Results 201 to 210 of about 902,862 (307)

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Effect of percutaneous coronary intervention on chronic total occlusions with documented viability or ischemia: a systematic review and meta-analysis. [PDF]

BMC Cardiovasc Disord
Leite L, Carlos T, Ferraz Costa G, Cruz I, Donato H, Silva R, Castelo-Branco M, Gonçalves L, Ferreira MJ.   +8 more
europepmc   +1 more source

ALDOA‐Mediated Metabolic Reprogramming is a Targetable Vulnerability for Ferroptosis Sensitization in Cancer

Advanced Science, EarlyView.
ALDOA‐depletion‐mediated glycolytic reprogramming promotes autophagy‐mediated degradation of MBOAT2, increasing the ratio of phospholipids containing pro‐ferroptotic polyunsaturated fatty acids over anti‐ferroptotic monounsaturated fatty acids, and thus sensitizing cancer cells to ferroptosis.
Pengqi Wang, Kezhang He, Bowen Wang, Wei Zhou, Ying Zhang, Tianhua Ma, Sheng Ding   +6 more
wiley   +1 more source

Beyond Raynaud's: Atypical Peripheral Vascular Manifestations in a Case of CREST Syndrome. [PDF]

Clin Case Rep
Kumari S, Henna F, Alam U, Khattak F, Kamil KA.   +4 more
europepmc   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Rapid mitochondrial repolarization upon reperfusion after cardiac ischemia. [PDF]

Nat Cardiovasc Res
Giles AV, Covian R, Prag HA, Burger N, Lucotte B, Yu CS, Sun J, Murphy E, Krieg T, Murphy MP, Balaban RS.   +10 more
europepmc   +1 more source

Construction of PANoptosis‐Inhibiting Carbonized Polymer Dots via Machine Learning Potential for Mitigating Chemodrug‐Induced Nephrotoxicity

Advanced Science, EarlyView.
An enhanced sampling method is developed for molecular dynamics based on trained machine learning force fields to guide the construction of PANoptosis‐inhibiting carbonized polymer dots (Lu‐CDs) derived from a flavonoid compound for treating chemodrug‐induced nephrotoxicity.
Xinchen Liu, Jiaxin Zhang, Xiangyu Yan, Nuo Li, Yu‐Chao Dong, Zihao Wang, Daowei Li, Yong Du, Huan Wang   +8 more
wiley   +1 more source

Correction: <i>Lactobacillus</i> amplifies DHAMaR1 conversion to attenuate intestinal ischemia-reperfusion injury via decreasing pyroptosis. [PDF]

Front Immunol
Li T, Cai H, Qiu C, Zhang J, Zhou S, Zhu P, Xian W.   +6 more
europepmc   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source