Results 41 to 50 of about 23,999 (306)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Irradiation hardening and deuterium retention behaviour of tungsten under synergistic irradiations of 3.5 MeV Fe13+ ions and deuterium plasma

Nuclear Materials and Energy, 2023
This work investigates the irradiation hardening and deuterium (D) retention behaviour of tungsten (W) under synergistic irradiations of heavy ions and D plasma.
Ting Wang, Xiaolei Ma, Jipeng Zhu, Shiwei Wang, Yue Yuan, Long Cheng, Peng Zhang, Yuan Gao, Xing-Zhong Cao, Guang-Hong Lu   +9 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The investigation of the carbon on irradiation hardening and defect clustering in RPV model alloy using ion irradiation and OKMC simulation

Nuclear Engineering and Technology
The precipitation of solutes is a major cause of irradiation hardening and embrittlement limiting the service life of reactor pressure vessel (RPV) steels. Impurities play a significant role in the formation of precipitation in RPV materials.
Yitao Yang, Jianyang Li, Chonghong Zhang
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Investigation of Irradiation Hardening and Effectiveness of Post-Irradiation Annealing on the Recovery of Tensile Properties of VVER-1000 Realistic Welds Irradiated in the LYRA-10 Experiment

Metals
Assessing the embrittlement and hardening of reactor pressure vessel steels is critical for the extension of the service lifetime of nuclear power plants.
Mathilde Laot, Viviam Marques Pereira, Theo Bakker, Elio d’Agata, Oliver Martin, Murthy Kolluri   +5 more
doaj   +1 more source

Microstructure Characterization and Hardening Evaluation of Ferrite/Martensitic Steels Induced by He²⁺ Irradiation

Crystals, 2023
Two ferrite/martensitic (F/M) steels with different Si concentrations (0 and 0.4 wt.%) were irradiated by 250 keV He2+ ions with different fluences of 2 × 1016 ions/cm2 and 1 × 1017 ions/cm2.
Guangjie Zhang, Junfeng Yang, Zhuoming Xie, Linchao Zhang, Rui Liu, Meng Sun, Gang Li, Hui Wang, Yi Hu, Xuebang Wu, Qianfeng Fang, Changsong Liu, Xianping Wang   +12 more
doaj   +1 more source

Orientation-dependent indentation response of helium-implanted tungsten

, 2019
A literature review of studies investigating the topography of nano-indents in ion-implanted materials reveals seemingly inconsistent observations, with report of both pile-up and sink-in.
Das, Suchandrima, Hofmann, Felix, Tarleton, Edmund, Yu, Hongbing   +3 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source