Results 71 to 80 of about 821,558 (293)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
An Analysis of the U.S. Department of Agriculture's Proposal to Allow Irradiation of Meat [PDF]
Foodborne pathogens in the United States kill thousands and sicken millions each year, despite major efforts by federal agencies and industry to combat the problem.
Lutter, Randall
core
Irradiation Processing Department Monthly Report: 1960-12
, 1961 This document details activities of the Irradiation Processing Department during the month of December ...
Hanford Atomic Products Operation. Irradiation Processing Department.
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Irradiation Processing Department Monthly Report: 1961-08
, 1961 This report details activities of the Irradiation Processing Department during the month of August ...
Hanford Atomic Products Operation. Irradiation Processing Department.
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Estimating the demand for risk reduction from foodborne pathogens through food irradiation [PDF]
In this study the response of US consumers to irradiation in meat processing is examined. Despite scientific evidence of the effectiveness and safety of irradiation, meat processors and retailers have been slow to market irradiated beef products due to ...
Fox, John A., Hartl, Jochen
core
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
H.T.G.C. fuel and moderator material irradiation programme.
, 1958 Probable mechanisms of irradiation damage in fuel and moderating materials of interest to the H.T.G.C. Reactor programme are discussed. A programme is outlined for investigations into irradiation damage in H.T.G.C. fuels and moderators.
Hickman, BS
core
Irradiation Processing Department Monthly Report: 1963-04
, 1963 This document details activities of the Irradiation Processing Department during the month of August, 1958. A general summary is included at the start of the report, after which the report is divided into the following sections: Research and Engineering ...
Hanford Atomic Products Operation. Irradiation Processing Department.
core +1 more source