Results 41 to 50 of about 54,320 (150)

The Iron Maiden. Cytosolic Aconitase/IRP1 Conformational Transition in the Regulation of Ferritin Translation and Iron Hemostasis

Biomolecules, 2021
Maintaining iron homeostasis is fundamental for almost all living beings, and its deregulation correlates with severe and debilitating pathologies.
Cécilia Hognon, Emmanuelle Bignon, Guillaume Harle, Nadège Touche, Stéphanie Grandemange, Antonio Monari   +5 more
doaj   +1 more source

The diversity and applications of microbial iron metabolism and iron-containing proteins

Communications Biology
This collection reflects research that will advance the understanding of hemoproteins, iron-sulfur cluster proteins and other iron-containing proteins, proteins involved in homeostasis of iron/heme and their regulation, or ecological impacts of iron/heme
Haichun Gao, Ingrid Span
doaj   +1 more source

Nitric oxide prevents Aft1 activation and metabolic remodeling in frataxin-deficient yeast

Redox Biology, 2018
Yeast frataxin homolog (Yfh1) is the orthologue of human frataxin, a mitochondrial protein whose deficiency causes Friedreich Ataxia. Yfh1 deficiency activates Aft1, a transcription factor governing iron homeostasis in yeast cells.
David Alsina, Joaquim Ros, Jordi Tamarit
doaj   +1 more source

AI-driven pan-proteome analyses reveal insights into the biohydrometallurgical properties of Acidithiobacillia

Frontiers in Microbiology, 2023
Microorganism-mediated biohydrometallurgy, a sustainable approach for metal recovery from ores, relies on the metabolic activity of acidophilic bacteria.
Liangzhi Li, Liangzhi Li, Lei Zhou, Chengying Jiang, Chengying Jiang, Zhenghua Liu, Zhenghua Liu, Delong Meng, Delong Meng, Feng Luo, Qiang He, Huaqun Yin, Huaqun Yin   +12 more
doaj   +1 more source

Iron–sulfur-protein biogenesis in eukaryotes

Trends in Biochemical Sciences, 2005
Iron-sulfur (Fe-S) clusters (ISCs) are versatile, ancient co-factors of proteins that are involved in electron transport, enzyme catalysis and regulation of gene expression. The synthesis of ISCs and their insertion into apoproteins involves the function of complex cellular machineries.
Lill, Roland, Mühlenhoff, Ulrich
openaire   +2 more sources

NMR as a Tool to Investigate the Processes of Mitochondrial and Cytosolic Iron-Sulfur Cluster Biosynthesis

Molecules, 2018
Iron-sulfur (Fe-S) clusters, the ubiquitous protein cofactors found in all kingdoms of life, perform a myriad of functions including nitrogen fixation, ribosome assembly, DNA repair, mitochondrial respiration, and metabolite catabolism. The biogenesis of
Kai Cai, John L. Markley
doaj   +1 more source

Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions. [PDF]

PLoS Biology, 2010
The cysteine desulfurase IscS is a highly conserved master enzyme initiating sulfur transfer via persulfide to a range of acceptor proteins involved in Fe-S cluster assembly, tRNA modifications, and sulfur-containing cofactor biosynthesis.
Rong Shi, Ariane Proteau, Magda Villarroya, Ismaïl Moukadiri, Linhua Zhang, Jean-François Trempe, Allan Matte, M Eugenia Armengod, Miroslaw Cygler   +8 more
doaj   +1 more source

Constraint-based modeling of yeast mitochondria reveals the dynamics of protein import and iron-sulfur cluster biogenesis

iScience, 2021
Summary: Mitochondria are a hallmark of eukaryal cells and play an important role in cellular metabolism. There is a vast amount of knowledge available on mitochondrial metabolism and essential mitochondrial functions, such as protein import and iron ...
Carl Malina, Francesca Di Bartolomeo, Eduard J. Kerkhoven, Jens Nielsen   +3 more
doaj   +1 more source

Sulfur starvation induces an Fe-replete response and attenuates virulence pathways in Pseudomonas aeruginosa PAO1

BMC Microbiology
Background Understanding bacterial responses to nutrient limitation is critical for developing targeted antimicrobial strategies. Sulfur starvation uniquely induces not only genes responsible for sulfur scavenging but also prominent antioxidant defenses.
Chidozie G. Ugochukwu, Tonia S. Schwartz, Tonya N. Zeczycki, Douglas C. Goodwin, Holly R. Ellis   +4 more
doaj   +1 more source

Maintenance of genome integrity by the late-acting cytoplasmic iron-sulfur assembly (CIA) complex

Frontiers in Genetics, 2023
Iron-sulfur (Fe-S) clusters are unique, redox-active co-factors ubiquitous throughout cellular metabolism. Fe-S cluster synthesis, trafficking, and coordination result from highly coordinated, evolutionarily conserved biosynthetic processes.
M. S. Petronek, B. G. Allen
doaj   +1 more source