Results 41 to 50 of about 1,249,952 (349)

Cognitive Functioning in Vorinostat‐Treated Pediatric and Young Adult Patients Over the First 180 Days After Hematopoietic Stem Cell Transplant

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Cognitive and psychological difficulties could negatively interfere with treatment adherence and quality of life before and after hematopoietic stem cell transplant (HSCT). Methods to mitigate these changes may have positive effects on treatment success.
Kristen L. Votruba, Michelle Rozwadowski, Thomas Braun, April Rahrig, Edward Peres, Kirsten M. Williams, Vanessa Fabrizio, Julie‐An Talano, Carrie L. Kitko, Nicolas Parnell, Pavan Reddy, Sung Won Choi   +11 more
wiley   +1 more source

Simulation of the irradiation effect on hardness of Chinese HTGR A508-3 steels with CPFEM

Nuclear Engineering and Technology, 2019
Understanding the irradiation hardening effect of structural steels under various irradiation conditions plays an important role in developing advanced nuclear systems. Such being the case, a crystal plasticity model for body-centered cubic (BCC) crystal
Junfeng Nie, Pandong Lin, Yunpeng Liu, Haiquan Zhang, Xin Wang   +4 more
doaj   +1 more source

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source

Clarifying the effect of irradiation and thermal treatment on the austenitic microstructure and austenitic hardening in austenitic stainless steel weld metal

Journal of Materials Research and Technology
The weld cladding on the inner surface of nuclear pressure vessels due to irradiation damage and thermal effect presents to a safety issue. Unfortunately, the effect of irradiation and long-term thermal treatment on the austenitic microstructure and ...
Xiaodong Gao, Xiaodong Lin, Lining Xu, Yaolei Han, Qunjia Peng, Lijie Qiao   +5 more
doaj   +1 more source

Irradiation hardening induced by blistering in tungsten due to low-energy high flux hydrogen plasma exposure

Journal of Nuclear Materials, 2019
In this work, the microstructure evolution in the near-surface of tungsten under hydrogen (H) plasma exposure conditions was observed by means of scanning electron microscopy (SEM), plasma focused ion beam (FIB) and transmission electron microscopy (TEM)
W.Q. Chen, Xuesu Xiao, B. Pang, S. Si, Y. Jia, B. Xu, T. Morgan, W. Liu, Y. Chiu   +8 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Irradiation hardening and deuterium retention behaviour of tungsten under synergistic irradiations of 3.5 MeV Fe13+ ions and deuterium plasma

Nuclear Materials and Energy, 2023
This work investigates the irradiation hardening and deuterium (D) retention behaviour of tungsten (W) under synergistic irradiations of heavy ions and D plasma.
Ting Wang, Xiaolei Ma, Jipeng Zhu, Shiwei Wang, Yue Yuan, Long Cheng, Peng Zhang, Yuan Gao, Xing-Zhong Cao, Guang-Hong Lu   +9 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Orientation-dependent indentation response of helium-implanted tungsten

, 2019
A literature review of studies investigating the topography of nano-indents in ion-implanted materials reveals seemingly inconsistent observations, with report of both pile-up and sink-in.
Das, Suchandrima, Hofmann, Felix, Tarleton, Edmund, Yu, Hongbing   +3 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source