Results 61 to 70 of about 46,664 (267)

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source

Do drugs approved via expedited approval pathways have therapeutic advantages? A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Regulators use expedited approval pathways to speed market approval and patient access to promising new drugs. However, there is uncertainty about whether these pathways are successful in approving drugs with significant therapeutic advantages. This systematic review aims to examine the safety, effectiveness and cost‐effectiveness of drugs approved via
Ashleigh Hooimeyer, Eliza J. McEwin, Zhicheng Wang, Joel Lexchin, Barbara Mintzes   +4 more
wiley   +1 more source

Predictors of authorised, unauthorised and persistent absence among secondary school pupils in Scotland

British Educational Research Journal, EarlyView.
Abstract This article examines the factors associated with persistent absenteeism (an absence rate of 10% or higher) and authorised and unauthorised absence among secondary school pupils in Scotland. Using linked administrative data, the analysis focuses on secondary school stages S1–S6 in three academic years.
Silvia Behrens, Morag Treanor, Patricio Troncoso, Bethany Lee‐Shield, Emma Russell, Lee Williamson, Cecilia Macintyre   +6 more
wiley   +1 more source

Breaking point: Identifying the factors that predict suspension from school

British Educational Research Journal, EarlyView.
Abstract School suspensions are associated with adverse educational and psychosocial outcomes, yet little is known about how structural disadvantage, relational factors, health behaviours, well‐being indicators and school‐level factors jointly predict suspension risk in England.
Stephanie Cahill, Roberto Vagnetti, Christopher Knowles, Emma Thornton, Qiqi Cheng, Neil Humphrey   +5 more
wiley   +1 more source

Used building materials as secondary resources – Identification of valuable building material and automized deconstruction

Journal of Facade Design and Engineering, 2017
These days, we are constantly expecting more from the performance of the building envelope with regard to both comfort and ecological compatibility. Operational energy has been undergoing significant improvement, which in turn draws attention to the ...
Magdalena Zabek, Linda Hildebrand, Sigrid Brell-Cokcan, Matti Wirth   +3 more
doaj   +1 more source

Formalising Sustainability Management as a Core Process Group in Project Management

Business Strategy and the Environment, EarlyView.
ABSTRACT Sustainability has become a strategic imperative for organisations, yet widely used project management standards such as the PMBoK sixth and seventh editions still do not formalise how sustainability should be embedded across project work. This gap matters because PMBoK‐based processes shape governance, roles, documentation and performance ...
Cinzia Dessi, Vincenzo Basile, Federica Caboni, Flavio De Trane   +3 more
wiley   +1 more source

Issue Construals and Corporate Water Stewardship

Business Strategy and the Environment, EarlyView.
ABSTRACT In the face of mounting environmental and social pressures, the importance of responsible corporate water stewardship (CWS) should be evident, yet not all businesses are taking water management issues seriously. The aim of this study is to explore why differences in CWS persist, especially within industries facing similar resource challenges ...
Daina Mazutis, Mohamed Chelli, Sharon OSullivan, Katherine Hanly   +3 more
wiley   +1 more source

Economic Efficiency and Payback of Renewable Energy Projects

Proceedings of the International Conference on Applied Innovations in IT
This paper investigates the economic efficiency and payback performance of renewable energy investment projects, with a focus on solar and wind power plants.
Elyor Saitov, Ortikjon Mamasaliev, Madina Mirzakhmudova, Urazbay Erniyozov, Nurzhamal Aldasheva, Xinlei Chen, Ainura Khamzaeva, Dilfuza Umarova, Gulnara Mamedova   +8 more
doaj   +1 more source

Pluripotency of Wolbachia against Arboviruses: the case of yellow fever [version 2; peer review: 2 approved]

Gates Open Research, 2019
Background: Yellow fever outbreaks have re-emerged in Brazil during 2016-18, with mortality rates up to 30%. Although urban transmission has not been reported since 1942, the risk of re-urbanization of yellow fever is significant, as Aedes aegypti is ...
Marcele Neves Rocha, Myrian Morato Duarte, Simone Brutman Mansur, Bianca Daoud Mafra e Silva, Thiago Nunes Pereira, Talita Émile Ribeiro Adelino, Marta Giovanetti, Luis Carlos Junior Alcantara, Franciele Martins Santos, Victor Rodrigues de Melo Costa, Mauro Martins Teixeira, Felipe Campos de Melo Iani, Vivian Vasconcelos Costa, Luciano Andrade Moreira   +13 more
doaj   +1 more source