Results 81 to 90 of about 7,212 (245)

Evolutionary Insights into Irisin/FNDC5: Roles in Aging and Disease from Drosophila to Mammals

Biomolecules
The Irisin/FNDC5 protein family has emerged as a pivotal link between exercise and the prevention of age-associated diseases. Irisin is highly expressed during exercise from skeletal and cardiac muscle cells, playing a critical role in mediating systemic
Kiwon Lee, Myungjin Kim
semanticscholar   +1 more source

FNDC4 and FNDC5 Attenuate SARS‐CoV‐2 S1‐Induced Inflammatory Responses in Human Adipose Tissue

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
In obesity, reduced FNDC4 and FNDC5 amplify SARS‐CoV‐2 S1–driven inflammation in visceral adipose tissue. These adipo‐myokines limit adipocyte–macrophage inflammatory signalling, suggesting a protective role against viral‐induced adipose tissue dysfunction.
Gabriela Neira, Julia Hernández‐Castañeda, Victoria Catalán, Sara Becerril, Marina Martín, Víctor Valentí, Rafael Moncada, Camilo Silva, Javier Gómez‐Ambrosi, Javier Escalada, Gema Frühbeck, Amaia Rodríguez   +11 more
wiley   +1 more source

Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression

eneuro, 2023
AbstractMajor depressive disorder (MDD) is a major cause of disability in adults. MDD is both a comorbidity and a risk factor for Alzheimer’s disease (AD), and regular physical exercise has been associated with reduced incidence and severity of MDD and AD. Irisin is an exercise-induced myokine derived from proteolytic processing of fibronectin type III
Ricardo Lima-Filho, Juliana S. Fortuna, Danielle Cozachenco, Alinny R. Isaac, Natalia Lyra e Silva, Alice Saldanha, Luis E. Santos, Sergio T. Ferreira, Mychael V. Lourenco, Fernanda G. De Felice   +9 more
openaire   +2 more sources

High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion [PDF]

, 2018
Background and aim: Perivascular adipose tissue (PVAT) positively regulates vascular function through production of factors such as adiponectin but this effect is attenuated in obesity.
Alganga, Husam, Almabrouk, Tarek A.M., Guzik, Tomasz J., Katwan, Omar J., Kennedy, Simon, Salt, Ian P., Skiba, Dominik S., Touyz, Rhian M., Ugusman, Azizah B., White, Anna D.   +9 more
core   +2 more sources

The skeletal muscle–adipose creatine metabolic axis: A novel paradigm for lipid metabolism reprogramming and obesity management

Experimental Physiology, Volume 111, Issue 4, Page 1700-1707, 1 April 2026.
Abstract The global prevalence of obesity and related metabolic disorders has spurred interdisciplinary research to develop new intervention strategies. Current research is increasingly focusing on the exercise‐induced browning of white adipose tissue and the mechanisms by which it improves energy metabolism.
Yuhui Su, Na Liu, Yang Liu, Yiqun Sun, Yike Jiao   +4 more
wiley   +1 more source

New insights into the cellular activities of Fndc5/Irisin and its signaling pathways

Cell & Bioscience, 2020
Fndc5, a well-defined myokine and also identified as an adipokine, has a critical role in modulation of metabolism and protection against obesity. These important functions are mediated by irisin, a secretory peptide produced from proteolytic processing ...
Farzaneh Rabiee, Liana Lachinani, Sarvenaz Ghaedi, Mohammad Hossein Nasr-Esfahani, Timothy L. Megraw, Kamran Ghaedi   +5 more
doaj   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, Volume 13, Issue 18, 27 March 2026.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer’s disease

Molecular Brain, 2018
The deposition of Amyloid-beta peptides (Aβ) is detected at an earlier stage in Alzheimer’s disease (AD) pathology. Thus, the approach toward Aβ metabolism is considered to play a critical role in the onset and progression of AD.
Yasuha Noda, Akira Kuzuya, Kyousuke Tanigawa, Mitsugu Araki, Ryoko Kawai, Biao Ma, Yoko Sasakura, Masato Maesako, Yoshitaka Tashiro, Masakazu Miyamoto, Kengo Uemura, Yasushi Okuno, Ayae Kinoshita   +12 more
doaj   +1 more source

The effect of exercise interventions on Irisin level

EXCLI Journal : Experimental and Clinical Sciences, 2022
Irisin is a hormone that is offered to be a hopeful remedial target in obesity and type 2 diabetes. It has received striking attention recently, whereas, the interactions between exercise training and irisin are still unclear.
Gholam Rasul Mohammad Rahimi, Keyvan Hejazi, Martin Hofmeister   +2 more
doaj   +1 more source

Ontogeny and thermogenic role for sternal fat in female sheep [PDF]

, 2017
Brown adipose tissue acting through a unique uncoupling protein (UCP1) has a critical role in preventing hypothermia in new-born sheep but is then considered to rapidly disappear during postnatal life.
Albrecht, Alexander, Alexander, Atit, Bal, Barquissau, Basse, Belinda A. Henry, Bispham, Blessing, Blondin, Bloor, Cantile, Cao, Christian, Christodoulides, Clapham, Clarke, Clarke, Clarke, de Jong, Ellis, Elsen, Forner, Gburcik, Harms, Helen Budge, Henry, Henry, Henry, Henry, Horvath, Hotta, Hunt, Iain J. Clarke, John-Paul Fuller-Jackson, Kiskinis, Kooijman, Kurose, Lean, Lee, Lee, Loomis, Macotela, Mark Birtwistle, Mark Pope, Michael E. Symonds, Moldes, Møller, Nedergaard, Nedergaard, Nygaard, Ojha, Ootsuka, Petrovic, Pope, Rachael Loughnan, Ramayo-Caldas, Reham Alagal, Rosell, Rowland, Sacks, Sanchez-Gurmaches, Sanchez-Gurmaches, Scheele, Scotney, Seale, Sechen, Shan, Shinoda, Symonds, Symonds, Symonds, Symonds, Symonds, Symonds, Symonds, Timmons, van Marken Lichtenbelt, Vergnes, Virtanen, Viv Perry, Wellik, Xue, Yamamoto   +84 more
core   +2 more sources