Results 181 to 190 of about 220,280 (253)

Potential clinical utility of small extracellular vesicles derived from head and neck tumours

open access: yesVIEW, Volume 7, Issue 1, February 2026.
Small extracellular vesicles (EVs) carry selective protein cargoes that reflect tumour cell status, making them valuable for biomarker discovery. This study compared EV proteomes from head and neck cancer (HNC) tumour tissue, saliva and plasma. Over 60% of proteins were shared across all sources, with enrichment in cancer‐related pathways such as ...
Abolfazl Jangholi   +6 more
wiley   +1 more source

Integrated multi‐omics analysis reveals metabolic reprogramming as a key driver of angiotensin II‐induced vascular remodeling

open access: yesVIEW, Volume 7, Issue 1, February 2026.
This study investigates the molecular alterations underlying angiotensin II (Ang II)‐induced vascular remodeling in cardiovascular diseases using a multi‐omics approach. Through data exploration and integrated multi‐omics analysis, our findings reveal that Ang II‐driven vascular injury in vascular smooth muscle cells is mediated by metabolic ...
Yiwei Hu   +8 more
wiley   +1 more source

Quality of life and participation after corneal transplantation and potential predictors: A multicenter prospective cohort study

open access: yesActa Ophthalmologica, Volume 104, Issue 1, Page 52-64, February 2026.
Abstract Purpose To evaluate the long‐term effect of corneal transplantation on health‐ and vision‐related quality of life, visual functioning, and societal participation, and to assess potential predictors. Methods We conducted a multicenter prospective cohort study in 11 Dutch hospitals and eye clinics.
E. B. M. Elsman   +9 more
wiley   +1 more source

Refining Scale Measurement: Reassessing Oral Impacts on Daily Performances Properties With Item Response Theory

open access: yesCommunity Dentistry and Oral Epidemiology, Volume 54, Issue 1, Page 126-132, February 2026.
ABSTRACT Objectives Many oral health‐related quality of life instruments have been developed but few have undergone a comprehensive psychometric assessment. One commonly used measure is the Oral Impact on Daily Performance (OIDP). This study revised the configural and metric properties as well as the performance of items based on Item Response Theory ...
Roger Keller Celeste   +3 more
wiley   +1 more source

Differences in Item Discrimination of the 25‐Question Geriatric Locomotive Function Scale Between Younger and Middle‐Aged Adults and Older Adults: An Analysis Using the Item Response Theory

open access: yesGeriatrics &Gerontology International, Volume 26, Issue 2, February 2026.
ABSTRACT Introduction The 25‐item Geriatric Locomotive Function Scale is widely used to identify locomotive syndrome, a condition characterized by progressive decline in motor function. Although its reliability in older adults has been established, item‐level properties across age groups remain unclear.
Shunsuke Yamashina   +3 more
wiley   +1 more source

Psychometric Evaluation of the Patient‐Experienced Continuity of Care Questionnaire (PECQ) Using Rasch Model

open access: yesHealth Expectations, Volume 29, Issue 1, February 2026.
ABSTRACT Background The Patient‐Experienced Continuity of care Questionnaire (PECQ) was developed to measure continuity of care (CoC) in primary care, but has only been evaluated in accordance with classical test theory, which has some weaknesses compared with modern test theory.
Linda Ljungholm   +4 more
wiley   +1 more source

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