Results 221 to 230 of about 258,774 (251)

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Monitoring treatment of delayed cerebral ischaemia in unconscious patients after aneurysmal subarachnoid haemorrhage: a prospective multimodal neuromonitoring study. [PDF]

Stroke Vasc Neurol
Veldeman M, Bögli SY, Olakorede I, Kastenholz N, Weiss M, Conzen-Dilger C, Seyfried KS, Beqiri E, Weyland CS, Clusmann H, Schubert GA, Hoellig A, Smielewski P.   +12 more
europepmc   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Artificial intelligence-guided quantitative coronary CT assessment to rule-in or rule-out myocardial ischaemia. [PDF]

Eur Heart J Cardiovasc Imaging
Kamila PA, Nurmohamed NS, Danad I, Jukema RA, Raijmakers PG, Driessen RS, Bom MJ, van Diemen P, Pontone G, Andreini D, Chang HJ, Katz RJ, Choi AD, Knaapen P, Bax JJ, van Rosendael A, CREDENCE and PACIFIC-1 Investigators.   +16 more
europepmc   +1 more source

Pain management in chronic limb-threatening ischaemia: a multi-centre cross-sectional study. [PDF]

Front Med (Lausanne)
Mi H, Cao K, Yang W, Yao X, Wang W, Luo J, Peng J, Liu Z.   +7 more
europepmc   +1 more source

Prior cardiac events and the interpretation of ECG-based artificial intelligence for inducible myocardial ischaemia. [PDF]

Eur Heart J Digit Health
Munir L, Cai A.
europepmc   +1 more source

Long intramural left coronary artery confined to the left sinus of Valsalva with diastolic deformation: a case report. [PDF]

Eur Heart J Case Rep
Kawabata T, Nabeshima J, Ishii T, Yonetsu T, Fujita T.   +4 more
europepmc   +1 more source

Therapeutic intervention with sinomenine and irisin to preserve cardiac function after ischaemia-reperfusion injury. [PDF]

Exp Physiol
Wu L, Bi S, Belal A, Liu Z.
europepmc   +1 more source

Spatial evidence of senescence-associated pathology after myocardial infarction in humans and therapeutic targeting in ageing mice

Redgrave RE, Zormpas E, Mathison L, Encina MC, Spyridopoulos I, Cockell SJ, Tual-Chalot S, Richardson GD.   +7 more
europepmc   +1 more source

Contemporary Management of Acute Coronary Syndromes in the Cardiac Intensive Care Unit: From Rapid Diagnosis to Early Secondary Prevention. [PDF]

J Cardiovasc Dev Dis
Giamundo DM, Andò G, Mamas MA, Pathak A, Rosa S, Bernardi M, Figliozzi S, Alasnag M, Atar D, Asher E, Sabouret P.   +10 more
europepmc   +1 more source