Results 101 to 110 of about 16,008 (261)

Correction of Ineffective Erythropoiesis and Normalization of Iron Homeostasis After Exagamglogene Autotemcel in Transfusion‐Dependent β‐Thalassemia

American Journal of Hematology, EarlyView.
ABSTRACT Exagamglogene autotemcel (exa‐cel) is a one‐time, ex vivo, CRISPR‐Cas9 gene edited cell therapy approved for patients with transfusion dependent β‐thalassemia (TDT) aged 12–35 years. In a Phase 3 study (CLIMB THAL‐111), exa‐cel treatment resulted in reactivation of fetal hemoglobin and increases in total hemoglobin, leading to transfusion ...
Sujit Sheth, Selim Corbacioglu, Josu de la Fuente, Mattia Algeri, Joachim Rupprecht, Kevin H. M. Kuo, Ami J. Shah, Peter Lang, Hayley Merkeley, Ben Carpenter, Markus Y. Mapara, Robert I. Liem, Stephan Grupp, Yogi Chopra, Amanda M. Li, Janet L. Kwiatkowski, Melanie Kirby‐Allen, Maria Domenica Cappellini, Antonis Kattamis, Sakellarios Zairis, Tina Liu, William Hobbs, Haydar Frangoul, Franco Locatelli, Roland Meisel, on behalf of the CLIMB THAL‐111 and CLIMB‐131 Study Groups   +25 more
wiley   +1 more source

[Dietary supplement of iron for iron deficiency].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2013
A low supply of iron in the diet may result in iron deficiency and mild iron-deficiency anaemia in healthy individuals. Women are more susceptible than men because of menstrual iron loss. We compared the effect of a low dose of iron, administered as a dietary supplement, with a high pharmacological dose of iron to otherwise healthy individuals with ...
Rune J, Ulvik, Rolf, Møller, Tor, Hervig   +2 more
openaire   +1 more source

Optimal management of iron deficiency anemia due to poor dietary intake

, 2011
Kattalin Aspuru1, Carlos Villa2, Fernando Bermejo2, Pilar Herrero3, Santiago García López1 1Digestive Department, Hospital Universitario Miguel Servet (Miguel Servet University Hospital), Zaragoza, 2Digestive Department ...
Bermejo F, Villa C, Aspuru K, García-López S, Herrero P   +4 more
core  

Response surface analysis of rat bone composition changes by dietary calcium and silicon [PDF]

, 2003
Plan BSilicon (Si) apparently is involved in bone calcification; however, its affect appears to be related to dietary calcium. The objective of this experiment was to determine the effects of varying concentrations of dietary silicon on bone ...
McCrady, Shelly
core  

A freshwater diet-derived 14C reservoir effect at the Stone Age sites in the Iron Gates gorge [PDF]

, 2001
Human bones from single inhumation burials and artifacts made from terrestrial mammal (ungulate) bone found in direct association with the skeletons were obtained from the Stone Age site of Schela Cladovei situated just below the Iron Gates Gorge of the ...
McSweeney, Kathleen, Hedges, Robert, Pettitt, Paul B., Bonsall, C., Boroneanț, Vasile, Cook, Gordon, Pettitt, Paul, Bonsall, Clive, Hedges, Robert E. M., Cook, Gordon T., McSweeney, K., Boronean, V.   +11 more
core   +1 more source

The Effect of Iron on Cognitive Development and Function in Infants, Children and Adolescents: A Systematic Review [PDF]

, 2011
A systematic review was conducted to summarize the evidence currently available from randomized controlled trials (RCTs) concerning the effect of iron intake of infants, children and adolescents on measures of cognitive development and function.
Vesna Vucic, Roman-Vinas, Blanca, Iris Iglesia-Altaba, Iglesia-Altaba, Iris, Berthold Koletzko, Christiane Vollhardt, Hermoso, M., Hermoso, Maria, Arsic, A., Vucic, Vesna, Roman-Viñas, B., Gurinovic, M., Aleksandra Arsic, Gurinovic, Mirjana, Mirjana Gurinovic, Vollhardt, C., Vucic, V., Arsic, Aleksandra, Blanca Roman-Viñas, Vollhardt, Christiane, Iglesia-Altaba, I., Koletzko, Berthold, Vučić, Vesna M., Maria Hermoso, Koletzko, B.   +24 more
core   +1 more source

Therapeutic Silencing of Tmprss6 Reduces Iron‐Induced Inflammation and Prolongs Survival in MDS Mice

American Journal of Hematology, EarlyView.
ABSTRACT Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and an increased risk of progression to acute myeloid leukemia (AML). Despite advances in supportive and targeted therapies, disease‐modifying interventions remain limited.
Shahla Vilcassim, Nuttanan Pholngam, Rattanawan Thubthed, Tiwaporn Nualkaew, Saovaros Svasti, Pornthip Chaichompoo, Kai Kysenius, Peter J. Crouch, Sibylle Dames, Mona Eisermann, Alberto Martinez, Ute Schaeper, Jim Vadolas, George Grigoriadis   +13 more
wiley   +1 more source

High-iron consumption decreases copper accumulation and colon length, and alters serum lipids

Applied Biological Chemistry
In this study, we aimed to demonstrate that a significant increase in dietary iron intake disrupts the regulation of copper availability, ultimately leading to systemic copper deficiency.
Jisu Lee, Hyun-Joo Lee, Hyunsoo Jang, Jae-Joon Lee, Jung-Heun Ha   +4 more
doaj   +1 more source

Cadmium in the mammary gland and neonatal intestine [PDF]

, 2010
Cadmium is a ubiquitous toxic metal known to cause several adverse health effects in humans. Newborns have an increased gastrointestinal absorption of cadmium compared to adults and seem to be more sensitive to cadmium toxicity.
Öhrvik, Helena
core  

Dietary intake and nutritional adequacy prior to conception and during pregnancy: a follow-up study in the north of Portugal. [PDF]

, 2008
OBJECTIVE: To assess maternal diet and nutritional adequacy prior to conception and during pregnancy. DESIGN: Follow-up of a cohort of pregnant women with collection of questionnaire data throughout pregnancy and after delivery.
Barros, Henrique, Pinto, Elisabete, dos Santos Silva, Isabel   +2 more
core   +1 more source