Results 101 to 110 of about 107,429 (283)

Case Report: Unusual Neurological Features of Leigh Syndrome due to m.8993T>G Pathogenic Variant in the MT‐ATP6 Gene

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The MT‐ATP6 gene m.8993T>G pathogenic variant has been associated with Leigh syndrome, especially in patients exhibiting a high degree of heteroplasmy. Although patients may present with a wide phenotypic spectrum, characteristic findings include bilateral, symmetric hyperintensities in the basal ganglia and brainstem on brain MRI ...
Ramya Treitel, Julie McLaughlin, Marta Frigeni   +2 more
wiley   +1 more source

B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial:a randomised, double-blind, parallel, placebo-controlled trial [PDF]

, 2010
SummaryBackgroundEpidemiological studies suggest that raised plasma concentrations of total homocysteine might be a risk factor for major vascular events. Whether lowering total homocysteine with B vitamins prevents major vascular events in patients with
Albert, Alberts, Baker, Bamford, Bonaa, Bostom, Casas, Ebbing, Eikelboom, Galan, Hankey, Hassan, House, Jamison, Kasiman, Liem, Liem, Lonn, Mark, Martí-Carvajal, Nuesch, Pocock, Righetti, Schulz, Spence, Spence, Therneau, Toole, Wald, Warlow, Wrone, Zoungas   +31 more
core   +2 more sources

The Expanding Clinical and Genetic Spectrum of Muscle Glycogen Storage Disease 0, (GSD0B)

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glycogen storage disorders are a group of genetic disorders affecting glucose homeostasis in the body. Muscular glycogen stores are essential for liberating glucose for energy supply during bursts of activity and sustained muscle work. Muscle glycogen storage disease 0 (GSD0B) is associated with biallelic variants in GYS1 causing muscular ...
Sarah Donoghue, Smitha Kumble, Pontus Wasling, Lars Alberg, Pia Linton‐Dahlöf, Yilmaz Yildiz, İlker Ertuğrul, Terry Derks, Dwight Koeberl, Emmeline Lagrange, Sabrina Vergnaud, Lidia Pezzani, Maria Iascone, Zornitza Stark, Adam M. Bournazos, Sandra T. Cooper, Gittan Kollberg   +16 more
wiley   +1 more source

Randomized controlled trial of a coordinated care intervention to improve risk factor control after stroke or transient ischemic attack in the safety net: Secondary stroke prevention by Uniting Community and Chronic care model teams Early to End Disparities (SUCCEED). [PDF]

, 2017
BackgroundRecurrent strokes are preventable through awareness and control of risk factors such as hypertension, and through lifestyle changes such as healthier diets, greater physical activity, and smoking cessation. However, vascular risk factor control
Ayala-Rivera, Monica, Barry, Frances, Bryg, Robert, Cheng, Eric M, Corrales, Marilyn, Cunningham, William, Dutta, Tara, Factor, Diane, Ganz, David A, Haber, Hilary, Hill, Valerie, Ibrahim, Nancy, Liu, Honghu, Macias, Mireya, Martinez, Beatrice, McCreath, Heather, Mehta, Bijal, Mittman, Brian, Mojarro-Huang, Elizabeth, Montoya, Ana, Ramirez, Magaly, Rao, Neal, Razmara, Ali, Richards, Adam, Sanossian, Nerses, Sivers-Teixeira, Theresa, Song, Shlee, Towfighi, Amytis, Tran, Jamie, Vickrey, Barbara G, Wacksman, Jeremy, Willis, Phyllis, Wu, Shinyi   +32 more
core   +2 more sources

Impact of different anesthetic protocols during anesthesia for the establishment of a porcine model of acute kidney injury

