Results 61 to 70 of about 7,212 (245)

Investigating mechanisms underpinning the detrimental impact of a high-fat diet in the developing and adult hypermuscular myostatin null mouse [PDF]

, 2015
Background: Obese adults are prone to develop metabolic and cardiovascular diseases. Furthermore, over-weight expectant mothers give birth to large babies who also have increased likelihood of developing metabolic and cardiovascular diseases. Fundamental
A Matsakas, A Matsakas, A Matsakas, A Matsakas, A Raben, A Roca-Rivada, AC McPherron, AC McPherron, AD Kriketos, AD Kriketos, AJ Wade, B Zhao, BC Song, C Cooper, C Zhang, CE Brown, CL Mendias, CN Hales, DJ Barker, DJ Barker, DS Mosher, ED Rosen, F Backhed, F Zurlo, G Aldini, G Liebisch, GP Holloway, GP Holloway, H Abe, H Amthor, H Lees, J Abou Mrad, J He, JF Tong, JP Thyfault, JR Swann, JT Tansey, K Relizani, KM Chan, KR Westerterp, M Qatanani, M Scherer, M Scherer, M Schuelke, MW Hamrick, O Beckonert, P Bostrom, Q Wang, R Kohen, RE Williams, RM Avena, S Girgenrath, T Guo, T Westergaard, T Westergaard, T Westergaard, TP Ciaraldi, V Matyash, VA Narkar, YX Wang   +59 more
core   +2 more sources

FNDC5 affects invasion and migration of oral cancer by inhibiting PI3K/Akt/Snail signaling pathway

Scientific Reports
This study first investigated how FNDC5 affected the development of oral cancer and revealed the role of FNDC5 in the migration and invasion of oral cancer.
Fang Zhao, Dongyang Xu, Xiumei Wang, Xiaofeng Wang   +3 more
doaj   +1 more source

Effects of Pretreatment With Coenzyme Q10 (CoQ10) and High‐Intensity Interval Training (HIIT) on FNDC5, Irisin, and BDNF Levels, and Amyloid‐Beta (Aβ) Plaque Formation in the Hippocampus of Aβ‐Induced Alzheimer's Disease Rats

CNS Neuroscience & Therapeutics
Physical exercise has been shown to protect against cognitive decline in Alzheimer's disease (AD), likely through the upregulation of brain‐derived neurotrophic factor (BDNF).
Samira Puoyan-Majd, Abdolhossein Parnow, Masome Rashno, R. Heidarimoghadam, Alireza Komaki   +4 more
semanticscholar   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Diagnosing and Treating Periodontitis and Multimorbidity Altogether: The Case Example of the Physical Exercise Hormone Irisin

Journal of Periodontal Research, EarlyView.
Irisin is an extracellular peptide stimulated by exercise and could act as both a biomarker and mediate the positive impact of exercise. This scoping review synthesizes human evidence on irisin variations in non‐communicable diseases, showing an increase of irisin in saliva and gingival tissues in periodontitis, potentially reflecting reparative or ...
Larysa Saboya Cavalotti Perdonsini, Rafael Scaf de Molon, Søren Jepsen, Iain Chapple, Joao Paulo Steffens   +4 more
wiley   +1 more source

Comparative Genomic Characterization of Buffalo Fibronectin Type III Domain Proteins: Exploring the Novel Role of FNDC5/Irisin as a Ligand of Gonadal Receptors

Biology, 2021
FN-III proteins are widely distributed in mammals and are usually involved in cellular growth, differentiation, and adhesion. The FNDC5/irisin regulates energy metabolism and is present in different tissues (liver, brain, etc.).
Siwen Wu, Faiz-ul Hassan, Yuhong Luo, Israr Fatima, Ishtiaq Ahmed, Awais Ihsan, Warda Safdar, Qingyou Liu, Saif ur Rehman   +8 more
doaj   +1 more source

The stormy relationship between fats and the development of type 2 diabetes mellitus: Updated. Part 2 [PDF]

, 2017
En esta parte de la revisión se describe la relación funcional entre el metabolismo de los lípidos y los hidratos de carbono y su interdependencia, desde el ciclo glucosa-ácido grasos y la hipótesis portal de la insulinorresistencia a los nuevos ...
Costa Gil, José Esteban, Spinedi, Eduardo Julio   +1 more
core   +2 more sources

Multidisciplinary Therapy to Target Obesity and Its Complications in Adult Population: A Narrative Review

Obesity Reviews, EarlyView.
ABSTRACT Obesity as a chronic and multifactorial disease requires a multidisciplinary team acting together in a holistic multitarget intervention. Multidisciplinary therapy targeting obesity and its complications includes physical exercise, nutritional, and behavior counseling.
Ana Raimunda Dâmaso, Flávia Campos Corgosinho, Deborah Cristina Landi Masquio, Nayra Figueiredo, Fabiana Kattah, Cintia Cercato, Lian Tock, Raquel Munhoz da Silveira Campos   +7 more
wiley   +1 more source

Association of Irisin/FNDC5 with ERRα and PGC-1α Expression in NSCLC

International Journal of Molecular Sciences, 2022
The rapid growth and division of cancer cells are associated with mitochondrial biogenesis or switching to glycolysis. ERRα, PGC-1α and irisin/FNDC5 are some of the proteins that can influence these processes. The aim of this study was to determine the correlation of these proteins in non-small cell lung cancer (NSCLC) and to investigate their ...
Katarzyna Nowińska, Karolina Jabłońska, Urszula Ciesielska, Aleksandra Piotrowska, Katarzyna Haczkiewicz-Leśniak, Konrad Pawełczyk, Marzenna Podhorska-Okołów, Piotr Dzięgiel   +7 more
openaire   +2 more sources

Fibronectin Type III Domain-Containing 5 Attenuates Liver Fibrosis Via Inhibition of Hepatic Stellate Cell Activation

Cellular Physiology and Biochemistry, 2018
Background/Aims: Fibronectin type III domain-containing 5 (FNDC5) protein is involved in the beneficial effects of exercise on metabolism. FNDC5 attenuates hepatic steatosis induced by high fat diet (HFD).
Bing Zhou, Li Ling, Feng Zhang, Tong-Yan Liu, Hong Zhou, Xiao-Hong Qi, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu   +9 more
doaj   +1 more source