Results 11 to 20 of about 7,364 (142)

Serum irisin levels increase in girls with central precocious puberty not dependent on BMI: a pilot study

open access: yesEndocrine Connections, 2022
Objective: The objective of this study is to investigate the role of seru m irisin level in diagnosis of central precocious puberty (CPP) in girls and its major determinants.
Yanfei Chen   +4 more
doaj   +1 more source

Irisin regulates cardiac physiology in zebrafish.

open access: yesPLoS ONE, 2017
Irisin is a myokine encoded in its precursor fibronectin type III domain containing 5 (FNDC5). It is abundantly expressed in cardiac and skeletal muscle, and is secreted upon the activation of peroxisome proliferator-activated receptor gamma coactivator ...
Lakshminarasimhan Sundarrajan   +4 more
doaj   +1 more source

Expression and Function of Synthetic Dimeric Exercise-Induced Cytokine Irisin-Irisin

open access: yes康复学报, 2023
ObjectiveStudies have shown that the exercise-induced cytokine Irisin functions were as a dimer, so tandem Irisin-Irisin mock dimers were designed to explore the similarities and differences between recombinant Irisin-Irisin expressed by Escherichia coli
LIU Fengying   +5 more
doaj  

Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts. [PDF]

open access: yesPLoS ONE, 2015
Exercise offers short-term and long-term health benefits, including an increased metabolic rate and energy expenditure in myocardium. The newly-discovered exercise-induced myokine, irisin, stimulates conversion of white into brown adipocytes as well as ...
Chao Xie   +14 more
doaj   +1 more source

Irisin Exerts Inhibitory Effect on Adipogenesis Through Regulation of Wnt Signaling

open access: yesFrontiers in Physiology, 2019
Irisin is an exercise-induced myokine known to induce adipocyte browning through induction of uncoupling protein 1. Recent studies have reported that irisin is also an adipokine.
Eun Bi Ma   +3 more
doaj   +1 more source

Irisin: Still chasing shadows

open access: yesMolecular Metabolism, 2020
Objective: Considerable uncertainty remains regarding the veracity of measuring myokine irisin more than seven years after its original description. Unresolved issues include the nature of transcription of the irisin precursor fibronectin type III domain
Elke Albrecht   +6 more
doaj   +1 more source

Exploring the role of esketamine in alleviating depressive symptoms in mice via the PGC-1α/irisin/ERK1/2 signaling pathway

open access: yesScientific Reports, 2023
Esketamine provides an immediate and noticeable antidepressant effect, although the underlying molecular processes are yet unclear. Irisin induced by aerobic exercise has been implicated in the alleviation of depressive symptoms, whether irisin ...
Na Hu   +9 more
doaj   +1 more source

Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis

open access: yesFrontiers in Pharmacology, 2019
ObjectiveThe aim of this study was to investigate whether the nuclear receptor farnesoid X receptor (FXR) could regulate FNDC5/Irisin expression and the role of Irisin in hyperlipidemia and atherosclerosis in ApoE-/- mice.Methods and ResultsWe treated ...
Hong Li   +24 more
doaj   +1 more source

Dose-dependent tandem responses of osteoblasts during osteogenesis

open access: yesMedicine in Novel Technology and Devices, 2023
Irisin, a myokine mainly secreted from contracted skeleton muscle, plays a profound role in bone formation and remodeling. Although irisin has been revealed to elevate bone mass in vivo, details whether there is a dose-dependent relationship between ...
Yuwei Zhang   +4 more
doaj   +1 more source

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