Results 11 to 20 of about 18,190 (273)
Molecular Metabolism, 2020 Objective: Considerable uncertainty remains regarding the veracity of measuring myokine irisin more than seven years after its original description. Unresolved issues include the nature of transcription of the irisin precursor fibronectin type III domain
Elke Albrecht +6 more
doaj +5 more sources
Expression and Function of Synthetic Dimeric Exercise-Induced Cytokine Irisin-Irisin
康复学报, 2023 ObjectiveStudies have shown that the exercise-induced cytokine Irisin functions were as a dimer, so tandem Irisin-Irisin mock dimers were designed to explore the similarities and differences between recombinant Irisin-Irisin expressed by Escherichia coli
LIU Fengying +5 more
doaj +2 more sources
Irisin and Autophagy: First Update [PDF]
International Journal of Molecular Sciences, 2020 Aging and sedentary life style are considered independent risk factors for many disorders. Under these conditions, accumulation of dysfunctional and damaged cellular proteins and organelles occurs, resulting in a cellular degeneration and cell death. Autophagy is a conserved recycling pathway responsible for the degradation, then turnover of cellular ...
Mirko Pesce +5 more
openalex +4 more sources
Irisin in Liver Cirrhosis [PDF]
Journal of Clinical Medicine, 2020 Background: Sarcopenia is a prevalent muscle abnormality characterized by progressive and generalized loss of skeletal muscle mass and strength, common among patients with decompensated advanced chronic liver disease (dACLD). Irisin is a recently identified myokine, which is mainly expressed and secreted by skeletal muscle.
Michał Kukla +11 more
openaire +3 more sources
International Journal of Endocrinology, 2013 In January 2012, Boström and colleagues identified a new muscle tissue secreted peptide, which they named irisin, to highlight its role as a messenger that comes from skeletal muscle to other parts of the body. Irisin is a cleaved and secreted fragment of FNDC5 (also known as FRCP2 and PeP), a member of fibronectin type III repeat containing gene ...
Marta G. Novelle +4 more
openaire +7 more sources
Irisin—A Pancreatic Islet Hormone [PDF]
Biomedicines, 2022 Irisin is a myokine involved in glucose homeostasis. It is primarily expressed in skeletal muscle, but also in the pancreas. This study aimed to elucidate its presence and role in the islets of Langerhans—i.e., its effect on insulin and glucagon secretion as well as on blood flow in the pancreas.
Daniel Norman +3 more
openaire +5 more sources
The optimal therapeutic irisin dose intervention in animal model: A systematic review [PDF]
Veterinary World, 2020 Background and Aim: Irisin, a novel myocyte-secreted hormone, was proposed to mediate some of the beneficial effects of exercise such as browning of adipocytes, thermogenesis, and metabolic homeostasis.
Foad Alzoughool +5 more
doaj +1 more source
Relationship of serum irisin levels and various demographic and biochemical factors in non-diabetic hemodialysis patients [PDF]
Journal of Preventive Epidemiology, 2020 Introduction: Irisin is a myokine secreted from the skeletal muscle. Preliminary studies showed that the serum irisin level was decreased in patients with chronic kidney disease (CKD), particularly in hemodialysis patients.
Fereshteh Rafi’i +3 more
doaj +1 more source
Irisin: ‘fat’ or artefact [PDF]
Clinical Endocrinology, 2014 SummarySoon after the discovery of the muscle‐derived factor irisin, a great controversy arose in the literature regarding certain inconsistencies in the regulation of the fibronectin type III domain containing 5 protein (FNDC5/irisin) after exercise, as well as the unpredicted association of circulating irisin levels with parameters of adiposity in ...
Crujeiras Martínez, Ana Belén +2 more
openaire +3 more sources
BMC Cardiovascular Disorders, 2021 Background Irisin is a novel myokine associated with obesity, which is a traditional cardiovascular risk factor (CVRF). The present study aimed to investigate the association between serum irisin and a single CVRF as well as the clustering of CVRFs among
Ruoyi Liu +10 more
doaj +1 more source