Results 171 to 180 of about 7,251 (220)
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Synthesis of Isatin Derivatives.
ChemInform, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
E. G. Mesropyan +3 more
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The Antibacterial Activity of Isatin Hybrids
Current Topics in Medicinal Chemistry, 2022Abstract:Bacterial infections, which cause a wide range of host immune disorders leading to local and systemic tissue damage, are still one of the main causes of patient morbidity and mortality worldwide. Treatment of bacterial infections is challenging, mainly attributed to the rapidly evolving resistance mechanisms, creating an urgent demand to ...
Bi, Liu, Dan, Jiang, Guowen, Hu
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Chemistry – An Asian Journal, 2020
AbstractA general method for the construction of trifluoromethylated 2‐quinolinones has been established herein by using a trifluoromethylative ring expansion of isatin with trifluorodiazoethane. The strategy provides a platform for the rapid synthesis of a wide range of substituted 3‐hydroxy‐4‐trifluoromethyl‐2‐quinolinones.
Muhammad Fahad Jamali +4 more
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AbstractA general method for the construction of trifluoromethylated 2‐quinolinones has been established herein by using a trifluoromethylative ring expansion of isatin with trifluorodiazoethane. The strategy provides a platform for the rapid synthesis of a wide range of substituted 3‐hydroxy‐4‐trifluoromethyl‐2‐quinolinones.
Muhammad Fahad Jamali +4 more
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Journal of Photochemistry, 1987
Abstract Isatin does not show fluorescence or phosphorescence under any conditions. After excitation it undergoes rapid intersystem crossing to the triplet state (τ = 340 ns in deaerated benzene). This triplet state is capable of hydrogen abstraction, yielding a product analogous to pinacol, isatide.
G. Haucke, B. Seidel, A. Graness
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Abstract Isatin does not show fluorescence or phosphorescence under any conditions. After excitation it undergoes rapid intersystem crossing to the triplet state (τ = 340 ns in deaerated benzene). This triplet state is capable of hydrogen abstraction, yielding a product analogous to pinacol, isatide.
G. Haucke, B. Seidel, A. Graness
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Isatin Hybrids and Their Pharmacological Investigations
Mini-Reviews in Medicinal Chemistry, 2021Hybridization is an important strategy to design molecules that can be effectively used to treat fatal diseases known to mankind. Molecular hybrids and their pharmacological investigations aided in discovering several potent isatin (Indole 2, 3 dione) derivatives with anti-HIV, antimalarial, antitubercular, antibacterial, and anticancer activities ...
Bhushan D. Varpe +4 more
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Isatin‐1,2,3‐triazole‐isatin Scaffolds and Their Antibacterial Activity
Journal of Heterocyclic Chemistry, 2019Twelve novel isatin‐1,2,3‐triazole‐isatin scaffolds 5a–l were designed, synthesized, and assessed for their in vitro antibacterial activity in this paper. The preliminary results showed that all dimers only endowed with weak antibacterial activity, which was less active than the reference ciprofloxacin.
Ruijing Cheng, Xinjia Yan, Zhi Xu
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Isatin: A Scaffold with Immense Biodiversity
Mini-Reviews in Medicinal Chemistry, 2021Isatin is an endogenous and a significant category of fused heterocyclic components and has widely been a part of several potential biologically useful synthetics. Since its discovery, tons of research work has been conducted with respect to the synthesis, chemical properties, and biological and industrial applications.
Priyobrata Nath +5 more
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Isatin dimers and their biological activities
Archiv der Pharmazie, 2020AbstractDimerization is a promising strategy to develop novel drug candidates that could extend the biological spectrum, enhance the activity, overcome drug resistance, as well as improve pharmacological, pharmacokinetic, and physicochemical profiles.
Ya‐Zhou Zhang +4 more
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Reaction of Isatin with Thiocarbohydrazide: A Correction
Archiv der Pharmazie, 1991AbstractHeterocycles containing the indole ring system include some novel pharmacologically active compounds1–3). Isatin and its N‐acetylisatin are extremely versatile intermediates in the construction of a variety of heterocyclic systems when reacted with thiosemicarbazide derivatives.
M A, Badawy, S A, Abdel-Hady
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Reaction of ω-Vinyloxyalkylamines with Isatin
Russian Journal of Organic Chemistry, 20033-(ω-Vinyloxyalkylimino)-2,3-dihydroindol-2-ones and 3-(vinyloxyphenylimino)-2,3-dihydroindol-2-ones were synthesized in 34-93% yield by reactions of ω-aminoalkyl and aminophenyl vinyl ethers with isatin.
B. F. Kukharev +3 more
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