Results 41 to 50 of about 277,097 (267)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Maximum Efficiency per Torque Control of Permanent-Magnet Synchronous Machines
Applied Sciences, 2016 High-efficiency permanent-magnet synchronous machine (PMSM) drive systems need not only optimally designed motors but also efficiency-oriented control strategies. However, the existing control strategies only focus on partial loss optimization.
Qingbo Guo +4 more
doaj +1 more source
The Estimation Method Comparison of Iron Loss Coefficients through the Iron Loss Calculation
Journal of Electrical Engineering and Technology, 2013 A new calculation method for iron loss coefficients is proposed by using the Steinmetz equation from Epstein data. The hysteresis loss must have linear characteristic according to the frequency. However, the existing iron loss coefficients are defined by formula of frequency. In this case, the hysteresis loss has non-linear characteristics by frequency.
Yong-Tae Kim, Gyu-Won Cho, Gyu-Tak Kim
openaire +2 more sources
Energy loss spectra of iron [PDF]
Surface and Interface Analysis, 2008 Abstract We present experimental and theoretical studies of the spectra of electrons backscattered from iron. The single surface and bulk excitation ratio in the energy range between 500 and 4000 eV are calculated. The contribution of single inelastically scattered electrons is derived from a dielectric response theory and from the ...
M. Novák +6 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
FEBS Open Bio, EarlyView.KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
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Iron loss evaluation method for SiFe sheet material under PWM inverter excitation
AIP Advances, 2023 This study proposed an iron loss evaluation method for SiFe sheet material under high-frequency current ripple caused by pulse width modulation (PWM) inverter switching.
Hiroaki Matsumori +4 more
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Aging and Cancer, EarlyView.Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath +3 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Neurodegeneration with brain iron accumulation (NBIA) comprises a genetically and clinically heterogeneous group of rare neurological disorders characterized particularly by iron accumulation in the basal ganglia. To date, 15 genes have been associated with NBIA.
Seda Susgun +95 more
wiley +1 more source