Effects of low-intensity pulsed ultrasound on muscle mass and Fndc5 mRNA expression in aged male mice. [PDF]
BiogerontologySarcopenia, the progressive loss of skeletal muscle mass and function with aging, is a growing public health concern. Conventional treatments such as exercise, pharmacological agents, and nutritional support offer limited efficacy, especially in older ...
Kojima Y.
europepmc +2 more sources
The role of exercise-related FNDC5/irisin in depression
Frontiers in PharmacologyThe complexity of depression presents a significant challenge to traditional treatment methods, such as medication and psychotherapy. Recent studies have shown that exercise can effectively reduce depressive symptoms, offering a new alternative for ...
Yaqi Liu +4 more
semanticscholar +4 more sources
The diagnostic value of FNDC5/Irisin in renal Cell Cancer [PDF]
International Brazilian Journal of Urology, 2018 Purposes: The aim of this study was to determine the diagnostic significance of fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in the sera of patients with renal cell cancer.
Diler Us Altay +5 more
doaj +4 more sources
Investigation of rs1746661 Polymorphism in FNDC5 Gene in Obese Patients [PDF]
Disease and DiagnosisBackground: Obesity is a multifactorial disorder that has considerably increased in developing countries in recent years. This disease results from an imbalance between energy intake and expenditure, influenced by various factors such as behavior, diet ...
Elham Hadi +3 more
doaj +2 more sources
Irisin/FNDC5 Regulates Endothelial Function to Improve Post-Stroke-Induced Cognitive Dysfunction by Stimulating AMPK-eNOS Signaling. [PDF]
Brain BehavCognitive impairment is one of the main complications after a stroke and seriously affects the quality of life and survival time of patients, thereby causing a heavy burden on the social economy and public health.
Guo HH +9 more
europepmc +2 more sources
Effects of Lipid-Lowering Drugs on Irisin in Human Subjects In Vivo and in Human Skeletal Muscle Cells Ex Vivo [PDF]
, 2013 Context and Objective The myokine irisin has been proposed to regulate energy homeostasis. Little is known about its association with metabolic parameters and especially with parameters influencing pathways of lipid metabolism.
Berman, Reena +6 more
core +20 more sources
FNDC5 expression closely correlates with muscle fiber types in porcine longissimus dorsi muscle and regulates myosin heavy chains (MyHCs) mRNA expression in C2C12 cells [PDF]
PeerJ, 2021 Background Irisin (a glycosylated protein) is cleaved from fibronectin type III domain-containing protein 5 (FNDC5), which is expressed mainly in animal muscle tissues and has multiple metabolic regulatory activities.
Xiao-Ming Men +4 more
doaj +2 more sources
Significance of Irisin (FNDC5) Expression in Colorectal Cancer [PDF]
In Vivo, 2021 The role of irisin, the extracellular part of fibronectin type III domain containing 5 (FNDC5), in colorectal cancer (CRC) is unclear. The aim of this study was to investigate immunohistochemical (IHC) expression level of irisin and correlations with clinicopathological factors in patients with CRC.We collected 222 archived CRC samples and 26 control ...
Slawomir, Wozniak +3 more
openaire +3 more sources
Low FNDC5/Irisin expression is associated with aggressive phenotypes in gastric cancer
Frontiers in Pharmacology, 2022 Background: FNDC5 belongs to the family of proteins called fibronectin type III domain-containing which carry out a variety of functions. The expression of FNDC5 is associated with the occurrence and development of tumors.
Luyun Xu +15 more
doaj +1 more source
Irisin/FNDC5: A participant in camel metabolism
Saudi Journal of Biological Sciences, 2021 The quantification, localization, production, function, and regulation of irisin/FNDC5 in camel species have not been previously studied. The objective of this study was to detect the irisin content in Arabian camel blood and tissues and study the gene expression of FNDC5 and PGC-1α in camel skeletal muscles and white adipose tissue depots under basal ...
Kirat, Doaa +3 more
openaire +2 more sources