Results 201 to 210 of about 1,309,370 (384)

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Long non-coding RNA AK023617 orchestrates atherosclerosis by regulating the circadian rhythm of immunity-related GTPase family M protein in macrophages

Non-coding RNA Research
Acute coronary events show a diurnal rhythm, and atherosclerotic plaque vulnerability, as a histomorphological characteristic of major adverse cardiovascular events, is a key target for intervention. Although oscillating microRNAs reduce plaque stability
Rongzhe Lu, Hengxuan Cai, Yige Liu, Guanpeng Ma, Jiaxin Wang, Miao Yan, Zhenming Zhang, Bo Yu, Zhaoying Li, Shaohong Fang   +9 more
doaj  

Therapeutic Effect of an Extract of Spleen in Shock Caused by Liver Ischemia

, 1969
Jacob Fine, Selina Rutenburg, C. Palmerio   +2 more
openalex   +2 more sources

An Electroencephalographic Filter–Processor as an Indicator of Cerebral Ischemia during Carotid Endarterectomy [PDF]

, 1979
Roy F. Cucchiara, Frank W. Sharbrough, Joseph M. Messick, J H Tinrer   +3 more
openalex   +1 more source

USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang, Xueying Wang, Shanhong Lu, Yan Gao, Gangcai Zhu, Guo Li, Zongnan Yu, Junwei Hou, Helei Yan, Wenhui Yuan, Xin Zhang, Mien‐Chie Hung, Zhifeng Liu, Yong Liu   +13 more
wiley   +1 more source

Effect of Coronary Vasodilator Drugs on Retrograde Flow in Areas of Chronic Myocardial Ischemia

, 1964
Wadie M. Fam, Maurice McGregor
openalex   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Exploring the relationship between ankle strength and endurance factors and the severity and level of ischemia in patients with peripheral arterial disease. [PDF]

J Cardiothorac Surg
Hassabi M, Hasani M, Khodabakhshian S, Javanbakht M, Aliakbar S, Movahedi A, Ghorbani H, Mohebbi M, Movahedi H, Nodoushan MHT, Mirani A.   +10 more
europepmc   +1 more source

Thresholds in cerebral ischemia - the ischemic penumbra.

Stroke, 1981
J. Astrup, B. Siesjö, L. Symon
semanticscholar   +1 more source

Chronic Limb Ischemia

JACC: Cardiovascular Interventions, 2017
Ronald P. Caputo, Lawrence A. Garcia
openaire   +3 more sources