Animal Models and Experimental Medicine, EarlyView.
This study details the adaptations required to establish a long‐term anesthetic protocol in pigs. Three protocols were evaluated, with some causing malignant hyperthermia, hypoglycemia, or hemoynamic instability. The final protocol proved effective for developing a porcine AKI model requiring adequate arterial pressure maintenance.
Axel Guilpin, Mathieu Magnin, Axel Aigle, Timothée Schuhler, Jean‐Yves Ayoub, Romain Lac, Charlotte Slek, Thomas Brichart, Abdessalem Hammed, Vanessa Louzier   +9 more
wiley   +1 more source

Young Stroke Survivors With No Early Recurrence at High Long‐Term Risk of Adverse Outcomes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Approximately 8% to 21% of strokes affect adults aged 5× that of young controls (hazard ratio, 5.2; 95% CI, 2.8–9.4), compared with a 30% increase at 5 years for older patients (hazard ratio, 1.3; 95% CI, 1.3–1.4).
Jodi D. Edwards, Moira K. Kapral, M. Patrice Lindsay, Jiming Fang, Richard H. Swartz   +4 more
doaj   +1 more source

Research advances in dysphagia animal models

Animal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the establishment, evaluation, and detection of dysphagia animal models in stroke, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) in three kinds of experimental animals (including rodents, nonhuman primates, and other mammals), providing a basis for the selection of appropriate animal models of ...
Junhui Bai, Keling Cheng, Nannan Zhang, Yunfang Chen, Jun Ni, Zhiyong Wang   +5 more
wiley   +1 more source

Detection of Varicella Zoster Virus Reactivation in Cerebrospinal Fluid in Ischemic Stroke or Transient Ischemic Attack

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Epidemiological data suggest that the risk of ischemic stroke increases after varicella‐zoster virus (VZV) reactivation. The frequency of VZV reactivation in acute ischemic stroke (AIS) is unknown.
Wenyang Li, Peter Sguigna, Chintan Rupareliya, Suriya Subramanian, Hisham Salahuddin, Khalil S. Husari, William Moore, Mark Johnson, Alejandro Magadan, Charles Grose, Ank E. Nijhawan, Ty Shang   +11 more
doaj   +1 more source

The FindMNDBiomarker Program: Protein Changes in Motor Neuron Disease/Amyotrophic Lateral Sclerosis Postmortem Tissue and Biofluids

Annals of Neurology, EarlyView.
Objective Biomarkers of disease pathogenesis are critically needed for amyotrophic lateral sclerosis (ALS) to facilitate diagnosis and patient stratification into appropriate therapeutic trials. Proteomic studies offer significant potential to advance this, but reproducibility across laboratories is a key component toward identifying protein changes ...
Gabrielle L. Adler, Matthew C. Kiernan, Rachel H. Tan   +2 more
wiley   +1 more source

Prior Anticoagulation and Short‐ or Long‐Term Clinical Outcomes in Ischemic Stroke or Transient Ischemic Attack Patients With Nonvalvular Atrial Fibrillation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background We aimed to clarify associations between prior anticoagulation and short‐ or long‐term clinical outcomes in ischemic stroke or transient ischemic attack patients with nonvalvular atrial fibrillation.
Keisuke Tokunaga, Masatoshi Koga, Ryo Itabashi, Hiroshi Yamagami, Kenichi Todo, Sohei Yoshimura, Kazumi Kimura, Shoichiro Sato, Tadashi Terasaki, Manabu Inoue, Yoshiaki Shiokawa, Masahito Takagi, Kenji Kamiyama, Kanta Tanaka, Shunya Takizawa, Masayuki Shiozawa, Satoshi Okuda, Yasushi Okada, Tomoaki Kameda, Yoshinari Nagakane, Yasuhiro Hasegawa, Satoshi Shibuya, Yasuhiro Ito, Hideki Matsuoka, Kazuhiro Takamatsu, Kazutoshi Nishiyama, Kazuomi Kario, Yoshiki Yagita, Kyohei Fujita, Daisuke Ando, Masaya Kumamoto, Shoji Arihiro, Kazunori Toyoda   +32 more
doaj   +1 more source