Liu, Chuanju Liu, Qisheng Tu, Dingming Huang, Jake Chen   +15 more
doaj   +1 more source

Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis

Biomolecules, 2022
Irisin is an adipo-myokine, mainly synthetized in skeletal muscles and adipose tissues, that is involved in multiple processes. Only a few studies have evaluated serum irisin in psoriatic patients.
Francesca Ambrogio, Lorenzo Sanesi, Angela Oranger, Chiara Barlusconi, Manuela Dicarlo, Patrizia Pignataro, Roberta Zerlotin, Paolo Romita, Elvira Favoino, Gerardo Cazzato, Nicoletta Cassano, Gino Antonio Vena, Caterina Foti, Maria Grano   +13 more
doaj   +1 more source

Relationship of serum irisin levels and various demographic and biochemical factors in non-diabetic hemodialysis patients [PDF]

Journal of Preventive Epidemiology, 2020
Introduction: Irisin is a myokine secreted from the skeletal muscle. Preliminary studies showed that the serum irisin level was decreased in patients with chronic kidney disease (CKD), particularly in hemodialysis patients.
Fereshteh Rafi’i, Seyed Mohsen Hosaini, Banafsheh Yalameha, Hamid Nasri   +3 more
doaj   +1 more source

Inverse correlation between serum irisin and cardiovascular risk factors among Chinese overweight/obese population

BMC Cardiovascular Disorders, 2021
Background Irisin is a novel myokine associated with obesity, which is a traditional cardiovascular risk factor (CVRF). The present study aimed to investigate the association between serum irisin and a single CVRF as well as the clustering of CVRFs among
Ruoyi Liu, Qiao Zhang, Nianchun Peng, Shujing Xu, Miao Zhang, Ying Hu, Zhengyi Chen, Kun Tang, Xi He, Yi Li, Lixin Shi   +10 more
doaj   +1 more source

The effects of 8-week resistance and endurance trainings on bone strength compared to irisin injection protocol in mice

Advanced Biomedical Research, 2021
Background: Osteoporosis is a prevalent elderly complication that is characterized by decreased bone mineral density and increased fracture risk because of dysregulation in bone mineralization and resorption.
Shirin Shahabi, Fahimeh Esfarjani, Jalil Reisi, Sedigheh Momenzadeh, Mohammad-Saeid Jami, Saeed Zamani   +5 more
doaj   +1 more source