Results 41 to 50 of about 467,366 (245)

The investigation of the carbon on irradiation hardening and defect clustering in RPV model alloy using ion irradiation and OKMC simulation

Nuclear Engineering and Technology
The precipitation of solutes is a major cause of irradiation hardening and embrittlement limiting the service life of reactor pressure vessel (RPV) steels. Impurities play a significant role in the formation of precipitation in RPV materials.
Yitao Yang, Jianyang Li, Chonghong Zhang
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Evaluation of Irradiation Hardening of P92 Steel under Ar Ion Irradiation

, 2018
P92 steel was irradiated with Ar ion up to 10 dpa at 200, 400, and 700 °C. The effect of Ar ion irradiation on hardness was investigated with nanoindentation tests and microstructure analyses.
Qingshan Li, Xi Huang, Jun Zhu, Yinzhong Shen, Zhongxia Shang   +4 more
core   +1 more source

Ion irradiation effects on FeCrAl-ODS ferritic steel

Nuclear Materials and Energy, 2018
The correlation between microstructure and mechanical property of ion irradiated 12Cr-6Al ODS ferritic steel was studied. Ion irradiation experiments were performed using 10.5 MeV Fe ions up to the nominal displacement damage of 20 dpa with the damage ...
K. Kondo, S. Aoki, S. Yamashita, S. Ukai, K. Sakamoto, M. Hirai, A. Kimura   +6 more
doaj   +1 more source

Neutron irradiation hardening and microstructure changes in Fe–Mn binary alloys [PDF]

, 2011
Irradiation hardening and microstructure changes in Fe–Mn binary alloys were investigated after neutron irradiation at 290 °C and up to 0.13 dpa. Significant irradiation hardening comparable to that of Fe–1 at.%Cu alloy was observed in Fe–1 at.%Mn alloy.
Masashi Saito, Akihiko Kimura, Ryuta Kasada, Kimura, Akihiko, Saito, Masashi, Kiyohiro Yabuuchi, Yabuuchi, Kiyohiro, Kasada, Ryuta   +7 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

The effect of initial microstructure on the irradiation hardening of the W fiber in Wf/W–Y2O3 composites

Journal of Materials Research and Technology
Tungsten fiber-reinforced tungsten (Wf/W) composites are promising candidates for plasma facing materials for fusion devices. The hardening behaviors of unrecrystallized W fiber (NRX-W fiber) and fully recrystallized W fiber (RX-W fiber) in the Wf/W–Y2O3
C. Chen, J.H. Chen, Y. Chen, J. Wang, Y.F. Zhang, S. Wang, H.Y. Chen, Y.R. Mao, L.M. Luo   +8 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Microstructure Characterization and Hardening Evaluation of Ferrite/Martensitic Steels Induced by He²⁺ Irradiation

Crystals, 2023
Two ferrite/martensitic (F/M) steels with different Si concentrations (0 and 0.4 wt.%) were irradiated by 250 keV He2+ ions with different fluences of 2 × 1016 ions/cm2 and 1 × 1017 ions/cm2.
Guangjie Zhang, Junfeng Yang, Zhuoming Xie, Linchao Zhang, Rui Liu, Meng Sun, Gang Li, Hui Wang, Yi Hu, Xuebang Wu, Qianfeng Fang, Changsong Liu, Xianping Wang   +12 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source